Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Kylie M Wagstaff"'
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Background The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in glycolysis. Here, we show that expression of alpha-enolase correlates with subcellular loc
Externí odkaz:
https://doaj.org/article/ebc6ef5325644d92b45ceca6d5fe45d8
Autor:
Lindsay Lundberg, Chelsea Pinkham, Cynthia de la Fuente, Ashwini Brahms, Nazly Shafagati, Kylie M Wagstaff, David A Jans, Sharon Tamir, Kylene Kehn-Hall
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 11, p e0005122 (2016)
The capsid structural protein of the New World alphavirus, Venezuelan equine encephalitis virus (VEEV), interacts with the host nuclear transport proteins importin α/β1 and CRM1. Novel selective inhibitor of nuclear export (SINE) compounds, KPT-185
Externí odkaz:
https://doaj.org/article/6ee7079ab4dd440c80b3aad825d36fab
Autor:
Caitlin L Rowe, Kylie M Wagstaff, Sibil Oksayan, Dominic J Glover, David A Jans, Gregory W Moseley
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150477 (2016)
Rabies virus P-protein is expressed as five isoforms (P1-P5) which undergo nucleocytoplasmic trafficking important to roles in immune evasion. Although nuclear import of P3 is known to be mediated by an importin (IMP)-recognised nuclear localization
Externí odkaz:
https://doaj.org/article/48ad38990119400d922b6cdb47952645
Autor:
Alejandra Vásquez-Limeta, Kylie M Wagstaff, Arturo Ortega, Dorothy H Crouch, David A Jans, Bulmaro Cisneros
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90629 (2014)
The β-dystroglycan (β-DG) protein has the ability to target to multiple sites in eukaryotic cells, being a member of diverse protein assemblies including the transmembranal dystrophin-associated complex, and a nuclear envelope-localised complex tha
Externí odkaz:
https://doaj.org/article/7f8c2436cc1b4e2296f85a9f5ce616e9
Autor:
Hayley J Newton, Jaclyn S Pearson, Luminita Badea, Michelle Kelly, Mark Lucas, Gavan Holloway, Kylie M Wagstaff, Michelle A Dunstone, Joan Sloan, James C Whisstock, James B Kaper, Roy M Robins-Browne, David A Jans, Gad Frankel, Alan D Phillips, Barbara S Coulson, Elizabeth L Hartland
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000898 (2010)
Many bacterial pathogens utilize a type III secretion system to deliver multiple effector proteins into host cells. Here we found that the type III effectors, NleE from enteropathogenic E. coli (EPEC) and OspZ from Shigella, blocked translocation of
Externí odkaz:
https://doaj.org/article/db95da39b4bb43fb9bafe6e7de4ba46d
Autor:
Alexander J. Martin, David M. Shackleford, Susan A. Charman, Kylie M. Wagstaff, Christopher J. H. Porter, David A. Jans
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1974 (2023)
N-(4-hydroxyphenyl) retinamide (4-HPR, or fenretinide) has promising in vitro and in vivo antiviral activity against a range of flaviviruses and an established safety record, but there are challenges to its clinical use. This study evaluated the in v
Externí odkaz:
https://doaj.org/article/2a1e9a8fc4ec461b8d615f90a672e66c
Publikováno v:
Cells, Vol 12, Iss 2, p 279 (2023)
The cellular response to environmental stresses, such as heat and oxidative stress, is dependent on extensive trafficking of stress-signalling molecules between the cytoplasm and nucleus, which potentiates stress-activated signalling pathways, eventu
Externí odkaz:
https://doaj.org/article/a00367e302624244ae4f6959a9db25c5
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13899 (2022)
Signal-dependent transport into and out of the nucleus mediated by members of the importin (IMP) superfamily of nuclear transporters is critical to the eukaryotic function and a point of therapeutic intervention with the potential to limit disease pr
Externí odkaz:
https://doaj.org/article/525be17ec82c4935b8123417d13bf821
Publikováno v:
Nanoscale Advances. 5:2251-2260
In this work, sortase A enzyme was used to generate seamless unbranched biotinylated nanobodies for multivalent complex formation via (strept)avidin–biotin interaction, with important application in optical microscopy and virus inhibition.
Autor:
Hareth A. Al-Wassiti, David R. Thomas, Kylie M. Wagstaff, Stewart A. Fabb, David A. Jans, Angus P. Johnston, Colin W. Pouton
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3310 (2021)
Adenoviruses contain dsDNA covalently linked to a terminal protein (TP) at the 5′end. TP plays a pivotal role in replication and long-lasting infectivity. TP has been reported to contain a nuclear localisation signal (NLS) that facilitates its impo
Externí odkaz:
https://doaj.org/article/c7739f9e3f2b431e926f09d56df3146f