The RNA Helicase Ded1 from Yeast Is Associated with the Signal Recognition Particle and Is Regulated by SRP21

Autor: Hilal Yeter-Alat, Naïma Belgareh-Touzé, Agnès Le Saux, Emmeline Huvelle, Molka Mokdadi, Josette Banroques, N. Kyle Tanner

Publikováno v: Molecules, Vol 29, Iss 12, p 2944 (2024)

The DEAD-box RNA helicase Ded1 is an essential yeast protein involved in translation initiation that belongs to the DDX3 subfamily. The purified Ded1 protein is an ATP-dependent RNA-binding protein and an RNA-dependent ATPase, but it was previously f

Externí odkaz: https://doaj.org/article/39bf31f6e85d49b399b6110509da1389

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.

Autor: Emna Harigua-Souiai, Yosser Zina Abdelkrim, Imen Bassoumi-Jamoussi, Ons Zakraoui, Guillaume Bouvier, Khadija Essafi-Benkhadir, Josette Banroques, Nathan Desdouits, Hélène Munier-Lehmann, Mourad Barhoumi, N Kyle Tanner, Michael Nilges, Arnaud Blondel, Ikram Guizani

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006160 (2018)

Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on public health. The identification of novel drugs and targets constitutes a research priority. For that purpose we used Leishmania infantum initiation factor 4

Externí odkaz: https://doaj.org/article/ebb7e2223ed14d3b805b46d2c9ede416

The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast

Autor: Hilal Yeter-Alat, Ikram Guizani, Yosser Zina Abdelkrim, Rafeh Oualha, Mourad Barhoumi, Emmeline Huvelle, N. Kyle Tanner, Molka Mokdadi, Josette Banroques

Publikováno v: Genes
Volume 12
Issue 2
Genes, MDPI, 2021, 12 (2), pp.212. ⟨10.3390/genes12020212⟩
Genes, Vol 12, Iss 212, p 212 (2021)

International audience; DEAD-box RNA helicases are ubiquitous proteins found in all kingdoms of life and that are associated with all processes involving RNA. Their central roles in biology make these proteins potential targets for therapeutic or pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622edaf6781a6147a1c335ce97b3d9eb

Known Inhibitors of RNA Helicases and Their Therapeutic Potential

Autor: Yosser Zina, Abdelkrim, Josette, Banroques, N, Kyle Tanner

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2209

RNA helicases are proteins found in all kingdoms of life, and they are associated with all processes involving RNA from transcription to decay. They use NTP binding and hydrolysis to unwind duplexes, to remodel RNA structures and protein-RNA complexe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::830f7b42eb6ef65f8565ce68acdad3ca
https://pubmed.ncbi.nlm.nih.gov/33201461

The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and ATP binding sites

Autor: N. Kyle Tanner, Mourad Barhoumi, Emna Harigua-Souiai, Arnaud Blondel, Josette Banroques, Yosser Zina Abdelkrim, Ikram Guizani

Publikováno v: Molecular and Biochemical Parasitology
Molecular and Biochemical Parasitology, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩
Molecular and Biochemical Parasitology, Elsevier, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩

International audience; The antifungal agent 6-aminocholestanol targets the production of ergosterol, which is the principle sterol in many fungi and protozoans; ergosterol serves many of the same roles as cholesterol in animals. We found that it als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1cab00f461442b882b9cc5b78e1a41
https://doi.org/10.1016/j.molbiopara.2018.10.001