Výsledky vyhledávání - "Kyoko Minowa"

The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF

Autor: Akiko Ohkawa, Kyoko Minowa, Yasuhiro Abe, Shin-ichi Tsunoda, Tetsuya Nomura, Shinsaku Nakagawa, Haruhiko Kamada, Yohei Mukai, Tsunetaka Ohta, Yasuo Yoshioka, Yasuo Tsutsumi, Hiroko Shibata, Madoka Taniai

Publikováno v: Biomaterials. 30:6638-6647

Blocking the binding of TNF-alpha to TNF receptor subtype-1 (TNFR1) is an important strategy for the treatment of rheumatoid arthritis (RA). We recently succeeded in developing a TNFR1-selective antagonistic TNF mutant, R1antTNF. Here, we report the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a80d1fe84312a5b3f67deb427ff5951
https://doi.org/10.1016/j.biomaterials.2009.08.041

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Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46

Autor: Tetsuya Nomura, Toshiki Sugita, Hiromi Nabeshi, Kazuya Nagano, Yasuhiro Abe, Tomoaki Yoshikawa, Norio Itoh, Kyoko Minowa, Yasuo Tsutsumi, Takuya Yamashita, Hiroko Shibata, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Yoshioka

Publikováno v: Biological and Pharmaceutical Bulletin. 32:1286-1288

Adult T-cell leukemia (ATL) is a severe chemotherapy-resistant malignancy associated with prolonged infection by the human T cell-lymphotropic virus 1 (HTLV-1). One approach to prevent the onset of ATL is to inhibit the growth/transmission of HTLV-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55453a7741c09881404de6db79f543de
https://doi.org/10.1248/bpb.32.1286

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Gravitational Stress‐Induced Dislocations in Large‐Diameter Silicon Wafers Studied by X‐Ray Topography and Computer Simulation

Autor: Kyoko Minowa, Seiichi Isomae, Tadashi Suzuki, Tomomi Satoh, Hirofumi Shimizu

Publikováno v: Journal of The Electrochemical Society. 145:2523-2529

Dislocations in slip bands introduced under gravitational stress in 200 mm diam Czochralski-grown silicon wafers were characterized by X-ray topography, and slip band initiation was estimated by computer simulation for 300 mm diam wafers. Surface scr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03958de069a4b593587940424b0985bf
https://doi.org/10.1149/1.1838672

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Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity

Autor: Shin-ichi Tsunoda, Yohei Mukai, Tetsuya Nomura, Yasuhiro Abe, Hiroyuki Miyoshi, Haruhiko Kamada, Hiroko Shibata, Hiroyuki Kayamuro, Tomoaki Yoshikawa, Shinsaku Nakagawa, Kazufumi Katayama, Yasuo Yoshioka, Yasuo Tsutsumi, Kyoko Minowa

Publikováno v: Journal of immunological methods. 335(1-2)

Drugs that target tumor necrosis factor-alpha (TNF) are particularly important in the treatment of severe inflammatory progression in rheumatoid arthritis, Crohn's disease and psoriasis. Despite the central role of the TNF/TNF receptor (TNFR) in vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d634087978be9800b27815efa35d60
https://pubmed.ncbi.nlm.nih.gov/18417150

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Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants

Autor: Tetsuya Nomura, Yasuo Tsutsumi, Tadanori Mayumi, Kyoko Kobayashi-Nishibata, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuhiro Abe, Yohei Mukai, Toshihide Nishibata, Hiromi Nabeshi, Kyoko Minowa, Hiroko Shibata, Shinsaku Nakagawa, Yasuo Yoshioka

Publikováno v: Biochimica et biophysica acta. 1774(8)

We have previously produced two bioactive lysine-deficient mutants of TNF-alpha (mutTNF-K90R,-K90P) and found that these mutants have bioactivity superior to wild-type TNF (wtTNF). Because these mutants contained same amino acid except for amino acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d67a6bec713bf2274bb4139b4a39c14
https://pubmed.ncbi.nlm.nih.gov/17561456

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Stress-induced amorphization of silicon crystal by mechanical scratching

Autor: Koji Sumino, Kyoko Minowa

Publikováno v: Physical Review Letters. 69:320-322

The damaged layer induced in a silicon crystal by surface scratching at room temperature under a light load was found, by transmission electron microscopy, to be a small amorphous region surrounded by a dislocated crystalline region. No dent was dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6397245a6dc07b79f5cbf41e4cd7c3
https://doi.org/10.1103/physrevlett.69.320

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Computer simulation for estimation of dislocation multiplication due to gravitational stress: challenges and opportunities toward slip-free 300-mm-diameter silicon wafers for ultralarge-scale integr

Autor: Kyoko Minowa, Hirofumi Shimizu, Seiichi Isomae, Tomomi Satoh

Publikováno v: SPIE Proceedings.

Considering the coming 300-mm-dia Si wafer era (beyond 0.25 - 0.18 micrometers design rule in MOS devices), occurrence of slip dislocations along directions due to gravitational stress at supporting jigs is still one of the biggest crucial issues in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a75f24774802f93630e67aaaafa592f2
https://doi.org/10.1117/12.284678

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