Výsledky vyhledávání - "Kyle W, Cunningham"

Akademický článek

The ReInvigorate Study—phrenic nerve-to-diaphragm stimulation for weaning from mechanical ventilation: a protocol for a randomized pivotal clinical trial

Autor: Katie Schaaf, Christopher M. Mullin, Kyle W. Cunningham, Jonathan Eaton, Steven A. Conrad

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-8 (2024)

Abstract Background In the United States in 2017, there were an estimated 903,745 hospitalizations involving mechanical ventilation (MV). Complications from ventilation can result in longer hospital stays, increased risk of disability, and increased

Externí odkaz: https://doaj.org/article/f571e2e350d942a395d938f239e270d4

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Akademický článek

Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrata

Autor: Andrew N. Gale, Matthew W. Pavesic, Timothy J. Nickels, Zhuwei Xu, Brendan P. Cormack, Kyle W. Cunningham

Publikováno v: mSphere, Vol 8, Iss 4 (2023)

ABSTRACT Candida glabrata is a prominent opportunistic fungal pathogen of humans. The increasing incidence of C. glabrata infections is attributed to both innate and acquired resistance to antifungals. Previous studies suggest the transcription facto

Externí odkaz: https://doaj.org/article/ae302ae477f44a03bc00b99e2aeb1b53

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Akademický článek

Identification of Essential Genes and Fluconazole Susceptibility Genes in Candida glabrata by Profiling Hermes Transposon Insertions

Autor: Andrew N. Gale, Rima M. Sakhawala, Anton Levitan, Roded Sharan, Judith Berman, Winston Timp, Kyle W. Cunningham

Publikováno v: G3: Genes, Genomes, Genetics, Vol 10, Iss 10, Pp 3859-3870 (2020)

Externí odkaz: https://doaj.org/article/7a8952b884d4442c96ee94d5eff3e67f

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Akademický článek

Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide

Autor: Nathan A. Snyder, Adam Kim, Louis Kester, Andrew N. Gale, Christian Studer, Dominic Hoepfner, Silvio Roggo, Stephen B. Helliwell, Kyle W. Cunningham

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 3, Pp 829-840 (2019)

Gene knockout and knockdown strategies have been immensely successful probes of gene function, but small molecule inhibitors (SMIs) of gene products allow much greater time resolution and are particularly useful when the targets are essential for cel

Externí odkaz: https://doaj.org/article/3c656557bb5648078cf2ced79446adef

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Akademický článek

CaGdt1 plays a compensatory role for the calcium pump CaPmr1 in the regulation of calcium signaling and cell wall integrity signaling in Candida albicans

Autor: Linghuo Jiang, Junjun Wang, Faiza Asghar, Nathan Snyder, Kyle W. Cunningham

Publikováno v: Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-16 (2018)

Abstract Background Saccharomyces cerevisiae ScGdt1 and mammalian TMEM165 are two members of the UPF0016 membrane protein family that is likely to form a new group of Ca2+/H+ antiporter and/or a Mn2+ transporter in the Golgi apparatus. We have previo

Externí odkaz: https://doaj.org/article/a256fed6d38c4db1878853840c0767b8

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Akademický článek

H+ and Pi Byproducts of Glycosylation Affect Ca2+ Homeostasis and Are Retrieved from the Golgi Complex by Homologs of TMEM165 and XPR1

Autor: Nathan A. Snyder, Christopher P. Stefan, Camille T. Soroudi, Adam Kim, Carlos Evangelista, Kyle W. Cunningham

Publikováno v: G3: Genes, Genomes, Genetics, Vol 7, Iss 12, Pp 3913-3924 (2017)

Glycosylation reactions in the Golgi complex and the endoplasmic reticulum utilize nucleotide sugars as donors and produce inorganic phosphate (Pi) and acid (H+) as byproducts. Here we show that homologs of mammalian XPR1 and TMEM165 (termed Erd1 and

Externí odkaz: https://doaj.org/article/892216a29abd43f2a3e13a43633bbd9f

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