A Phase Ib Study of Durvalumab (MEDI4736) in Combination with Carbon-Ion Radiotherapy and Weekly Cisplatin for Patients with Locally Advanced Cervical Cancer (DECISION Study): The Early Safety and Efficacy Results

Autor: Usui, Noriyuki Okonogi, Kazutoshi Murata, Shigeru Yamada, Yuji Habu, Makoto Hori, Tomoya Kurokawa, Yosuke Inaba, Tadami Fujiwara, Yasuhisa Fujii, Michiko Hanawa, Yohei Kawasaki, Yoko Hattori, Kazuko Suzuki, Kyoko Tsuyuki, Masaru Wakatsuki, Masashi Koto, Sumitaka Hasegawa, Hitoshi Ishikawa, Hideki Hanaoka, Makio Shozu, Hiroshi Tsuji, Hirokazu

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10565

We conducted a phase Ib study to examine the safety of a combination of carbon-ion RT (CIRT) with durvalumab (MEDI4736; AstraZeneca) in patients with locally advanced cervical cancer. This was an open-label, single-arm study with a modified 3 + 3 des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::49cca5feb6f5d38a2e71c3b4edc475d1

Phase Ib study of durvalumab (MEDI4736) in combination with carbon-ion radiotherapy and weekly cisplatin for patients with locally advanced cervical cancer (DECISION study): study protocol for a prospective open-label single-arm study

Autor: Noriyuki Okonogi, Hirokazu Usui, Kazutoshi Murata, Makoto Hori, Tomoya Kurokawa, Tadami Fujiwara, Yasuhisa Fujii, Michiko Hanawa, Yohei Kawasaki, Yoko Hattori, Kazuko Suzuki, Kyoko Tsuyuki, Masaru Wakatsuki, Sumitaka Hasegawa, Shigeru Yamada, Hideki Hanaoka, Makio Shozu, Hiroshi Tsuji

Publikováno v: BMJ Open. 12:e056424

IntroductionConcurrent chemoradiotherapy is considered the standard treatment strategy for locally advanced cervical cancer. Most recent reports indicate that patients with bulky tumours or adenocarcinoma subtypes have poorer local control. Carbon-io

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa95bb09c6a38693bd3dcfc043407ad9
https://doi.org/10.1136/bmjopen-2021-056424

A Phase Ib Study of Durvalumab (MEDI4736) in Combination with Carbon-Ion Radiotherapy and Weekly Cisplatin for Patients with Locally Advanced Cervical Cancer (DECISION Study): The Early Safety and Efficacy Results.

Autor: Okonogi, Noriyuki¹ (AUTHOR) okonogi.noriyuki@qst.go.jp, Murata, Kazutoshi¹ (AUTHOR) murata.kazutoshi@qst.go.jp, Yamada, Shigeru¹ (AUTHOR) suzuki.kazuko@qst.go.jp, Habu, Yuji² (AUTHOR) habuyujp@yahoo.co.jp, Hori, Makoto³ (AUTHOR) makotohori@chiba-u.jp, Kurokawa, Tomoya³ (AUTHOR) t-kurokawa@chiba-u.jp, Inaba, Yosuke³ (AUTHOR) y.inaba@chiba-u.jp, Fujiwara, Tadami³ (AUTHOR) t-fujiwara@chiba-u.jp, Fujii, Yasuhisa³ (AUTHOR) fujiiya1@faculty.chiba-u.jp, Hanawa, Michiko³ (AUTHOR) m-hanawa@chiba-u.jp, Kawasaki, Yohei⁴ (AUTHOR) y-kawasaki@redcross.ac.jp, Hattori, Yoko³ (AUTHOR) hattori@chiba-u.jp, Suzuki, Kazuko¹ (AUTHOR) tsuyuki.kyoko@qst.go.jp, Tsuyuki, Kyoko¹ (AUTHOR) wakkun100@gmail.com, Wakatsuki, Masaru¹ (AUTHOR) koto.masashi@qst.go.jp, Koto, Masashi¹ (AUTHOR) ishikawa.hitoshi@qst.go.jp, Hasegawa, Sumitaka⁵ (AUTHOR) hasegawa.sumitaka@qst.go.jp, Ishikawa, Hitoshi¹ (AUTHOR) tsuji.hiroshi@qst.go.jp, Hanaoka, Hideki³ (AUTHOR) hanaoka.hideki@faculty.chiba-u.jp, Shozu, Makio² (AUTHOR) shozumakio@chiba-u.jp

Publikováno v: International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 13, p10565. 10p.