Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kyoko Uehara"'
Autor:
Kazuyuki Tanaka, Hiroki Tanabe, Hiroki Sato, Chisato Ishikawa, Mitsuru Goto, Naoyuki Yanagida, Hiromitsu Akabane, Shiro Yokohama, Kimiharu Hasegawa, Yohei Kitano, Yuya Sugiyama, Kyoko Uehara, Yu Kobayashi, Yuki Murakami, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Keisuke Sato, Sayaka Yuzawa, Mishie Tanino, Masaki Taruiishi, Yasuo Sumi, Yusuke Mizukami, Mikihiro Fujiya, Toshikatsu Okumura
Publikováno v:
Cancer Medicine, Vol 11, Iss 2, Pp 406-416 (2022)
Abstract Background Chemotherapy for advanced gastric cancer is recommended in the guidelines; however, later‐line treatment remains controversial. Since immune checkpoint inhibitors have been used for the treatment of various malignancies, trials
Externí odkaz:
https://doaj.org/article/daf65b9ccb9641848e42f40a39ed3b32
Autor:
Katsuyoshi Ando, Kyoko Uehara, Yuya Sugiyama, Yu Kobayashi, Yuki Murakami, Hiroki Sato, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Toshikatsu Okumura, Mikihiro Fujiya
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
BackgroundThe impact of the body composition on the pathophysiology and clinical course of Crohn's disease (CD) has not been fully elucidated.AimsTo reveal the correlations among body composition and long-term outcomes in CD after anti-TNF therapy.Me
Externí odkaz:
https://doaj.org/article/053985d361224a39bb620d8087213aff
Autor:
Anastasia Hyrina, Christopher Jones, Darlene Chen, Scott Clarkson, Nadire Cochran, Paul Feucht, Gregory Hoffman, Alicia Lindeman, Carsten Russ, Frederic Sigoillot, Tiffany Tsang, Kyoko Uehara, Lili Xie, Don Ganem, Meghan Holdorf
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2970-2978.e6 (2019)
Summary: A hallmark of chronic hepatitis B (CHB) virus infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpoint of any CHB t
Externí odkaz:
https://doaj.org/article/1de14fd71bb445e89c5fdea311bfc65e
Autor:
Xiaolei Ma, Lili Xie, Charles Wartchow, Robert Warne, Yongjin Xu, Alexey Rivkin, David Tully, Steven Shia, Kyoko Uehara, Dianna M. Baldwin, Gladys Muiru, Weidong Zhong, Isabel Zaror, Dirksen E. Bussiere, Vincent H. J. Leonard
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Influenza virus uses a unique mechanism to initiate viral transcription named cap-snatching. The PB2 subunit of the viral heterotrimeric RNA polymerase binds the cap structure of cellular pre-mRNA to promote its cleavage by the PA subunit. T
Externí odkaz:
https://doaj.org/article/0e992cb2a2914995a1aae7e6664172d2
Autor:
Keitaro Takahashi, Yuki Murakami, Takahiro Sasaki, Nobuhiro Ueno, Shion Tachibana, Junpei Ikeda, Kenichi Ishigaki, Masashi Horiuchi, Moe Yoshida, Kyoko Uehara, Yu Kobayashi, Yuya Sugiyama, Takehito Kunogi, Mizue Muto, Katsuyoshi Ando, Momotaro Muto, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Nobuyuki Yanagawa, Kazumichi Harada, Takashi Teramoto, Toshikatsu Okumura, Mikihiro Fujiya
Publikováno v:
Endoscopy. 55:207-216
Background Transnasal endoscopy presents a technical difficulty when inserting the flexible endoscope. It is unclear whether a particular breathing method is useful for transnasal endoscopy. Therefore, we conducted a prospective randomized controlled
Autor:
Takahiro Sasaki, Kyoko Uehara, Shiro Yokohama, Shin Kashima, Hiroki Tanabe, Chisato Ishikawa, Mishie Tanino, Masaki Taruiishi, Yuki Murakami, Naoyuki Yanagida, Kentaro Moriichi, Yasuo Sumi, Hiromitsu Akabane, Mitsuru Goto, Katsuyoshi Ando, Mikihiro Fujiya, Sayaka Yuzawa, Yu Kobayashi, Takehito Kunogi, Yuya Sugiyama, Toshikatsu Okumura, Yohei Kitano, Keisuke Sato, Kazuyuki Tanaka, Nobuhiro Ueno, Hiroki Sato, Keitaro Takahashi, Kimiharu Hasegawa, Yusuke Mizukami
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 11, Iss 2, Pp 406-416 (2022)
Cancer Medicine, Vol 11, Iss 2, Pp 406-416 (2022)
Background Chemotherapy for advanced gastric cancer is recommended in the guidelines; however, later‐line treatment remains controversial. Since immune checkpoint inhibitors have been used for the treatment of various malignancies, trials have been
Autor:
Keitaro Takahashi, Takahiro Sasaki, Nobuhiro Ueno, Kyoko Uehara, Yu Kobayashi, Yuya Sugiyama, Yuki Murakami, Takehito Kunogi, Katsuyoshi Ando, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Toshikatsu Okumura, Mikihiro Fujiya
Publikováno v:
Surgical endoscopy. 36(10)
Background Carbazochrome sodium sulfonate (CSS) is conventionally administered to prevent post-endoscopic submucosal dissection (ESD) bleeding in many institutions, but research on its preventive efficacy is lacking. Therefore, we investigated the ri
Autor:
Charles R. Dean, Kyoko Uehara, Srijan Ranjitkar, Angela L. Woods, Adriana K. Jones, Katherine V. Thompson, S. Whitney Barnes, Lili Xie, Patrick Lee, John R. Walker, Ruth E. Caughlan
Publikováno v:
Antimicrob Agents Chemother
Upregulated expression of efflux pumps, lpxC target mutations, LpxC protein overexpression, and mutations in fabG were previously shown to mediate single-step resistance to the LpxC inhibitor CHIR-090 in P. aeruginosa. Single-step selection experimen
Autor:
Colin K. Skepper, Robert J. Moreau, Brent A. Appleton, Bret M. Benton, Joseph E. Drumm, Brian Y. Feng, Mei Geng, Cheng Hu, Cindy Li, Andreas Lingel, Yipin Lu, Mulugeta Mamo, Wosenu Mergo, Mina Mostafavi, Christopher M. Rath, Micah Steffek, Kenneth T. Takeoka, Kyoko Uehara, Lisha Wang, Jun-Rong Wei, Lili Xie, Wenjian Xu, Qiong Zhang, Javier de Vicente
Publikováno v:
Journal of Medicinal Chemistry. 61:3325-3349
In the preceding manuscript [ Moreau et al. 2018 , 10.1021/acs.jmedchem.7b01691 ] we described a successful fragment-based lead discovery (FBLD) strategy for discovery of bacterial phosphopantetheine adenylyltransferase inhibitors (PPAT, CoaD). Follo
Autor:
Anke Blechschmidt, Brent A. Appleton, M. Geng, Jun-Rong Wei, J. de Vicente, Colin K. Skepper, Mika Lindvall, Bret Benton, Lili Xie, Brian Y. Feng, Carl J. Balibar, Qiong Zhang, Lisha Wang, Mulugeta Mamo, Valery Polyakov, Andreas Weiss, J.E. Drumm, Cindy Li, Wosenu Mergo, T.M. Smith, Kenneth T. Takeoka, Wenjian Xu, Kyoko Uehara, Yipin Lu, Robert J. Moreau, Andreas Lingel
Publikováno v:
Journal of Medicinal Chemistry. 61:3309-3324
The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria are a major challenge with fundamental importance to our global healthcare system. Part of our broad