Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Kyoji Urayama"'
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Akademický článek
The Body-wide Transcriptome Landscape of Disease Models
Autor: Satoshi Kozawa, Ryosuke Ueda, Kyoji Urayama, Fumihiko Sagawa, Satsuki Endo, Kazuhiro Shiizaki, Hiroshi Kurosu, Glicia Maria de Almeida, Sharif M. Hasan, Kiyokazu Nakazato, Shinji Ozaki, Yoshinori Yamashita, Makoto Kuro-o, Thomas N. Sato
Publikováno v: iScience, Vol 2, Iss , Pp 238-268 (2018)
Summary: Virtually all diseases affect multiple organs. However, our knowledge of the body-wide effects remains limited. Here, we report the body-wide transcriptome landscape across 13–23 organs of mouse models of myocardial infarction, diabetes, k
Externí odkaz: https://doaj.org/article/40d692930b7c4ec6be5e8d98e5c5efff
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2
Latent disease similarities and therapeutic repurposing possibilities uncovered by multi-modal generative topic modeling of human diseases
Autor: Satoshi Kozawa, Hirona Yokoyama, Kyoji Urayama, Kengo Tejima, Hotaka Doi, Shunki Takagi, Thomas N Sato
Publikováno v: Bioinformatics Advances. 3
Motivation Human diseases are characterized by multiple features such as their pathophysiological, molecular and genetic changes. The rapid expansion of such multi-modal disease-omics space provides an opportunity to re-classify diverse human disease
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3facc80b25e8392ecde35163c614ba78
https://doi.org/10.1093/bioadv/vbad047
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3
Akademický článek
Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1.
Autor: Adeline Gasser, Simone Brogi, Kyoji Urayama, Toshishide Nishi, Hitoshi Kurose, Andrea Tafi, Nigel Ribeiro, Laurent Désaubry, Canan G Nebigil
Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0121027 (2015)
Prokineticins are angiogenic hormones that activate two G protein-coupled receptors: PKR1 and PKR2. PKR1 has emerged as a critical mediator of cardiovascular homeostasis and cardioprotection. Identification of non-peptide PKR1 agonists that contribut
Externí odkaz: https://doaj.org/article/0411055ec63f4702b222f4efe0f7443b
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4
Pressure Overload–Mediated Sustained PKR2 (Prokineticin-2 Receptor) Signaling in Cardiomyocytes Contributes to Cardiac Hypertrophy and Endotheliopathies
Autor: Anais Audebrand, Canan G. Nebigil, Ayca Toprak-Semiz, Kyoji Urayama, Marja Steenman, Ferda Demir, Hitoshi Kurose
Publikováno v: Hypertension
Hypertension, American Heart Association, 2021, 77 (5), pp.1559-1570. ⟨10.1161/HYPERTENSIONAHA.120.16808⟩
Hypertension, American Heart Association, 2021, 77 (5), ⟨10.1161/HYPERTENSIONAHA.120.16808⟩
Hypertension, 2021, 77 (5), pp.1559-1570. ⟨10.1161/HYPERTENSIONAHA.120.16808⟩
Hypertension, 2021, 77 (5), ⟨10.1161/HYPERTENSIONAHA.120.16808⟩
Chronic cardiac pressure overload, caused by conditions, such as hypertension, induces pathological hypertrophic growth of myocardium and vascular rarefaction, with largely unknown mechanisms. Here, we described that expression of the PKR2 (prokineti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b0c60549022e3b0cebe31fb792e09c
https://hal.archives-ouvertes.fr/hal-03439191
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5
Akademický článek
An anthelmintic drug, pyrvinium pamoate, thwarts fibrosis and ameliorates myocardial contractile dysfunction in a mouse model of myocardial infarction.
Autor: Motoaki Murakoshi, Kyohei Saiki, Kyoji Urayama, Thomas N Sato
Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79374 (2013)
Metabolic adaptation to limited supplies of oxygen and nutrients plays a pivotal role in health and disease. Heart attack results from insufficient delivery of oxygen and nutrients to the heart, where cardiomyocytes die and cardiac fibroblasts prolif
Externí odkaz: https://doaj.org/article/1b7371e23f954a7ab323aa38e43ea298
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6
The Body-wide Transcriptome Landscape of Disease Models
Autor: Makoto Kuro-o, Ryosuke Ueda, Glicia Maria de Almeida, Kyoji Urayama, Satsuki Endo, Satoshi Kozawa, Shinji Ozaki, Fumihiko Sagawa, Kazuhiro Shiizaki, Yoshinori Yamashita, Hiroshi Kurosu, Sharif Hasan, Thomas N. Sato, Kiyokazu Nakazato
Publikováno v: iScience, Vol 2, Iss, Pp 238-268 (2018)
Summary: Virtually all diseases affect multiple organs. However, our knowledge of the body-wide effects remains limited. Here, we report the body-wide transcriptome landscape across 13–23 organs of mouse models of myocardial infarction, diabetes, k
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053cf49f9b3950be3ce27e406423bdcb
https://doi.org/10.1016/j.isci.2018.03.014
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7
Gα12/13- and Reactive Oxygen Species-dependent Activation of c-Jun NH2-terminal Kinase and p38 Mitogen-activated Protein Kinase by Angiotensin Receptor Stimulation in Rat Neonatal Cardiomyocytes
Autor: Taku Nagao, Justin H. Turner, Tohru Kozasa, Yuichi Nagamatsu, Kyoji Urayama, Yoji Sato, Motohiro Nishida, Toru Kawanishi, Ryuji Inoue, Supachoke Mangmool, Yoshiko Maruyama, Shihori Tanabe, Hitoshi Kurose, Hiroyuki Kobayashi, Shuichi Takagahara
Publikováno v: Journal of Biological Chemistry. 280:18434-18441
In the present study, we examined signal transduction mechanism of reactive oxygen species (ROS) production and the role of ROS in angiotensin II-induced activation of mitogen-activated protein kinases (MAPKs) in rat neonatal cardiomyocytes. Among th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a286228d3d8f2d8f4d1922707ea5365f
https://doi.org/10.1074/jbc.m409710200
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9
0365: Non-peptidic prokineticin receptor 1 agonist as a novel cardioprotective therapeutic
Autor: Andrea Tafi, Hitoshi Kurose, Laurent Désaubry, Thu Lan Nguyen, Simone Brogi, Adeline Gasser, Kyoji Urayama, Canan G. Nebigil, Toshihide Nishi, Marine Charavin
Objective Prokineticins are potent angiogenic peptides that bind to two G protein-coupled receptors to initiate their biological effects. We previously have shown that prokineticin receptor-1 (PKR1) signaling contributes to cardiomyocyte survival or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082a3398c6982e0ee0398c2a1cc1eff5
http://hdl.handle.net/11568/993657
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10
J Am Heart Assoc
Autor: Daniel Henrion, Gilles Renault, Thu Lan Nguyen, Kyoji Urayama, Mounia Boulberdaa, Gulen Turkeri, Nadia Messaddeq, Mojdeh Dormishian, Canan G. Nebigil
Publikováno v: Journal of the American Heart Association
Journal of the American Heart Association, Wiley-Blackwell, 2013, 2 (5), ⟨10.1161/JAHA.113.000411⟩
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association, Wiley-Blackwell, 2013, 2 (5), Non spécifié. ⟨10.1161/JAHA.113.000411⟩
Scopus-Elsevier
Journal of the American Heart Association, 2013, 2 (5), Non spécifié. ⟨10.1161/JAHA.113.000411⟩
Background Reciprocal relationships between endothelial dysfunction and insulin resistance result in a vicious cycle of cardiovascular, renal, and metabolic disorders. The mechanisms underlying these impairments are unclear. The peptide hormones prok
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4857c5760bf7ce6d1640ee6783be98d2
https://doi.org/10.1161/jaha.113.000411
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