Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kyle T. Blair"'
Autor:
Kevin Daniel Freeman-Cook, Katherine E. Brighty, Phuong Le, Michael Scott Visser, Gary J. Martinelli, Sarah K. Wade, Steven J. Brickner, Dianna E. Moore, Rhonda Monahan, Kyle T. Blair
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6730-6734
Novel hygromycin A derivatives bearing a variety of functionalized aminocyclitol moieties have been synthesized in an effort to increase the antibacterial activity and drug-like properties of this class of agents. A systematic study of the effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd3fd9b256be349e2e6da8955d6667d
https://doi.org/10.1016/j.bmcl.2010.08.139
https://doi.org/10.1016/j.bmcl.2010.08.139
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1747-1752
The preparation of semisynthetic conformationally restricted hygromycin A analogues are described. Antibacterial results from these compounds suggest active conformations for this class of agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65d31071df1860c3782bfed215730f96
https://doi.org/10.1016/s0960-894x(97)00307-7
https://doi.org/10.1016/s0960-894x(97)00307-7
Autor:
Kyle T. Blair, Christopher S. Jones, Maria L. Muzzi, Christopher B. Cooper, Edward H. Fontaine, James W. McFarland
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:835-838
Palladium-mediated coupling of 2-(4-iodoaryl)-1,2,4-triazine-(2H,4H)-3,5-diones with variously substituted vinylstannanes has been examined in efforts to explore the SAR of novel triazine anticoccidials. Conventional procedures were employed for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::282dba3c47f0171690f8277fdde2a9ea
https://doi.org/10.1016/s0960-894x(01)80858-1
https://doi.org/10.1016/s0960-894x(01)80858-1
Synthesis and vitro antibacterial activity of hygromycin a analogs modified at the C4′ aryl position
Autor:
Douglas L. Schicho, Burton H. Jaynes, Scott J. Hecker, Susan C. Lilley, Kim M. Werner, Christopher B. Cooper, Kyle T. Blair, Martha L. Minich, Nancy C. Elliott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1531-1536
A variety of hygromycin A analogs are described which contain modifications of or replacements for the natural sugar. Antibacterial activities against Serpulina (Treponema) hyodysenteriae , an important animal health pathogen, are reported and indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0a7e3717644a237d2265d609c8bfb12
https://doi.org/10.1016/s0960-894x(00)80012-8
https://doi.org/10.1016/s0960-894x(00)80012-8
Autor:
Scott J. Hecker, Martha L. Minich, Kim M. Werner, Kyle T. Blair, Susan C. Lilley, Christopher B. Cooper
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:289-294
Syntheses of analogs exploring the SAR of the aryl region of hygromycin A are described. Antibacterial activities against Serpulina (Treponema) hyodysenteriae and Pasteurella multocida, two key animal health pathogens, are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d752bcb4b74e1566cfca9032122581b
https://doi.org/10.1016/s0960-894x(01)80895-7
https://doi.org/10.1016/s0960-894x(01)80895-7
Publikováno v:
ChemInform. 28
The preparation of semisynthetic conformationally restricted hygromycin A analogues are described. Antibacterial results from these compounds suggest active conformations for this class of agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45729ec2a033518b11b35a92180733d
https://doi.org/10.1002/chin.199746240
https://doi.org/10.1002/chin.199746240