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of 10
pro vyhledávání: '"Kyle T S, Pattinson"'
Autor:
Sarah L Finnegan, David J Dearlove, Peter Morris, Daniel Freeman, Martin Sergeant, Stephen Taylor, Kyle T S Pattinson
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0270721 (2023)
IntroductionThe sensation of breathlessness is often attributed to perturbations in cardio-pulmonary physiology, leading to changes in afferent signals. New evidence suggests that these signals are interpreted in the light of prior "expectations". A
Externí odkaz:
https://doaj.org/article/dbd1a054451047afa9b19252ef77e80b
Autor:
Matthew J. Rowland, Payashi Garry, Martyn Ezra, Rufus Corkill, Ian Baker, Peter Jezzard, Jon Westbrook, Gwenaëlle Douaud, Kyle T. S. Pattinson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The first 72 h following aneurysm rupture play a key role in determining clinical and cognitive outcomes after subarachnoid haemorrhage (SAH). Yet, very little is known about the impact of so called “early brain injury” on patents with c
Externí odkaz:
https://doaj.org/article/6c85b39ff6f34420a0acc33093394972
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
PurposeHypercapnic chemosensitivity traditionally captures the ventilatory response to elevated pressures of carbon dioxide in the blood. However, hypercapnia also contributes to subjective breathing perceptions, and previously we demonstrated a clos
Externí odkaz:
https://doaj.org/article/234ee367156f493db4496993cad69c25
Publikováno v:
Frontiers in Human Neuroscience, Vol 7 (2013)
The brainstem is directly involved in controlling blood pressure, respiration, sleep/wake cycles, pain modulation, motor and cardiac output. As such it is of significant basic science and clinical interest. However, the brainstem’s location close t
Externí odkaz:
https://doaj.org/article/ecbf0eca73e8423f97f11ecb966c1c64
Publikováno v:
NeuroImage. 186
In this work, we investigate the regional characteristics of the dynamic interactions between arterial CO
Autor:
Anja, Hayen, Vishvarani, Wanigasekera, Olivia K, Faull, Stewart F, Campbell, Payashi S, Garry, Simon J M, Raby, Josephine, Robertson, Ruth, Webster, Richard G, Wise, Mari, Herigstad, Kyle T S, Pattinson
Publikováno v:
Neuroimage
Opioid painkillers are a promising treatment for chronic breathlessness, but are associated with potentially fatal side effects. In the treatment of breathlessness, their mechanisms of action are unclear. A better understanding might help to identify
Autor:
Kyle T S, Pattinson, Richard G, Wise
Publikováno v:
Advances in experimental medicine and biology. 903
Opioid analgesia is limited by the potentially fatal side effect of respiratory depression. In humans the brain mechanisms of opioid-induced respiratory depression are poorly understood. Investigating pharmacological influences upon breathing helps u
Publikováno v:
Respiratory Physiology & Neurobiology
Highlights • The first cue-based task to explore recall of dyspnoea and dyspnoea-related anxiety in COPD. • Patients’ dyspnoea and dyspnoea-anxiety ratings agreed with established measures of dyspnoea. • Patients’ dyspnea-anxiety ratings ch
Autor:
Mari, Herigstad, Anja, Hayen, Eleanor, Evans, Frances M, Hardinge, Robert J, Davies, Katja, Wiech, Kyle T S, Pattinson
Publikováno v:
Chest
BACKGROUND: Dyspnea is the major source of disability in COPD. In COPD, environmental cues (eg, the prospect of having to climb stairs) become associated with dyspnea and may trigger dyspnea even before physical activity commences. We hypothesized th
Publikováno v:
Respiratory Physiology & Neurobiology
Highlights • Functional neuroimaging is poised to understand brain processing of dyspnoea. • Experimental dyspnoea alters PaCO2, which confounds FMRI contrast. • Experimentally stabilizing CO2 had minimal effects on perception of respiratory lo