Výsledky vyhledávání - "Kyoko, Nakano"

Scientific and Regulatory Policy Committee Best Practices: Recommended ('Best') Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies

Autor: Brad Bolon, Sabine Francke, Jessica M. Caverly Rae, Evelyne Polack, Karen S. Regan, Elizabeth F. McInnes, Jamie K. Young, Kevin Keane, Rick Perry, Annette Romeike, Karyn Colman, Karl Jensen, Kyoko Nakano-Ito, Elizabeth J. Galbreath

Publikováno v: Toxicologic pathology. 50(8)

This article describes the Society of Toxicologic Pathology’s (STP) five recommended (“best”) practices for appropriate use of informed (non-blinded) versus masked (blinded) microscopic evaluation in animal toxicity studies intended for regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de9dc26cd7c988521940b0bd21e36a9
https://pubmed.ncbi.nlm.nih.gov/36377245

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Combination of circulating microRNAs as indicators of specific targets of retinal toxicity in rats

Autor: Etsuko Ohta, Kyoko Nakano-Ito, Yoshikazu Taketa, Satoru Hosokawa, Yasuhiro Fujikawa, Dai Kakiuchi, Shoji Asakura

Publikováno v: Toxicology. 411:163-171

Circulating miR-96-5p, -124-3p, and 183-5p have been reported as safety biomarkers for retinal toxicity. In the present research, 5 serum microRNAs (miRNAs), which are highly specific to and abundant in the retina, including the 3 miRNAs previously m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f467689f9cb425f058ec1fbeb0ce4ad
https://doi.org/10.1016/j.tox.2018.10.008

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Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors

Autor: Tetsushi Dodo, Keisuke Yamaguchi, Akane Komatsu, Kanako Miyano, Yasuhito Uezono, Yuji Kamikubo, Takashi Murayama, Masakazu Hayashida, Miki Nonaka, Haruo Ogawa, Nagomi Kurebayashi, Yui Kuroda, Masako Iseki, Takashi Sakurai, Kyoko Nakano-Ito, Hakushun Sakairi

Publikováno v: Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111800-(2021)

Background The misuse of opioids has led to an epidemic in recent times. The endothelin A receptor (ETAR) has recently attracted attention as a novel therapeutic target to enhance opioid analgesia. We hypothesized that endothelin A receptors may affe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd460aad40265498e8af173c756792b0
https://pubmed.ncbi.nlm.nih.gov/34175819

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Opinion on Current Use of Non-Blinded Versus Blinded Histopathologic Evaluation in Animal Toxicity Studies

Autor: Elizabeth F. McInnes, Karl F. Jensen, Jamie K. Young, Jessica Caverly Rae, Elizabeth Galbreath, Evelyne Polack, Brad Bolon, Karen S. Regan, Kevin A. Keane, Rick Perry, Annette Romeike, Karyn Colman, Kyoko Nakano-Ito, Sabine Francke

Publikováno v: Toxicologic pathology. 48(4)

The Society of Toxicologic Pathology (STP) explored current institutional practices for selecting between non-blinded versus blinded histopathologic evaluation during Good Laboratory Practice (GLP)-compliant, regulatory-type animal toxicity studies u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8695e1674c1af5bfbdfbff9a205523cb
https://pubmed.ncbi.nlm.nih.gov/32347786

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The effects of ethylene glycol monomethyl ether on female reproductive system in juvenile rats

Autor: Kyoko Nakano-Ito, Etsuko Ohta, Yoshikazu Taketa, Hiroshi Mineshima

Publikováno v: The Journal of Toxicological Sciences. 42:707-713

Ethylene glycol monomethyl ether (EGME), which is widely used in various industrial products, is known for adverse effects on the reproductive system in adult rats. However, the effects of EGME on reproductive development in juvenile rats have not be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5c679b58efa3d7ce711d00e9b63f42
https://doi.org/10.2131/jts.42.707

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Wif1 and Ifitm3 gene expression preferentially altered in the colon mucosa of benzo[a]pyrene pre-treated mice following exposure to dextran sulfate sodium

Autor: Satoru Hosokawa, Atsushi Hakura, Osamu Tohyama, Kyoko Nakano-Ito, Naoki Koyama, Naoki Toritsuka, Yuki Seki, Shoji Asakura, Jiro Sonoda

Publikováno v: Chemico-Biological Interactions. 240:164-170

Benzo[a]pyrene (BP) is highly mutagenic and yet does not lead to tumor development in the murine colon. We recently reported the generation of colonic tumors one week after treatment with BP followed by dextran sulfate sodium (DSS), a colitis-inducer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049b72eac5c43de695111c1af02d3ec5
https://doi.org/10.1016/j.cbi.2015.07.012

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Pregnancy and birth survey after the great East Japan earthquake and fukushima daiichi nuclear power plant accident in fukushima prefecture

Autor: Aya Goto, Keiya Fujimori, Mieko Sato, Kyoko Nakano, Hyo Kyozuka, Masafumi Abe, Kenichi Hata, Shun Yasuda, Akihito Nakai, Akira Ohtsuru, Shiro Matsui, Kouta Suzuki, Seiji Yasumura, Yasuhisa Nomura, Misao Ota

Publikováno v: Fukushima Journal of Medical Science. 60(1):75-81

Background: On 11 March 2011, the Great East Japan Earthquake followed by a powerful tsunami hit the Pacific Coast of Northeast Japan and damaged Tokyo Electric Power Company's Fukushima Daiichi Nuclear Power Plant, causing a radiation hazard in Fuku

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58eb897681819b1e926e6accbb5e5444
http://ir.fmu.ac.jp/dspace/handle/123456789/406

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