Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kyle T. McKay"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Structure-based drug design targeting the SARS-CoV-2 virus has been greatly facilitated by available virus-related protein structures. However, there is an urgent need for effective, safe small-molecule drugs to control the spread of the vir
Externí odkaz:
https://doaj.org/article/2821bc4e151f414ba4c52588287f8f20
Autor:
Tyler J. Jaynes, Mona Sharafi, Joseph P. Campbell, Jessica Bocanegra, Kyle T. McKay, Kassondra Little, Reilly Osadchey Brown, Danielle L. Gray, Toby J. Woods, Jianing Li, Severin T. Schneebeli
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
This work presents the first transition metal-free synthesis of oxygen-linked aromatic polymers by integrating iterative exponential polymer growth (IEG) with nucleophilic aromatic substitution (SNAr) reactions. Our approach applies methyl sulfones a
Externí odkaz:
https://doaj.org/article/54d5f6dd58f64d3dbc7852b28719d395
Autor:
Jacob M Remington, Kyle T McKay, Noah B Beckage, Jonathon B Ferrell, Severin T. Schneebeli, Jianing Li
Publikováno v:
Journal of Computer-Aided Molecular Design. 37:147-156
Autor:
Kyle E. Murphy, Kyle T. McKay, Mica Schenkelberg, Mona Sharafi, Olav Vestrheim, Monika Ivancic, Jianing Li, Severin T. Schneebeli
Publikováno v:
Angewandte Chemie International Edition. 61
Autor:
Kyle E. Murphy, Kyle T. McKay, Mica Schenkelberg, Mona Sharafi, Olav Vestrheim, Monika Ivancic, Jianing Li, Severin T. Schneebeli
Publikováno v:
Angewandte Chemie. 134
Autor:
Kyle E. Murphy, Kyle T. McKay, Mica Schenkelberg, Mona Sharafi, Olav Vestrheim, Monika Ivancic, Jianing Li, Severin T. Schneebeli
Publikováno v:
Angewandte Chemie (International ed. in English). 61(50)
We report a general synthetic route toward helical ladder polymers with varying spring constants, built with chirality-assisted synthesis (CAS). Under tension and compression, these shape-persistent structures do not unfold, but rather stretch and co
Autor:
Sara J. Buhrlage, William C. Hahn, Sumner Perera, Ellen Weisberg, Robert S. Magin, Kenneth C. Anderson, Dharminder Chauhan, Arghya Ray, Wai Cheung Chan, Nathan J. Schauer, Laura M. Doherty, Björn Stolte, Sirano Dhe-Paganon, Rebekka M. Roberts, Jarrod A. Marto, Wanyi Hu, Sarah A. Boswell, James D. Griffin, Scott B. Ficarro, Peter K. Sorger, Andrew O. Giacomelli, Jianing Li, Kimberly Stegmaier, Roxana E. Iacob, Kyle T. McKay, John R. Engen, Xiaoxi Liu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags from specific protein substrates in order to alter their degradation rate and sub-cellular localization. USP7 has been proposed as a therapeutic targ
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Structure-based drug design targeting the SARS-CoV-2 virus has been greatly facilitated by available virus-related protein structures. However, there is an urgent need for effective, safe small-molecule drugs to control the spread of the virus and va
Autor:
Dillon R. McCarthy, Alexander Wurthmann, Jianing Li, Kyle T. McKay, Joseph P. Campbell, Ramya Srinivasan, Jonathon B. Ferrell, Severin T. Schneebeli, Xiaochuan Zhao, Magenta J. Hensinger
Publikováno v:
Journal of Chemical Education. 96:1961-1966
While virtual reality (VR) is emerging as an interactive tool for chemical education, its application and assessment for chemical education are still limited. Thus, an educational VR activity based...
Publikováno v:
Biophysical Journal
Large-scale conformational transitions in the spike protein S2 domain are required during host-cell infection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Although conventional molecular dynamics simulations have been ex