Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kymberly, Levine"'
Autor:
Veronica Jové, Heather Wheeler, Chiachin Wilson Lee, David R. Healy, Kymberly Levine, Erik C. Ralph, Masaya Yamaguchi, Ziyue Karen Jiang, Edward Cabral, Yingrong Xu, Jeffrey Stock, Bing Yang, Anand Giddabasappa, Paula Loria, Agustin Casimiro-Garcia, Benedikt M. Kessler, Adán Pinto-Fernández, Véronique Frattini, Paul D. Wes, Feng Wang
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109593- (2024)
Summary: Precise regulation of Type I interferon signaling is crucial for combating infection and cancer while avoiding autoimmunity. Type I interferon signaling is negatively regulated by USP18. USP18 cleaves ISG15, an interferon-induced ubiquitin-l
Externí odkaz:
https://doaj.org/article/9891ba2dcc8a4ca097d1e8e73e654873
Autor:
Feng Wang, Bing Yang, Benedikt M Kessler, Veronica Jove, Heather Wheeler, Chiachin Wilson Lee, David R Healy, Kymberly Levine, Erik C Ralph, Anand Giddabasappa, Paula Loria, Masaya Yamaguchi, Agustin Casimiro-Garcia, Adan Pinto-Fernandez, Veronique Frattini, Paul Wes
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/f788494f35044f218c66952866b4b29d
Autor:
Veronica Jové, Heather Wheeler, Chiachin Wilson Lee, David R. Healy, Kymberly Levine, Erik C. Ralph, Bing Yang, Anand Giddabasappa, Paula Loria, Masaya Yamaguchi, Agustin Casimiro-Garcia, Benedikt M. Kessler, Adán Pinto-Fernández, Véronique Frattini, Paul D. Wes, Feng Wang
Precise temporal regulation of Type I interferon signaling is imperative to effectively fight infections and cancerous cells without triggering autoimmunity. The key negative regulator of Type I interferon signaling is ubiquitin-specific protease 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e620b6a1b8a7c1fb20f83ca5907eeee9
https://doi.org/10.1101/2023.03.23.533924
https://doi.org/10.1101/2023.03.23.533924
Autor:
Luping Qiu, Kymberly Levine, Ketan S Gajiwala, Ciarán N Cronin, Asako Nagata, Eric Johnson, Michelle Kraus, John Tatlock, Robert Kania, Timothy Foley, Shaoxian Sun
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198374 (2018)
Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as an oncogene that promotes tumor cell proliferation, migration and evasion. Both kinase-dependent and -independent functions of PTK6 in driving tumor g
Externí odkaz:
https://doaj.org/article/14826eba87d1454caa8322f0b783ae9f
Autor:
Rachel Roach, Joseph Sergi, Mark Horn, Mike Favis, Jeanne Sue Magram, Victoria Markiewicz, William B. Snyder, Kymberly Levine, Jennifer Colangelo, Jean Chamoun, Moosa Mohammadi, Jacqueline Vekich, Dikran Aivazian, Edwin Berryman, William J. Reagan, Cedo M. Bagi, Kristen Johnson, Anthony J. Coyle, Brian Robert Miller, Xianjun Cao, Thomas P. Brown
Publikováno v:
Journal of Bone and Mineral Research. 32:2062-2073
Fibroblast growth factor 23 (FGF23) is the causative factor of X-linked hypophosphatemia (XLH), a genetic disorder effecting 1:20,000 that is characterized by excessive phosphate excretion, elevated FGF23 levels and a rickets/osteomalacia phenotype.
Autor:
Robert Steven Kania, Eric Johnson, Tatlock John H, Luping Qiu, Timothy L. Foley, Shaoxian Sun, Kymberly Levine, Ketan S. Gajiwala, Ciarán N. Cronin, Michelle Kraus, Asako Nagata
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0198374 (2018)
PLoS ONE, Vol 13, Iss 6, p e0198374 (2018)
Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as an oncogene that promotes tumor cell proliferation, migration and evasion. Both kinase-dependent and -independent functions of PTK6 in driving tumor g
Autor:
Kristen, Johnson, Kymberly, Levine, Joseph, Sergi, Jean, Chamoun, Rachel, Roach, Jacqueline, Vekich, Mike, Favis, Mark, Horn, Xianjun, Cao, Brian, Miller, William, Snyder, Dikran, Aivazian, William, Reagan, Edwin, Berryman, Jennifer, Colangelo, Victoria, Markiewicz, Cedo M, Bagi, Thomas P, Brown, Anthony, Coyle, Moosa, Mohammadi, Jeanne, Magram
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 32(10)
Fibroblast growth factor 23 (FGF23) is the causative factor of X-linked hypophosphatemia (XLH), a genetic disorder effecting 1:20,000 that is characterized by excessive phosphate excretion, elevated FGF23 levels and a rickets/osteomalacia phenotype.
Autor:
Dale Porter, Lawrence Blas Perez, Kymberly Levine, Walter Michael, Catherine Fiorilla, Michael Dore, Raviraj Kulathila, Kara Herlihy, Michael Scott Visser, Simon van der Plas, Dipietro Lucian, Michael A Mcewan, Clayton Springer, Xiaoling Xie, Francois Lenoir, Karen Miller-Moslin, Madelene Y. Hoe, B. Barry Touré, Naeem Yusuff, Rajesh Karki, John Sullivan, Carol Joud
Overexpression of the antiapoptotic members of the Bcl-2 family of proteins is commonly associated with cancer cell survival and resistance to chemotherapeutics. Here, we describe the structure-based optimization of a series of N-heteroaryl sulfonami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175a4571a176ef8fb09f300f0c02b1fa
https://europepmc.org/articles/PMC4027142/
https://europepmc.org/articles/PMC4027142/
Autor:
Kymberly Levine, Elena Jacobson, Jingxin Zhang, Jerry Donovan, David E. Fisher, Dale Porter, Kevin T. McHenry, Leigh Zawel
Publikováno v:
Cancer Research. 71:LB-19
Toll-like Receptor-3 (TLR-3), a pattern recognition receptor family member, has been shown to activate immune system pathways; however, it has also been shown to induce apoptosis in certain cancer cells. Combination of the synthetic TLR-3 ligand, pol
Autor:
Rebecca Mosher, Christopher Sean Straub, He Feng, Megan Yao, Yang Fan, Colleen Conway, Julian Chen, Dan He, Brant Firestone, John Sullivan, Stephen Fawell, Frank Stegmeier, Kymberly Levine, Dale Porter, Joanna Slisz, Tim Ramsey, Pham Ly Luu, Hui Gao, John Monahan, Michael Morrissey, Leigh Zawel, Guizhi Yang
Publikováno v:
Cancer Research. 70:138-138
Inhibitor of Apoptosis Proteins (IAP) proteins negatively regulate cell death through a variety of mechanisms. The prototypical IAP family member XIAP binds and inhibits the catalytic activity of caspases 3/7 and caspase 9 via the BIR2-linker region