Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kylie B R Belchamber"'
Autor:
Martin A Bewley, Kylie B R Belchamber, Kirandeep K Chana, Richard C Budd, Gavin Donaldson, Jadwiga A Wedzicha, Christopher E Brightling, Iain Kilty, Louise E Donnelly, Peter J Barnes, Dave Singh, Moira K B Whyte, David H Dockrell, COPDMAP
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163139 (2016)
Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Defects in macrophage phagocytosis of both bacteria and apoptotic cells contribute to the COPD phenotype. Small molecul
Externí odkaz:
https://doaj.org/article/93b4546360fc4a8381bc77a1fb98b2dd
Autor:
Rahul Y. Mahida, Aaron Scott, Dhruv Parekh, Sebastian T. Lugg, Kylie B. R. Belchamber, Rowan S. Hardy, Michael A. Matthay, Babu Naidu, David R. Thickett
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Background: Impaired alveolar macrophage (AM) efferocytosis may contribute to acute respiratory distress syndrome (ARDS) pathogenesis; however, studies are limited by the difficulty in obtaining primary AMs from patients with ARDS. Our objective was
Externí odkaz:
https://doaj.org/article/a3a3ec2d9b0147419230ca9db71984aa
Autor:
Kylie B. R. Belchamber, Onn S. Thein, Jon Hazeldine, Frances S. Grudzinska, Aduragbemi A. Faniyi, Michael J. Hughes, Alice E. Jasper, Kay Por Yip, Louise E. Crowley, Sebastian T. Lugg, Elizabeth Sapey, Dhruv Parekh, David R. Thickett, Aaron Scott
Publikováno v:
Cells, Vol 11, Iss 18, p 2901 (2022)
Rationale: Infection with the SARS-CoV2 virus is associated with elevated neutrophil counts. Evidence of neutrophil dysfunction in COVID-19 is based on transcriptomics or single functional assays. Cell functions are interwoven pathways, and understan
Externí odkaz:
https://doaj.org/article/6e499c61195847cd87688b285c0e40fd
Autor:
Kylie B. R. Belchamber, Michael J. Hughes, Daniella A. Spittle, Eloise M. Walker, Elizabeth Sapey
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Infection and inflammation of the lung results in the recruitment of non-resident immune cells, including neutrophils, eosinophils and monocytes. This swift response should ensure clearance of the threat and resolution of stimuli which drive inflamma
Externí odkaz:
https://doaj.org/article/c8f704487f25477aa91a86a4b6454d29
Publikováno v:
British Journal of Pharmacology. 179:1790-1807
Lung diseases disproportionately affect elderly individuals. The lungs form a unique environment: a highly elastic organ with gaseous exchange requiring the closest proximity of inhaled air containing harmful agents and the circulating blood. The lun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50036120545701bfc178f938eed40e40
https://doi.org/10.1111/bph.15759
https://doi.org/10.1111/bph.15759
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease. 15:3183-3192
Alpha-1 antitrypsin deficiency (AATD) is a genetic condition characterised by low circulating levels of alpha-1 antitrypsin (AAT), a serine proteinase inhibitor. The most common deficiency variants are the S and Z mutations, which cause the accumulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28d2d108702015f8d4fddb2a93c9e22f
https://doi.org/10.2147/copd.s276792
https://doi.org/10.2147/copd.s276792
Autor:
Katharine M. Lodge, Arlette Vassallo, Bin Liu, Merete Long, Zhen Tong, Paul R. Newby, Danya Agha-Jaffar, Koralia Paschalaki, Clara E. Green, Kylie B. R. Belchamber, Victoria C. Ridger, Robert A. Stockley, Elizabeth Sapey, Charlotte Summers, Andrew S. Cowburn, Edwin R. Chilvers, Wei Li, Alison M. Condliffe
Publikováno v:
American journal of respiratory and critical care medicine. 205(8)
Rationale: Patients with chronic obstructive pulmonary disease (COPD) experience excess cardiovascular morbidity and mortality, and exacerbations further increase the risk of such events. COPD is associated with persistent blood and airway neutrophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fd848c176ef31f32c61629c9f1bb85
https://pubmed.ncbi.nlm.nih.gov/35148486
https://pubmed.ncbi.nlm.nih.gov/35148486
Autor:
Michael J. Hughes, Frances Grudzinska, K. P. Yip, S. Thein, Alice E Jasper, J. Hazeldine, David R Thickett, Elizabeth Sapey, Aaron Scott, Kylie B. R. Belchamber, Dhruv Parekh
Publikováno v:
Understanding COVID-19 mechanisms.
RationalInfection with the SARS-CoV2 virus is associated with elevated neutrophil counts. Evidence of neutrophil dysfunction in COVID-19 is based predominantly on transcriptomics or single functional assays. Cell functions are interwoven pathways, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::617cf39a9ddf7885fad50905070b02fc
https://doi.org/10.1136/thorax-2021-btsabstracts.60
https://doi.org/10.1136/thorax-2021-btsabstracts.60
Autor:
Alice E Jasper, Kay Por Yip, Frances Grudzinska, David R Thickett, Kylie B. R. Belchamber, Aaron Scott, Dhruv Parekh, Elizabeth Sapey, Michael Hughes, Shaun Thein, Jon Hazeldine
Publikováno v:
Respiratory infections and bronchiectasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2363d54533b2bb4584d3351f7015114e
https://doi.org/10.1183/13993003.congress-2021.oa3974
https://doi.org/10.1183/13993003.congress-2021.oa3974
Autor:
Rowan Hardy, David R Thickett, Dhruv Parekh, Rahul Y Mahida, Michael A. Matthay, Aaron Scott, Babu Naidu, Kylie B. R. Belchamber, Sebastian T Lugg
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Frontiers in Medicine
Frontiers in Medicine
Background: Impaired alveolar macrophage (AM) efferocytosis may contribute to acute respiratory distress syndrome (ARDS) pathogenesis; however, studies are limited by the difficulty in obtaining primary AMs from patients with ARDS. Our objective was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cb8c0b7877a3cda1c93c58ddad06c0
https://www.frontiersin.org/articles/10.3389/fmed.2021.737859/full
https://www.frontiersin.org/articles/10.3389/fmed.2021.737859/full