Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kyle Tamshen"'
Autor:
Man Lu, Yue Wang, Ries J. Langley, Stephen M. F. Jamieson, Kyle Tamshen, Heather D. Maynard, Jo K. Perry
Publikováno v:
Bioconjugate Chemistry. 31:1651-1660
Growth hormone (GH) is a peptide hormone that mediates actions through binding to a cell surface GH receptor (GHR). The GHR antagonist, B2036, combines an amino acid substitution at 120 that confers GHR antagonist activity, with eight additional amin
Autor:
Kyle Tamshen, Heather D. Maynard, Yue Wang, Martin Middleditch, Stephen M. F. Jamieson, Ries J. Langley, Julia K. Harms, Jo K. Perry
Publikováno v:
Biomacromolecules. 22(2)
Growth hormone (GH) has been implicated in cancer progression andis a potential target for anticancer therapy. Currently, pegvisomant is the only GH receptor (GHR) antagonist approved for clinical use. Pegvisomant is a mutated GH molecule (B2036) whi
Publikováno v:
Bioconjug Chem
Regulation of human growth hormone (GH) signaling has important applications in the remediation of several diseases including acromegaly and cancer. Growth hormone receptor (GHR) antagonists currently provide the most effective means for suppression
Autor:
Yue, Wang, Ries J, Langley, Kyle, Tamshen, Stephen M, Jamieson, Man, Lu, Heather D, Maynard, Jo K, Perry
Publikováno v:
Bioconjugate chemistry. 31(6)
Growth hormone (GH) is a peptide hormone that mediates actions through binding to a cell surface GH receptor (GHR). The GHR antagonist, B2036, combines an amino acid substitution at 120 that confers GHR antagonist activity, with eight additional amin
Autor:
Stephen M. F. Jamieson, Yue Wang, Jo K. Perry, Ries J. Langley, Kyle Tamshen, Heather D. Maynard
Publikováno v:
Journal of the Endocrine Society
Growth hormone (GH) is a peptide hormone that mediates actions through binding to a cell surface GH receptor (GHR), activating key signalling pathways including the JAK/STAT pathway. Excess GH secretion leads to acromegaly and tumoral expression has
Autor:
Valerie A. Kickhoefer, Jonathan Fulcher, Leonard H. Rome, Alexander L. Wollenberg, Julie Elliott, Jan Mrazek, Otto O. Yang, Timothy J. Deming, Peter A. Anton, F. Javier Ibarrondo, Kyle Tamshen, Heather D. Maynard
Publikováno v:
Bioconjug Chem
Bioconjugate chemistry, vol 30, iss 8
Bioconjugate chemistry, vol 30, iss 8
"Vaults" are ubiquitously expressed endogenous ribonucleoprotein nanoparticles with potential utility for targeted drug delivery. Here, we show that recombinant human vault nanoparticles are readily engulfed by certain key human peripheral blood mono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413193b64777012464c821946f3da7a7
https://europepmc.org/articles/PMC7434464/
https://europepmc.org/articles/PMC7434464/
Autor:
Kyle Tamshen, Heather D. Maynard, Uland Y. Lau, Emma M. Pelegri-O’Day, Nicholas M. Matsumoto, Eric D. Raftery
Publikováno v:
Bioconjugate chemistry. 29(11)
Poly(ethylene glycols) (PEGs) with protein-reactive end-groups are widely utilized in bioconjugation reactions. Herein, we describe the use of ring-opening metathesis polymerization (ROMP) to synthesize unsaturated protein-reactive PEG analogs. These