Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kylie A. MacGregor"'
Autor:
Anna Mariana, Ngoc Chau, Ainslie Whiting, Kylie A. MacGregor, Phillip J. Robinson, Luke R. Odell, Adam McCluskey, Mohammed K. Abdel-Hamid
Publikováno v:
Organic & Biomolecular Chemistry. 13:8016-8028
Fragment-based in silico screening against dynamin I (dynI) GTPase activity identified the 1,8-naphthalimide framework as a potential scaffold for the design of new inhibitors targeting the GTP binding pocket of dynI. Structure-based design, synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36e48312f585d23e6a977d62a556ee4
https://doi.org/10.1039/c5ob00751h
https://doi.org/10.1039/c5ob00751h
Autor:
Mark J. Robertson, Wiebke Stahlschmidt, Kylie A. MacGregor, Phillip J. Robinson, Lisa von Kleist, Adam McCluskey, Ngoc Chau, Kelly A. Young, Ainslie Whiting, Volker Haucke
Publikováno v:
Journal of Medicinal Chemistry. 57:131-143
We reported the first small molecule inhibitors of the interaction between the clathrin N-terminal domain (TD) and endocyctic accessory proteins (i.e., clathrin inhibition1). Initial screening of a ∼17 000 small molecule ChemBioNet library identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb74178a5c8a0830d8e736f780bf365
https://doi.org/10.1021/jm4015263
https://doi.org/10.1021/jm4015263
Autor:
Adam McCluskey, Kylie A. MacGregor
Publikováno v:
Tetrahedron Letters. 52:767-769
The synthesis of N-substituted-1,8-naphthalimides is accelerated in the presence of the room temperature ionic liquid [BMIM][NO 3 ]. Reaction times are reduced from 18 h in volatile organic compounds (VOCs) (PhCH 3 , EtOH and THF) to 20 min in the io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8ef505d2348070eb6142c57faebc15
https://doi.org/10.1016/j.tetlet.2010.12.015
https://doi.org/10.1016/j.tetlet.2010.12.015
Autor:
Mohammed K. Abdel-Hamid, Adam McCluskey, Ainslie Whiting, Kylie A. MacGregor, Ngoc Chau, Phillip J. Robinson, Luke R. Odell
Publikováno v:
European journal of medicinal chemistry. 85
Virtual screening of the ChemDiversity and ChemBridge compound databases against dynamin I (dynI) GTPase activity identified 2,5-bis-(benzylamino)-1,4-benzoquinone 1 as a 273 ± 106 μM inhibitor. In silico lead optimization and focused library-led s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a88da476e954cb73fdd33b62283d561
https://pubmed.ncbi.nlm.nih.gov/25084145
https://pubmed.ncbi.nlm.nih.gov/25084145
Autor:
Kylie A. MacGregor, Adam McCluskey
Publikováno v:
ChemInform. 42
Replacement of organic volatile compounds by the ionic liquid results in significant acceleration of the reaction of anhydrides (I) with functionalized amines (16 h versus 20 min).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1ebd030e477c26a60d2357adedbe9f4
https://doi.org/10.1002/chin.201118085
https://doi.org/10.1002/chin.201118085
Autor:
Christopher P. Gordon, Mark J. Robertson, Adam McCluskey, Jana Guenther, Anthony D. Wright, Kylie A. MacGregor
Publikováno v:
Organicbiomolecular chemistry. 9(2)
In an investigation into their potential ecological role(s), a group of mainly diterpene isonitriles, nine in total, isolated from the tropical marine sponge Cymbastela hooperi, and the sesquiterpene axisonitrile-3, isolated from the tropical marine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e9bcf7d7cbc33cb417d87ce608284e
https://pubmed.ncbi.nlm.nih.gov/21042642
https://pubmed.ncbi.nlm.nih.gov/21042642
Publikováno v:
Planta Medica. 74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37402924ede95ffd2743ae5696b92a2d
https://doi.org/10.1055/s-0028-1083978
https://doi.org/10.1055/s-0028-1083978
Autor:
Kylie A. MacGregor, Jennette A. Sakoff, Wolfram Saenger, Ngoc Chau, Oleg Shupliakov, Mark J. Robertson, Arndt Pechstein, Adam McCluskey, Dmytro Puchkov, Volker Haucke, Haydar Bulut, Megan Chircop, Lisa von Kleist, Jens Peter von Kries, Hans-Georg Kräusslich, Kira Gromova, Phillip J. Robinson, Nikolay Tomilin, Wiebke Stahlschmidt
Publikováno v:
Cell. (3):471-484
SummaryClathrin-mediated endocytosis (CME) regulates many cell physiological processes such as the internalization of growth factors and receptors, entry of pathogens, and synaptic transmission. Within the endocytic network, clathrin functions as a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72f701595bb16f0785e1bb0d93e5c6b