Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kyohei Horie"'
Autor:
Masanobu Kanou, Katsuyuki Nakamura, Kyohei Horie, Hiroshi Sakai, Yuta Yanagihara, Iori Sakakibara, Kei Yamana, Yuuki Imai
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 1, Pp 57-74 (2021)
Abstract Background Muscle wasting is a common condition concomitant with aging. Androgens significantly increase skeletal muscle mass, but the role of the androgen receptor (AR) in skeletal muscle is not well established. TEI‐SARM2, a novel select
Externí odkaz:
https://doaj.org/article/e7077ee7dbbd44928f4a9127b53818ec
Autor:
Kyohei Horie, Takashi Misawa, Midori Takimoto-Kamimura, Genichiro Tsuji, Eiji Ochiai, Shinji Kakuda, Takeo Takahashi, Kenichiro Takagi, Masaaki Kurihara, Yosuke Demizu
Publikováno v:
Bioorganicmedicinal chemistry. 26(23-24)
Non-secosteroidal VDR ligands without any assymmetric carbon were designed and synthesized based on the structure of the previously reported non-secosteroidal VDR agonist LG190178. The VDR-agonistic activity of all synthesized compounds was evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eee8314c042eed9a4a6e212974c71d4
https://pubmed.ncbi.nlm.nih.gov/30446437
https://pubmed.ncbi.nlm.nih.gov/30446437
Autor:
G. Satyanarayana Reddy, Daisuke Sawada, Masashi Takano, Miyu Nishikawa, Tai C. Chen, Kaori Yasuda, Kyohei Horie, Atsushi Kittaka, Ken Ichiro Takagi, Akiko Takeuchi, Toshiyuki Sakaki
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 148:34-37
Three different A-ring perhydroxylated trihydroxyvitamin D3 metabolites were synthesized from their appropriate A-ring precursors and CD-ring for their potential therapeutic applications. We first chemically synthesized 1α,2α,25-trihydroxyvitamin D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94212d0251e0003650271e2eaf691521
https://doi.org/10.1016/j.jsbmb.2014.09.021
https://doi.org/10.1016/j.jsbmb.2014.09.021
Autor:
Yosuke Demizu, Takeo Takahashi, Kenichiro Takagi, Fumiya Kaneko, Masaaki Kurihara, Midori Takimoto-Kamimura, Haruhiro Okuda, Shinji Kakuda, Yukiko Sato, Kyohei Horie, Eiji Ochiai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6104-6107
We designed and synthesized nonsecosteroidal vitamin D receptor (VDR) ligands that formed H-bonds with six amino acid residues (Tyr143, Ser233, Arg270, Ser274, His301 and His393) of the VDR ligand-binding domain. The ligand YR335 exhibited potent tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad27bdb572ed18a8d8519a4c4a96c66
https://doi.org/10.1016/j.bmcl.2011.08.047
https://doi.org/10.1016/j.bmcl.2011.08.047
Autor:
Masashi Takano, Hiroshi Saito, Seiichi Ishizuka, Nozomi Saito, Eiji Ochiai, Atsushi Kittaka, Shinji Kakuda, Kanako Shindo, Kyohei Horie, Midori Takimoto-Kamimura, Ken Ichiro Takagi, Go Kumagai, Daisuke Sawada, Kazuya Takenouchi
Publikováno v:
Organic Letters. 13:2852-2855
C15-Substituted 1α,25-dihydroxyvitamin D(3) analogs were synthesized for the first time to investigate the effects of the modified CD-ring on biological activity concerning the agonistic positioning of helix-3 and helix-12 of the vitamin D receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f988d030c8cebf6797d3750a5c8e6a
https://doi.org/10.1021/ol200828s
https://doi.org/10.1021/ol200828s
Autor:
Nobuaki Orihara, Akira Kudo, Hiroyuki Takeda, Yoshiyuki Imai, Davin H. E. Setiamarga, Kenta Hibiya, Sae Sakaguchi, Kiyoshi Naruse, Sayaka Konno, Tomoko Jindo, Shin-ichi Higashijima, Takanori Narita, Satoshi Ohisa, Akimitsu Miyake, Kyohei Horie, Daisuke Kobayashi
Publikováno v:
Development, Growth & Differentiation. 50:703-716
The medaka fish (Oryzias latipes) is an emerging model organism for which a variety of unique developmental mutants have now been generated. Our recent mutagenesis screening of the medaka isolated a unique mutant that develops a fatty liver at larval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1e261ea45332200c878c18a98a9926b
https://doi.org/10.1111/j.1440-169x.2008.01068.x
https://doi.org/10.1111/j.1440-169x.2008.01068.x
Autor:
Miki Matsuo, Asami Hasegawa, Masashi Takano, Hiroshi Saito, Shinji Kakuda, Kenichiro Takagi, Eiji Ochiai, Kyohei Horie, Midori Takimoto-Kamimura, Kazuya Takenouchi, et al. et al.
Publikováno v:
ChemInform. 46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7ecf9954ce7da3ce36bfe10a3d6da61
https://doi.org/10.1002/chin.201509332
https://doi.org/10.1002/chin.201509332
Autor:
Hiroshi Saito, Masashi Takano, Midori Takimoto-Kamimura, Kazuya Takenouchi, Miki Matsuo, Asami Hasegawa, Atsushi Kittaka, Kenichiro Takagi, Kyohei Horie, Eiji Ochiai, Daisuke Sawada, Shinji Kakuda
Publikováno v:
The Journal of steroid biochemistry and molecular biology.
X-ray cocrystallographic studies of the human vitamin D receptor (hVDR)-[2α-(3-hydroxypropyl)-1α,25-dihydroxyvitamin D3 (O1C3)] complex showed that the terminal hydroxy group of the 2α-functional group of O1C3 formed a hydrogen bond with Arg274 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c670cab326e4cf07d78856fce21e8868
https://pubmed.ncbi.nlm.nih.gov/24036313
https://pubmed.ncbi.nlm.nih.gov/24036313
Autor:
Masashi Takano, Yoshifumi Harada, Miki Matsuo, Kazuya Takenouchi, Daisuke Sawada, Asami Hasegawa, Atsushi Kittaka, Hiroshi Saito, Takayuki Chida, Kyohei Horie, Midori Takimoto-Kamimura, Shinji Kakuda, Eiji Ochiai, Ken Ichiro Takagi
Publikováno v:
ACS medicinal chemistry letters. 4(7)
2α-Heteroarylethyl-1α,25-dihydroxyvitamin D3 analogues, which were designed to form a hydrogen bond between Arg274 of human vitamin D receptor (hVDR) and a nitrogen atom of the heteroaromatic ring at the 2α-position, were synthesized. Among them,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b228a65114323573538317797f5ac90
https://pubmed.ncbi.nlm.nih.gov/24900728
https://pubmed.ncbi.nlm.nih.gov/24900728
Autor:
Yoshifumi Harada, Shinji Kakuda, Hiroshi Saito, Eiji Ochiai, Atsushi Kittaka, Takayuki Chida, Kazuya Takenouchi, Kyohei Horie, Kenichiro Takagi, Midori Takimoto-Kamimura
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 136
Up to the present, numerous vitamin D derivatives have been synthesized, but most of them have straight side chains, and there are few publications described about in vitro and in vivo evaluations on bone by vitamin D derivatives. In our previous pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfb7658bec924afedc2ceae5f7fdde6
https://pubmed.ncbi.nlm.nih.gov/23416104
https://pubmed.ncbi.nlm.nih.gov/23416104