Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kylee E. Eblin"'
Publikováno v:
Toxicology and Applied Pharmacology. 241:202-209
Malignant transformation was demonstrated in UROtsa cells following 52-weeks of exposure to 50 nM monomethylarsonous acid (MMA{sup III}); the result was the malignantly transformed cell line, URO-MSC. URO-MSC cells were used to study the induction of
Autor:
Sean M. Wnek, Taylor J. Jensen, Bernard W. Futscher, Ryan J. Wozniak, Kylee E. Eblin, A. Jay Gandolfi
Publikováno v:
Toxicology and Applied Pharmacology. 235:39-46
Arsenic is a human carcinogen with exposure associated with cancer of the lung, skin, and bladder. Many potential mechanisms have been implicated as playing a role in the process of arsenical-induced malignancy including the perturbation of signaling
Autor:
Shawn M. Wnek, A.J. Gandolfi, Taylor J. Jensen, Bernard W. Futscher, Kylee E. Eblin, S.E. Buffington
Publikováno v:
Toxicology. 255:107-114
UROtsa cells exposed to 50 nM monomethylarsonous acid [MMA(III)] for 52 wk (MSC52) achieved hyperproliferation, anchorage independent growth, and enhanced tumorgenicity. MMA(III) has been shown to induce reactive oxygen species (ROS), which can lead
Publikováno v:
Toxicology. 248:67-76
Arsenical-induced carcinogenesis in human bladder has been established through epidemiological evidence, and UROtsa cells, a normal, immortalized cell culture model of human urothelium, have proven to be a good model for the bladder epithelium. This
Publikováno v:
Carcinogenesis. 29:1500-1508
Humans are exposed to arsenicals through many routes with the most common being in drinking water. Exposure to arsenic has been associated with an increase in the incidence of cancer of the skin, lung and bladder. Although the relationship between ex
Autor:
Bhumasamudram Jagadish, Eugene A. Mash, A. Jay Gandolfi, Kylee E. Eblin, Tiffany G. Bredfeldt
Publikováno v:
Toxicology and Applied Pharmacology. 216:69-79
Arsenic is a human bladder carcinogen. Arsenic is methylated to both monomethyl and dimethyl metabolites which have been detected in human urine. The trivalent methylated arsenicals are more toxic than inorganic arsenic. It is unknown if these trival
Arsenicals are known to induce ROS, which can lead to DNA damage, oxidative stress, and carcinogenesis. A human urothelial cell line, UROtsa, was used to study the effects of arsenicals on the human bladder. Arsenite [As(III)] and monomethylarsonous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dda31b15f5e8f964abc14cb089e2240
https://europepmc.org/articles/PMC2567114/
https://europepmc.org/articles/PMC2567114/
Arsenic is widely spread in our living environment and imposes a big challenge on human health worldwide. Arsenic damages biological systems through multiple mechanisms including the generation of reactive oxygen species. The transcription factor Nrf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091d78d365e3310049ef0607b0b5425d
https://europepmc.org/articles/PMC2610476/
https://europepmc.org/articles/PMC2610476/
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 95(2)
Previous studies have shown that human bladder cells (UROtsa), a target of arsenic-induced cancer, can biotransform arsenite to monomethylarsonous acid (MMA(III)), which is more cytotoxic and capable of transforming the UROtsa cells following long-te
Autor:
Serrine S. Lau, A.J. Gandolfi, Tiffany G. Bredfeldt, Martina E. Bowen, Kylee E. Eblin, Eugene A. Mash, Douglas W. Cromey
Publikováno v:
Toxicology and applied pharmacology. 217(1)
Arsenicals have commonly been seen to induce reactive oxygen species (ROS) which can lead to DNA damage and oxidative stress. At low levels, arsenicals still induce the formation of ROS, leading to DNA damage and protein alterations. UROtsa cells, an