Výsledky vyhledávání

Pharmacokinetics of a novelN-methyl-D-aspartate receptor antagonist (SM-18400): Identification of anN-acetylated metabolite and pre-clinical assessment ofN-acetylation polymorphism

Autor: Masaki Kataoka, Iwao Nakatsuka, Yutaka Kon-Ya, Hiroshi Kanamaru, Masaki Ito, Masashi Yabuki, Kyoko Akao, Takeshi Shimizudani

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 28:21-29

(S)-9-chloro-5-[p-aminomethyl-o-(carboxymethoxy)phenylcarbamoylmethyl]-6,7-dihydro-1 H,5 H-pyrido[1,2,3-de]quinoxaline-2,3-dione hydrochloride trihydrate (SM-18400) was given intravenously to rats and dogs and its pharmacokinetics was investigated. B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249856b6af89e9e9d50c4dde4a17615c
https://doi.org/10.1007/bf03190863

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Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (III): Blood Concentration, Distribution, Metabolism and Excretion after a Single Intravenous Administration to Dogs

Autor: Shunji NAKAI, Kyoko AKAO, Masaki ITO, Setsuko KOMURO, Hiroshi KANAMARU, Iwao NAKATSUKA

Publikováno v: Drug Metabolism and Pharmacokinetics. 13:91-99

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34b1dd0dec06be678735516860d85a2d
https://doi.org/10.2133/dmpk.13.91

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Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (II): Blood Concentration, Distribution, Metabolism and Excretion after Repeated Intravenous Administration to Rats

Autor: Shunji NAKAI, Kyoko AKAO, Masaki ITO, Hiroshi KANAMARU, Iwao NAKATSUKA

Publikováno v: Drug Metabolism and Pharmacokinetics. 13:78-90

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f4302288eafab58402ea5ef58b03a18
https://doi.org/10.2133/dmpk.13.78

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Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (IV): Metabolism of SM-5887 in Rats and Dogs

Autor: Shunji Nakai, Iwao Nakatsuka, Masaki Ito, Kyoko Akao, Hiroshi Kanamaru

Publikováno v: Drug Metabolism and Pharmacokinetics. 13:100-112

The metabolism of amrubicin hydrochloride (SM-5887), a novel antitumor agent, was investigated in rats and dogs after intravenous administration of 14C-labeled SM-5887. 1. Nine metabolites in rat urine, ten metabolites in rat bile, six metabolites in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cf1aecc3e67bedd3534b471c1a8d610
https://doi.org/10.2133/dmpk.13.100

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Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (I): Blood Concentration, Distribution, Metabolism and Excretion after a Single Intravenous Administration to Rats

Autor: Shunji NAKAI, Kyoko AKAO, Masaki ITO, Yoshiko MIZUNO, Setsuko KOMURO, Hiroshi KANAMARU, Iwao NAKATSUKA, Yoshio ESUMI, Masao ISHIZAKI, Shinobu GUNJI, Atsushi TAKAO, Kazue KIMURA, Tomoko NAKAYAMA, Shinichi NINOMIYA

Publikováno v: Drug Metabolism and Pharmacokinetics. 13:61-77

Pharmacokinetics on plasma and blood cells concentration, tissue distribution and excretion of amrubicin hydrochloride (SM-5887), a novel antitumor agent, were investigated after a single intravenous administration of 14C-labeled SM-5887 at the doses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbdbd9ad00e8df4ebccfbd9e0322f337
https://doi.org/10.2133/dmpk.13.61

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