Western diet regulates immune status and the response to LPS-driven sepsis independent of diet-associated microbiome

Autor: Kerriann M. Casey, Andrew J. Hryckowian, Kyler A. Lugo, Marta Andres-Terre, Justin L. Sonnenburg, Brooke A. Napier, Denise M. Monack, Liliana M. Massis, Steven K. Higginbottom, David Schneider, Katherine Cumnock, Bereketeab Haileselassie

Publikováno v: Proceedings of the National Academy of Sciences. 116:3688-3694

Sepsis is a deleterious immune response to infection that leads to organ failure and is the 11th most common cause of death worldwide. Despite plaguing humanity for thousands of years, the host factors that regulate this immunological response and su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc68181a26052c70d9236aa936c5ab47
https://doi.org/10.1073/pnas.1814273116

Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection

Autor: Sophie Helaine, Jose G. Vilches-Moure, Meagan Hamblin, Denise M. Monack, Teresa L. M. Thurston, Amanda R. Jacobson, Kyler A. Lugo, Susan M. Brewer, Trung H.M. Pham, Liliana M. Massis, Jared Honeycutt

Publikováno v: 67.E5

Many intracellular bacteria can establish chronic infection and persist in tissues within granulomas composed of macrophages. Granuloma macrophages exhibit heterogeneous polarization states, or phenotypes, that may be functionally distinct. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1ba8fb25df24a748fb5a14dd7cafc4
https://doi.org/10.1016/j.chom.2019.11.011

A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns

Autor: Kiarash Shamardani, April E. Price, Jacques Deguine, Allison W. Roberts, Bettina L. Lee, Kyler A. Lugo, Gregory M. Barton

Publikováno v: Immunity, vol 49, iss 3

Summary Signaling by Toll-like receptors (TLRs) on intestinal epithelial cells (IECs) is critical for intestinal homeostasis. To visualize epithelial expression of individual TLRs in vivo, we generated five strains of reporter mice. These mice reveal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a76e7837cc0e09b1d6e6d258fbfef94
https://pubmed.ncbi.nlm.nih.gov/30231979

Pseudogenization of the Secreted Effector Gene sseI Confers Rapid Systemic Dissemination of S. Typhimurium ST313 within Migratory Dendritic Cells

Autor: Trung H.M. Pham, Kyler A. Lugo, Donna M. Bouley, Renée M. Tsolis, Jared Honeycutt, Denise M. Monack, Gregory T. Walker, Amanda Jacobson, Sarah Carden, Juliana Idoyaga

Publikováno v: Cell host & microbe, vol 21, iss 2
Carden, SE; Walker, GT; Honeycutt, J; Lugo, K; Pham, T; Jacobson, A; et al.(2017). Pseudogenization of the Secreted Effector Gene sseI Confers Rapid Systemic Dissemination of S. Typhimurium ST313 within Migratory Dendritic Cells. Cell Host and Microbe, 21(2), 182-194. doi: 10.1016/j.chom.2017.01.009. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/5r20820m

© 2017 Elsevier Inc. Genome degradation correlates with host adaptation and systemic disease in Salmonella. Most lineages of the S. enterica subspecies Typhimurium cause gastroenteritis in humans; however, the recently emerged ST313 lineage II patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1f015a6ff0c874181a8bbd88011ae7
https://pubmed.ncbi.nlm.nih.gov/28239150

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life

Autor: Meghan A. Koch, Lieselotte S. M. Kreuk, Gabrielle L. Reiner, William B. Ludington, Gregory M. Barton, Eduard Ansaldo, Kyler A. Lugo, Thaddeus D. Seher, Alison G. Stanbery

Publikováno v: Cell, vol 165, iss 4

To maintain a symbiotic relationship between the host and its resident intestinal microbiota, appropriate mucosal Tcell responses to commensal antigens must be established. Mice acquire both IgG and IgA maternally; the former has primarily been impli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08698056f0d81d377611f9bee1a1e31b
https://escholarship.org/uc/item/7nq544pn