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Akademický článek

Metabolic Features of Increased Gut Permeability, Inflammation, and Altered Energy Metabolism Distinguish Agricultural Workers at Risk for Mesoamerican Nephropathy

Autor: Nathan H. Raines, Dominick A. Leone, Cristina O’Callaghan-Gordo, Oriana Ramirez-Rubio, Juan José Amador, Damaris Lopez Pilarte, Iris S. Delgado, Jessica H. Leibler, Nieves Embade, Rubén Gil-Redondo, Chiara Bruzzone, Maider Bizkarguenaga, Madeleine K. Scammell, Samir M. Parikh, Oscar Millet, Daniel R. Brooks, David J. Friedman

Publikováno v: Metabolites, Vol 13, Iss 3, p 325 (2023)

Mesoamerican nephropathy (MeN) is a form of chronic kidney disease found predominantly in young men in Mesoamerica. Strenuous agricultural labor is a consistent risk factor for MeN, but the pathophysiologic mechanism leading to disease is poorly unde

Externí odkaz: https://doaj.org/article/354e1c3725e24c41ba2f6844276d48e9

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Akademický článek

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Akademický článek

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Autor: Lilian Fernandes Silva, Teemu Kuulasmaa, Markku Laakso, Jagadish Vangipurapu, Ulf Smith

Publikováno v: Diabetes Care. 43:1319-1325

OBJECTIVE Recent studies have highlighted the significance of the microbiome in human health and disease. Changes in the metabolites produced by microbiota have been implicated in several diseases. Our objective was to identify microbiome metabolites

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784c5c876704e6b9545b75553f511158
https://doi.org/10.2337/dc19-2533

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Does kynurenic acid act on nicotinic receptors? An assessment of the evidence

Autor: Trevor W. Stone

Publikováno v: Journal of Neurochemistry

As a major metabolite of kynurenine in the oxidative metabolism of tryptophan, kynurenic acid is of considerable biological and clinical importance as an endogenous antagonist of glutamate in the central nervous system. It is most active as an antago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1854ea37be7dad2bdb1cab0bd32075b3
https://doi.org/10.1111/jnc.14907

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ASIC3-dependent metabolomics profiling of serum and urine in a mouse model of fibromyalgia

Autor: Yen-Ming Chao, Wei-Chi Ku, Yun-Lian Lin, Cheng-Han Lee, Wei-Hsiang Hsu, Ching-Hua Kuo, Chih-Cheng Chen

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports

Fibromyalgia (FM) is characterized by chronic widespread pain. The pathogenesis of FM remains unclear. No specific biomarkers are available. Animal models of FM may provide an opportunity to explore potential biomarkers in a relative homogenous disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b474712871dce8ae11ebf5d32d0c15
http://link.springer.com/article/10.1038/s41598-019-48315-w

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Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies

Publikováno v: Gut
Gut, vol 71, iss 6

ObjectiveTryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6b6ac0583a4e063fc42bf140e09355
https://europepmc.org/articles/PMC8697256/

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Monosodium Glutamate Induces Changes in Hepatic and Renal Metabolic Profiles and Gut Microbiome of Wistar Rats

Autor: Amod Sharma, Jutarop Phetcharaburanin, Jarus Joonhuathon, Ubon Cha'on, Piyanard Boonnate, Carlo Selmi, Raynoo Thanan, Atit Silsirivanit, Jia V. Li, Kanokwan Nahok, Sirirat Anutrakulchai

Publikováno v: Nutrients
Volume 13
Issue 6
Nutrients, Vol 13, Iss 1865, p 1865 (2021)

The short- and long-term consumption of monosodium glutamate (MSG) increases urinary pH but the effects on the metabolic pathways in the liver, kidney and the gut microbiota remain unknown. To address this issue, we investigated adult male Wistar rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7e55c0bcb5cf39d58e2cd7767700bc

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