Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kyle W. Muir"'
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2116-2126 (2016)
Sister chromatid cohesion is a fundamental prerequisite to faithful genome segregation. Cohesion is precisely regulated by accessory factors that modulate the stability with which the cohesin complex embraces chromosomes. One of these factors, Pds5,
Externí odkaz:
https://doaj.org/article/173d19a667874edcac0946409763af46
Autor:
Alberto García-Nieto, Amrita Patel, Yan Li, Roel Oldenkamp, Leonardo Feletto, Joshua J. Graham, Laureen Willems, Kyle W. Muir, Daniel Panne, Benjamin D. Rowland
Publikováno v:
Nature Structural & Molecular Biology.
In the early stages of mitosis, cohesin is released from chromosome arms but not from centromeres. The protection of centromeric cohesin by SGO1 maintains the sister chromatid cohesion that resists the pulling forces of microtubules until all chromos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f553f5db8360d98bda031e04e6945d
https://doi.org/10.1038/s41594-023-00968-y
https://doi.org/10.1038/s41594-023-00968-y
Publikováno v:
eLife, Vol 7 (2018)
The cohesin ring complex is required for numerous chromosomal transactions including sister chromatid cohesion, DNA damage repair and transcriptional regulation. How cohesin engages its chromatin substrate has remained an unresolved question. We show
Externí odkaz:
https://doaj.org/article/5cc5282028dc4d4ebbcaa3a2d43703b8
Autor:
Stanislau Yatskevich, Kyle W. Muir, Dom Bellini, Ziguo Zhang, Jing Yang, Thomas Tischer, Masa Predin, Tom Dendooven, Stephen H. McLaughlin, David Barford
Publikováno v:
Science
Accurate chromosome segregation, controlled by kinetochore-mediated chromatid attachments to the mitotic spindle, ensures the faithful inheritance of genetic information. Kinetochores assemble onto specialized CENP-A nucleosomes (CENP-ANuc) of centro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfa17cce3d9a4e2ac0ee6b6235a2755
https://europepmc.org/articles/PMC7612757/
https://europepmc.org/articles/PMC7612757/
Publikováno v:
Nature structural & molecular biology
Genome regulation requires control of chromosome organization by SMC–kleisin complexes. The cohesin complex contains the Smc1 and Smc3 subunits that associate with the kleisin Scc1 to form a ring-shaped complex that can topologically engage chromat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e0a8c8b778b17f098909bd13e97ccc
http://europepmc.org/articles/PMC7100847
http://europepmc.org/articles/PMC7100847
Autor:
Long-Fei Wu, Kasim Sader, Pablo Castro-Hartmann, Jan Löwe, Kyle W. Muir, Pu Qian, Dari Kimanius, Francesca Coscia, Kyle Dent, John D. Sutherland, Christopher J. Russo, M. J. Peet, David Barford, Katerina Naydenova, Ziguo Zhang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Significance While the current COVID-19 pandemic continues, the US Food and Drug Administration (FDA) has approved only one drug against the virus—remdesivir. It is a nucleotide analogue inhibitor of the SARS-CoV-2 RNA-dependent RNA polymerase; fav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e21905789c96124d65b476169d06d7
https://pubmed.ncbi.nlm.nih.gov/33526596
https://pubmed.ncbi.nlm.nih.gov/33526596
Autor:
Francesca Coscia, Kyle W. Muir, Kyle Dent, Katerina Naydenova, M. J. Peet, Ziguo Zhang, Long-Fei Wu, Pu Qian, Christopher J. Russo, John D. Sutherland, Jan Löwe, Pablo Castro-Hartmann, Dari Kimanius, Kasim Sader, David Barford
The RNA polymerase inhibitor, favipiravir, is currently in clinical trials as a treatment for infection with SARS-CoV-2, despite limited information about the molecular basis for its activity. Here we report the structure of favipiravir ribonucleosid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d78e6eb8467a3da2960d030509851603
https://doi.org/10.1101/2020.10.21.347690
https://doi.org/10.1101/2020.10.21.347690
Publikováno v:
eLife
eLife, Vol 7 (2018)
'eLife ', vol: 7, pages: e38356-1-e38356-14 (2018)
eLife, Vol 7 (2018)
'eLife ', vol: 7, pages: e38356-1-e38356-14 (2018)
The cohesin ring complex is required for numerous chromosomal transactions including sister chromatid cohesion, DNA damage repair and transcriptional regulation. How cohesin engages its chromatin substrate has remained an unresolved question. We show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e34ec59dbb96b126e5440c96df2156
https://doi.org/10.7554/elife.38356
https://doi.org/10.7554/elife.38356
Introduction Forkhead box (Fox) proteins belong to a superfamily of transcription factors that is characterized by a highly conserved “winged-helix” DNA-binding domain. Following the discovery of the first Fox transcription factor, FoxA, in Droso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac9360e53cc48b3315f7212349eda7a
https://doi.org/10.1017/cbo9781139046947.029
https://doi.org/10.1017/cbo9781139046947.029