Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Kylie Deng"'
1
Akademický článek
Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ signalling to control glucose-dependent insulin secretion
Autor: Dillon Jevon, Kylie Deng, Nicole Hallahan, Krish Kumar, Jason Tong, Wan Jun Gan, Clara Tran, Marcela Bilek, Peter Thorn
Publikováno v: eLife, Vol 11 (2022)
A developing understanding suggests that spatial compartmentalisation in pancreatic β cells is critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cell subcellular imaging methods using the mouse organoty
Externí odkaz: https://doaj.org/article/20dc23e379ba40cab6b3df7b4494ac7e
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2
Akademický článek
Glucose-Dependent Insulin Secretion from β Cell Spheroids Is Enhanced by Embedding into Softer Alginate Hydrogels Functionalised with RGD Peptide
Autor: Md Lutful Amin, Kylie Deng, Hien A. Tran, Reena Singh, Jelena Rnjak-Kovacina, Peter Thorn
Publikováno v: Bioengineering, Vol 9, Iss 12, p 722 (2022)
Type 1 diabetes results from the loss of pancreatic β cells, reduced insulin secretion and dysregulated blood glucose levels. Replacement of these lost β cells with stem cell-derived β cells, and protecting these cells within macro-device implants
Externí odkaz: https://doaj.org/article/96c18964b5fa43efb687831f3123b5e1
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3
Akademický článek
Machine Learning Algorithms, Applied to Intact Islets of Langerhans, Demonstrate Significantly Enhanced Insulin Staining at the Capillary Interface of Human Pancreatic β Cells
Autor: Louise Cottle, Ian Gilroy, Kylie Deng, Thomas Loudovaris, Helen E. Thomas, Anthony J. Gill, Jaswinder S. Samra, Melkam A. Kebede, Jinman Kim, Peter Thorn
Publikováno v: Metabolites, Vol 11, Iss 6, p 363 (2021)
Pancreatic β cells secrete the hormone insulin into the bloodstream and are critical in the control of blood glucose concentrations. β cells are clustered in the micro-organs of the islets of Langerhans, which have a rich capillary network. Recent
Externí odkaz: https://doaj.org/article/4b694be37f45486b8bb8ca0d57b18f07
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4
Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ signalling to control glucose-dependent insulin secretion
Autor: Nicole Hallahan, Kylie Deng, Dillon Jevon, Krish Kumar, Jason Tong, Wan Jun Gan, Clara Tran, Marcela Bilek, Peter Thorn
Publikováno v: eLife. 11
A developing understanding suggests that spatial compartmentalisation in pancreatic β cells is critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cell subcellular imaging methods using the mouse organoty
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57d271efde692b7909f6a3fbd05dbdcd
https://doi.org/10.7554/elife.76262
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6
Presynaptic-like mechanisms and the control of insulin secretion in pancreatic β-cells
Autor: Kylie Deng, Peter Thorn
Publikováno v: Cell calcium. 104
Exocytotic release of hormones from endocrine cells must encompass mechanisms that direct the hormone into the blood stream. Increasing evidence indicates an intimate link between pancreatic β-cells and the capillary bed of islets of Langerhans in b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60b1b5905be6873feb3d6c8a32e8d05
https://pubmed.ncbi.nlm.nih.gov/35405569
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8
Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ channel function to control glucose dependent insulin secretion
Autor: Nicole Hallahan, Kylie Deng, Dillon Jevon, Krish Kumar, Jason Tong, Wan Jun Gan, Clara Tran, Marcela Bilek, Peter Thorn
A developing understanding suggests that spatial compartmentalisation of components the glucose stimulus-secretion pathway in pancreatic β cells are critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8708a5fa21c6d1b797666704845bcfe6
https://doi.org/10.1101/2021.12.21.473760
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9
Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca
Autor: Dillon, Jevon, Kylie, Deng, Nicole, Hallahan, Krish, Kumar, Jason, Tong, Wan Jun, Gan, Clara, Tran, Marcela, Bilek, Peter, Thorn
Publikováno v: eLife. 11
A developing understanding suggests that spatial compartmentalisation in pancreatic β cells is critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cell subcellular imaging methods using the mouse organoty
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c50138f4a4d09d815916a96d54f94553
https://pubmed.ncbi.nlm.nih.gov/35559734
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10
Machine Learning Algorithms, Applied to Intact Islets of Langerhans, Demonstrate Significantly Enhanced Insulin Staining at the Capillary Interface of Human Pancreatic β Cells
Autor: Thomas Loudovaris, Melkam A. Kebede, Helen E. Thomas, Anthony J. Gill, Kylie Deng, Peter Thorn, Jinman Kim, Ian Gilroy, Jaswinder S. Samra, Louise Cottle
Publikováno v: Metabolites
Volume 11
Issue 6
Metabolites, Vol 11, Iss 363, p 363 (2021)
Pancreatic β cells secrete the hormone insulin into the bloodstream and are critical in the control of blood glucose concentrations. β cells are clustered in the micro-organs of the islets of Langerhans, which have a rich capillary network. Recent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afb15709fddecdafa7a92dd8d275c8a
https://doi.org/10.3390/metabo11060363
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