CONTROL OF SLEEP PREPARATORY BEHAVIOUR AND SLEEP INDUCTION BY PREFRONTAL CORTEX INHIBITORY NEURONS

Autor: Kyoko Tossell, Xiao Yu, Panagiotis Giannos, Mathieu Nollet, Nicholas Franks, William Wisden

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S30- (2023)

Externí odkaz: https://doaj.org/article/73d0cd55f47b42168005a7719e5198d0

Tonic GABAergic inhibition, via GABAA receptors containing αβƐ subunits, regulates excitability of ventral tegmental area dopamine neurons

Autor: Mark A. Ungless, Olga Tkachuk, Rakesh A. Dodhia, Benjamin Galet, Kyoko Tossell

Publikováno v: The European Journal of Neuroscience

The activity of midbrain dopamine neurons is strongly regulated by fast synaptic inhibitory γ‐Aminobutyric acid (GABA)ergic inputs. There is growing evidence in other brain regions that low concentrations of ambient GABA can persistently activate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b740a90a9bb4ac36f89bd00d2f9ef20e
http://europepmc.org/articles/PMC8651010

Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine

Autor: Michelle Kokkinou, Sridhar Natesan, Kyoko Tossell, Seth C. Hopkins, David R. Bonsall, Dominic J. Withers, Mark A. Ungless, Eleanor J. Paul, Nina Dedic, Mark A. Smith, Elaine E. Irvine, Justyna A. Glegola, Oliver D. Howes, Lisa Wells, Sanjay Khadayate, Mattia Veronese

Publikováno v: Molecular Psychiatry
Howes, O, Kokkinou, M, Natesan, S, Irving, E, Bonsall, D R, Wells, L A, Smith, M, Glegola, J, Paul, E, Tossell, K, Veronese, M, Khadayate, S, Dedic, N, Hopkins, S, Ungless, M A & Withers, D J 2020, ' Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it : a translational imaging study with ketamine ', Molecular Psychiatry, vol. 0, no. 0, pp. 1-15 . https://doi.org/10.1038/s41380-020-0740-6

Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV) neuronal dysfunctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdda13867bfbd9b976fa45cddd77d3b
http://europepmc.org/articles/PMC8440182

NMDA Receptors in the Lateral Preoptic Hypothalamus Are Essential for Sustaining NREM and REM Sleep

Autor: Giulia Miracca, Berta Anuncibay-Soto, Kyoko Tossell, Raquel Yustos, Alexei L. Vyssotski, Nicholas P. Franks, William Wisden

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 42(27)

The lateral preoptic (LPO) hypothalamus is a center for NREM and REM sleep induction and NREM sleep homeostasis. Although LPO is needed for NREM sleep, we found that calcium signals were, surprisingly, highest in REM sleep. Furthermore, and equally s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda16fea4d16e2d1036cc782d3544de3
https://pubmed.ncbi.nlm.nih.gov/35649726

Hypothalamic NMDA receptors stabilize NREM sleep and are essential for REM sleep

Autor: Nicholas P. Franks, Raquel Yustos, B. Anuncibay Soto, Giulia Miracca, William Wisden, Alexei L. Vyssotski, Kyoko Tossell

SUMMARYThe preoptic hypothalamus regulates both NREM and REM sleep. We found that calcium levels in mouse lateral preoptic (LPO) neurons were highest during REM. Deleting the core GluN1 subunit of NMDA receptors from LPO neurons abolished calcium sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::990b939ae9ee5bc9bb20dc83a32aae9f
https://doi.org/10.1101/2020.10.19.345728