Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kynurenine aminotransferase activity"'
Autor:
Ananda Staats Pires, Benjamin Heng, Vanessa X. Tan, Alexandra Latini, Marc A. Russo, Danielle M. Santarelli, Dominic Bailey, Katie Wynne, Jayden A. O’Brien, Gilles J. Guillemin, Paul J. Austin
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience
Frontiers in Neuroscience
Neuropathic pain is a common complication of diabetes with high morbidity and poor treatment outcomes. Accumulating evidence suggests the immune system is involved in the development of diabetic neuropathy, whilst neuro-immune interactions involving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f8c437c06efa1c0ef9041a77e9ac9f
https://www.frontiersin.org/article/10.3389/fnins.2020.00890/full
https://www.frontiersin.org/article/10.3389/fnins.2020.00890/full
Autor:
Artur Wnorowski, Izabela Zakrocka, Katarzyna M. Targowska-Duda, Krzysztof Jóźwiak, Wojciech Załuska, Tomasz Kocki, Waldemar A. Turski
Publikováno v:
Nephrology Dialysis Transplantation. 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1d8690bdd98f2fc64d7b1295d41fbf0
https://doi.org/10.1093/ndt/gfz106.fp026
https://doi.org/10.1093/ndt/gfz106.fp026
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific Reports
Scientific Reports
Kynurenic acid (KA) is a tryptophan (Trp) metabolite that is synthesised in a branch of kynurenine (KYN) pathway. KYN aminotransferase (KAT) catalyses deamination of KYN, yielding KA. Although KA synthesis is evolutionarily conserved from bacteria to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1fec21e9b3fd816abbd558f0d07ede
https://doi.org/10.1038/s41598-017-12392-6
https://doi.org/10.1038/s41598-017-12392-6
Autor:
Nicholas Stoy, Trevor W. Stone, J. Christofides, C. M. Forrest, G. M. Mackay, M. Egerton, L. G. Darlington
Publikováno v:
Journal of Neurochemistry. 93:611-623
Abnormalities in the kynurenine pathway may play a role in Huntington's disease (HD). In this study, tryptophan depletion and loading were used to investigate changes in blood kynurenine pathway metabolites, as well as markers of inflammation and oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59f7d9f413aefe7379a32b8479e2912
https://doi.org/10.1111/j.1471-4159.2005.03070.x
https://doi.org/10.1111/j.1471-4159.2005.03070.x
Publikováno v:
Journal of Neurochemistry. 65:2217-2226
The metabolism of L-tryptophan to the neuro-active kynurenine pathway metabolites, L-kynurenine, kynurenate and quinolinate, and the effects of two inhibitors of quinolinate synthesis (6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate) were inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a14111cf0fbf73bf36365c8d1e83ebb
https://doi.org/10.1046/j.1471-4159.1995.65052217.x
https://doi.org/10.1046/j.1471-4159.1995.65052217.x
Publikováno v:
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 120:139-143
Xanthurenic acid, the product of the enzyme kynurenine aminotransferase, has been suggested to have significant moult inhibiting action in crustaceans. We investigated kynurenine aminotransferase activity and its distribution in the prawn, Penaeus mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34ca25e544fc1cd0650c6b12655820a4
https://doi.org/10.1016/s0305-0491(98)10002-0
https://doi.org/10.1016/s0305-0491(98)10002-0
A recent study--comparing those with depression, somatization, comorbid depression+somatization, and controls--showed specific changes in the tryptophan catabolite (TRYCAT) pathway in somatization, specifically lowered tryptophan and kynurenic acid,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beba887040428539e72bc2ea6aefedc9
https://doi.org/10.1016/b978-0-12-398314-5.00002-7
https://doi.org/10.1016/b978-0-12-398314-5.00002-7
Publikováno v:
Journal of Biological Chemistry. 268:15496-15503
Mechanisms for increased levels of quinolinic acid (QUIN) following systemic immune stimulation were investigated. In gerbils, systemic administration of pokeweed mitogen (PWM) increased plasma and cerebrospinal fluid QUIN levels, while plasma kynure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c335045ce53e55fe77986edf6a8ecbb
https://doi.org/10.1016/s0021-9258(18)82284-0
https://doi.org/10.1016/s0021-9258(18)82284-0
Publikováno v:
Journal of Neurochemistry. 60:180-192
Delayed increases in the levels of an endogenous N-methyl-D-aspartate receptor agonist, quinolinic acid (QUIN), have been demonstrated following transient ischemia in the gerbil and were postulated to be secondary to induction of indoleamine-2,3-diox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8b48faf1a4876a5a333acc2f4af598
https://doi.org/10.1111/j.1471-4159.1993.tb05836.x
https://doi.org/10.1111/j.1471-4159.1993.tb05836.x
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 60:874-876
It is known that the anti-tuberculosis drug, isonicotinic acid hydrazide (INH), causes pellagra, a niacin deficiency syndrome, and peripheral neuritis in humans. We investigated the effects of INH on the metabolism of tryptophan to niacin in rats fed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cac1fef83d405467a6af1ec9460109
https://doi.org/10.1271/bbb.60.874
https://doi.org/10.1271/bbb.60.874