Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kyoko Kakumoto"'
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0119015 (2015)
The activity of the mechanistic target of rapamycin (mTOR) is elevated in various types of human cancers, implicating a role in tumor progression. However, the molecular mechanisms underlying mTOR upregulation remain unclear. In this study, we found
Externí odkaz:
https://doaj.org/article/793924c6ecdd4200a0ae2bd5d2234d1a
Autor:
Chitose Oneyama, Yoriko Kito, Rei Asai, Jun-ichiro Ikeda, Takuya Yoshida, Daisuke Okuzaki, Rie Kokuda, Kyoko Kakumoto, Ken-ichi Takayama, Satoshi Inoue, Eiichi Morii, Masato Okada
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80300 (2013)
mTOR complex 2 (mTORC2) signaling is upregulated in multiple types of human cancer, but the molecular mechanisms underlying its activation and regulation remain elusive. Here, we show that microRNA-mediated upregulation of Rictor, an mTORC2-specific
Externí odkaz:
https://doaj.org/article/8670d7cb97c449a39cb6314a7ccd8123
Autor:
Junji Yamaguchi, Tetsu Yoshida, Yasuo Uchiyama, Ayumu Konno, Robert B. Darnell, Kyoko Kakumoto, Hirokazu Hirai, Masahiko Watanabe, Ken-ichiro Kuwako, Hideyuki Okano, Jun-ichi Hata, Taisuke Miyazaki, Yuki Ogawa, Hirotaka James Okano
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Neuronal Elav-like (nElavl or neuronal Hu) proteins are RNA-binding proteins that regulate RNA stability and alternative splicing, which are associated with axonal and synaptic structures. nElavl proteins promote the differentiation and maturation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2422af195c6e0d39d1fd3a1638ac41
https://doi.org/10.1038/s41598-018-21130-5
https://doi.org/10.1038/s41598-018-21130-5
Publikováno v:
Journal of Japan Academy of Nursing Science. 29:69-78
重症心身障害児（者）看護の質向上に資するため，重症心身障害児施設で働く看護師が経験を基盤に親への関わりにおける認識と実践を変化させていくプロセスを記述することを目的に
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1058801fbf69461bf10f58e29bfbd1c7
https://doi.org/10.5630/jans.29.4_69
https://doi.org/10.5630/jans.29.4_69
Publikováno v:
Oncogene. 26:449-455
Normal human diploid fibroblasts (HDFs) are refractory to oncogene-mediated transformations in vitro, compared with rodent fibroblasts. As successful oncogene-mediated transformations of normal HDFs have been reported using the human telomerase catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92e5ce2f25d6b53cff67f0786336fae
https://doi.org/10.1038/sj.onc.1209792
https://doi.org/10.1038/sj.onc.1209792
Autor:
Kunimi Kikuchi, Kyoko Kakumoto, Hiroshi Shima, Chiaki Katagiri, Miyuki Nomura, Tsuyoshi Akagi, Kouhei Masuda, Masami Sato, Nobuhiro Tanuma
Publikováno v:
Biochemical and biophysical research communications. 393(2)
MAPK phosphatase-7 (MKP-7) was identified as a JNK-specific phosphatase. However, despite its high specificity for JNK, MKP-7 interacts also with ERK. We previously showed that as a physiological consequence of their interaction, activated ERK phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52eb1d92fe4cf5dc055f8c17dd711403
https://pubmed.ncbi.nlm.nih.gov/20122898
https://pubmed.ncbi.nlm.nih.gov/20122898
Autor:
Kana Shibutani, Satoshi Ishimaru, Tsuyoshi Akagi, Hidesaburo Hanafusa, Chitose Oneyama, Ken Sasai, Hiroto Mizushima, Eisuke Mekada, Kyoko Kakumoto, Taiko Sukezane
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 103(14)
Human diploid fibroblasts (HDF) immortalized by hTERT and simian virus 40 (SV40) early region (ER) exhibit a limited degree of transformation upon the expression of activated H-RAS (H-RAS V12) compared with rat embryonic fibroblasts (REF) immortalize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14824f3230fc03289fc65e4bb3e6729e
https://pubmed.ncbi.nlm.nih.gov/16569692
https://pubmed.ncbi.nlm.nih.gov/16569692
Autor:
Hidesaburo Hanafusa, Chitose Oneyama, Kana Shibutani, Taiko Sukezane, Kyoko Kakumoto, Tsuyoshi Akagi
Publikováno v:
Oncogene. 24(36)
Ras-induced transformation is characterized not only by uncontrolled proliferation but also by drastic morphological changes accompanied by the disruption of the actin cytoskeleton. Previously, we reported that human fibroblasts are more resistant th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8302dffe4f040fb42db74eca5c5544e5
https://pubmed.ncbi.nlm.nih.gov/16007212
https://pubmed.ncbi.nlm.nih.gov/16007212
Autor:
Robert B. Darnell, Hirotaka James Okano, Kyoko Kakumoto, Taisuke Miyazaki, Masahiko Watanabe, Hideyuki Okano
Publikováno v:
Neuroscience Research. 71:e95-e96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ef65728fd8e824dfab63770faa1198f
https://doi.org/10.1016/j.neures.2011.07.410
https://doi.org/10.1016/j.neures.2011.07.410
Autor:
Ken-ichi Takayama, Satoshi Inoue, Masato Okada, Chitose Oneyama, Rie Kokuda, Takuya Yoshida, Daisuke Okuzaki, Jun-ichiro Ikeda, Rei Asai, Eiichi Morii, Kyoko Kakumoto, Yoriko Kito
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 11, p e80300 (2013)
PLoS ONE, Vol 8, Iss 11, p e80300 (2013)
mTOR complex 2 (mTORC2) signaling is upregulated in multiple types of human cancer, but the molecular mechanisms underlying its activation and regulation remain elusive. Here, we show that microRNA-mediated upregulation of Rictor, an mTORC2-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77e67ae46914c45b7731511f0725350
https://doi.org/10.1371/journal.pone.0080300
https://doi.org/10.1371/journal.pone.0080300