Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Kyoko, Furuita"'
Autor:
Ken-ichi Harada, Kyoko Furuita, Eiki Yamashita, Ken-ichiro Taoka, Hiroyuki Tsuji, Toshimichi Fujiwara, Atsushi Nakagawa, Chojiro Kojima
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract In potato (Solanum tuberosum L.), 14-3-3 protein forms a protein complex with the FLOWERING LOCUS T (FT)-like protein StSP6A and the FD-like protein StFDL1 to activate potato tuber formation. Eleven 14-3-3 isoforms were reported in potato, d
Externí odkaz:
https://doaj.org/article/0f9d64f41ed14723a832c4932a14ea11
Autor:
Ken‐ichiro Taoka, Ikumi Kawahara, Shoko Shinya, Ken‐ichi Harada, Eiki Yamashita, Zenpei Shimatani, Kyoko Furuita, Tomoaki Muranaka, Tokitaka Oyama, Rie Terada, Atsushi Nakagawa, Toshimichi Fujiwara, Hiroyuki Tsuji, Chojiro Kojima
Publikováno v:
The Plant Journal. 112:1337-1349
Structure-based high-throughput screening of chemical compounds that target protein-protein interactions (PPIs) is a promising technology for gaining insight into how plant development is regulated, leading to many potential agricultural applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992ce178351461fd77d824653e1a9f70
https://doi.org/10.1111/tpj.16008
https://doi.org/10.1111/tpj.16008
Autor:
Kyoko Furuita, Kouki Inomata, Toshihiko Sugiki, Naohiro Kobayashi, Toshimich Fujiwara, Chojiro Kojima
Publikováno v:
Biomolecular NMR Assignments. 16:267-271
Glutathione peroxidase 4 (GPx4) behaves as an antioxidant enzyme capable of directly reducing peroxidized phospholipids within cell membranes. Recently, GPx4 has attracted attention as a target molecule for cancer therapy because it induces the immor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13fd948e6160428f0d303bf71476ede
https://doi.org/10.1007/s12104-022-10090-7
https://doi.org/10.1007/s12104-022-10090-7
Autor:
Shoko Shinya, Ritsuko Katahira, Kyoko Furuita, Toshihiko Sugiki, Young-Ho Lee, Yoshikazu Hattori, Kohei Takeshita, Atsushi Nakagawa, Aoi Kokago, Ken-ichi Akagi, Muneki Oouchi, Fumiaki Hayashi, Takanori Kigawa, Midori Takimoto-Kamimura, Toshimichi Fujiwara, Chojiro Kojima
Publikováno v:
RSC Medicinal Chemistry. 13:1100-1111
19F-NMR analysis using the optimized 19F chemical library enables the modeling of the structure of the weakly bound protein–compound complex, overcoming the difficulty in fragment-based drug discovery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a4bd97cf852c69003c817b3f14ba2ec
https://doi.org/10.1039/d2md00170e
https://doi.org/10.1039/d2md00170e
Autor:
Takashi S. Kodama, Kyoko Furuita, Toshihiko Sugiki, Ken-ichi Akagi, Yoko Monobe, Yoshiaki Enokizono, Noriko Monden, Misaki Nakamura, Yoshikazu Hattori, Kohsuke Inomata, Masahiro Shirakawa, Hidehito Tochio, Toshimichi Fujiwara, Chojiro Kojima
With in-cell NMR, the structural and dynamic features of proteins can be analyzed directly in living cells at atomic resolution. However, in mammalian cells, such as human cells, the structural/dynamic features and physiological functions are not ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a836f1d42940e52bfadc4d47e3a9005e
https://doi.org/10.21203/rs.3.rs-2095218/v1
https://doi.org/10.21203/rs.3.rs-2095218/v1
Publikováno v:
FEBS Letters. 595:2248-2256
The endoplasmic reticulum transmembrane protein vesicle-associated membrane protein-associated protein (VAP) plays a central role in the formation and function of membrane contact sites (MCS) through its interactions with proteins. The major sperm pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be2d5861bea2f972f1f330493bb2b54
https://doi.org/10.1002/1873-3468.14166
https://doi.org/10.1002/1873-3468.14166
Autor:
Hisashi Tatebe, Shinichi Murayama, Toshiya Yonekura, Tomoyuki Hatano, David Richter, Tomomi Furuya, Saori Kataoka, Kyoko Furuita, Chojiro Kojima, Kazuhiro Shiozaki
Publikováno v:
eLife, Vol 6 (2017)
The target of rapamycin (TOR) protein kinase forms multi-subunit TOR complex 1 (TORC1) and TOR complex 2 (TORC2), which exhibit distinct substrate specificities. Sin1 is one of the TORC2-specific subunit essential for phosphorylation and activation o
Externí odkaz:
https://doaj.org/article/2c6864ba6df44826bced7e53c0746a6c
Autor:
Takeshi Yamada, Kyoko Furuita, Shuhei Sakurabayashi, Makoto Nomura, Chojiro Kojima, Kazuhiko Nakatani
Publikováno v:
Nucleic acids research. 50(17)
Trinucleotide repeat (TNR) diseases are caused by the aberrant expansion of CXG (X = C, A, G and T) sequences in genomes. We have reported two small molecules binding to TNR, NCD, and NA, which strongly bind to CGG repeat (responsible sequence of fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ca9bb5dc9ba4ea9cb181550cc6b8ba
https://pubmed.ncbi.nlm.nih.gov/36095126
https://pubmed.ncbi.nlm.nih.gov/36095126
Autor:
Shoko, Shinya, Ritsuko, Katahira, Kyoko, Furuita, Toshihiko, Sugiki, Young-Ho, Lee, Yoshikazu, Hattori, Kohei, Takeshita, Atsushi, Nakagawa, Aoi, Kokago, Ken-ichi, Akagi, Muneki, Oouchi, Fumiaki, Hayashi, Takanori, Kigawa, Midori, Takimoto-Kamimura, Toshimichi, Fujiwara, Chojiro, Kojima
Publikováno v:
RSC Medicinal Chemistry.
Fragment-based drug discovery (FBDD), which involves small compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::c3830ebf3051385a4b8f25201d1760e7
http://hdl.handle.net/10131/00014763
http://hdl.handle.net/10131/00014763
Publikováno v:
Molecules, Vol 23, Iss 1, p 148 (2018)
A variety of nuclear magnetic resonance (NMR) applications have been developed for structure-based drug discovery (SBDD). NMR provides many advantages over other methods, such as the ability to directly observe chemical compounds and target biomolecu
Externí odkaz:
https://doaj.org/article/64bf6d8d42ff40208cbb5ef95e577f35