Zobrazeno 1 - 10 of 70 pro vyhledávání: '"Kyoji Tsuchikama"'
1
Akademický článek
Enhanced anti-angiogenetic effect of transferrin receptor-mediated delivery of VEGF-trap in a glioblastoma mouse model
Autor: Peng Zhao, Yasuaki Anami, Peng Gao, Xuejun Fan, Leike Li, Kyoji Tsuchikama, Ningyan Zhang, Zhiqiang an
Publikováno v: mAbs, Vol 14, Iss 1 (2022)
Glioblastoma (GBM) is a common and aggressive brain cancer that accounts for 60% of adult brain tumors. Anti-angiogenesis therapy is an attractive option due to the high vasculature density of GBM. However, the best-known anti-angiogenic therapeutics
Externí odkaz: https://doaj.org/article/605dbefac98a4efba2de6c9aa8c56cc8
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2
Akademický článek
Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
Autor: Chisato M. Yamazaki, Aiko Yamaguchi, Yasuaki Anami, Wei Xiong, Yoshihiro Otani, Jangsoon Lee, Naoto T. Ueno, Ningyan Zhang, Zhiqiang An, Kyoji Tsuchikama
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Intratumor heterogeneity in breast cancer can limit the clinical success of antibody-drug conjugates (ADCs). In this study, the authors develop dual payload Her2-ADCs that show potent anti-tumor activity against heterogeneous breast tumors in vivo.
Externí odkaz: https://doaj.org/article/89230ea929c14625992165bf821e7857
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3
Akademický článek
Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice
Autor: Yasuaki Anami, Chisato M. Yamazaki, Wei Xiong, Xun Gui, Ningyan Zhang, Zhiqiang An, Kyoji Tsuchikama
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The valine-citrulline dipeptide, which is used as a cleavable linker for antibody-drug conjugates, is instable in mouse plasma. Here, the authors developed a glutamic acid–valine–citrulline tripeptide sequence as a stable alternative that still i
Externí odkaz: https://doaj.org/article/8436b2df5ee445a5b2278b4b789128d3
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8
An enzymatically cleavable tripeptide linker for maximizing the therapeutic index of antibody-drug conjugates
Autor: Summer Y.Y. Ha, Yasuaki Anami, Chisato M. Yamazaki, Wei Xiong, Candice M. Haase, Scott D. Olson, Jangsoon Lee, Naoto T. Ueno, Ningyan Zhang, Zhiqiang An, Kyoji Tsuchikama
Publikováno v: Mol Cancer Ther
Valine–citrulline is a protease-cleavable linker commonly used in many drug delivery systems, including antibody–drug conjugates (ADC) for cancer therapy. However, its suboptimal in vivo stability can cause various adverse effects such as neutrop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227cbbb36383cf33408da8a447a39b13
https://europepmc.org/articles/PMC9452487/
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9
Total Synthesis of the Monomeric Unit of Lomaiviticin A
Autor: Yasuaki Anami, Qifeng Chen, Kyriacos C. Nicolaou, Kyoji Tsuchikama, Ruofan Li
Publikováno v: Journal of the American Chemical Society. 142:20201-20207
The architecturally symmetrical and synthetically challenging marine natural products lomaiviticins A and B present alluring synthetic targets due to their molecular complexity, potent antitumor properties, and natural scarcity. Herein, we report the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d186e64f3dfb766d8d865a2f30486502
https://doi.org/10.1021/jacs.0c10660
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