Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kyle Stearns"'
Autor:
Tara C. Marcink, Gillian Zipursky, Elizabeth B. Sobolik, Kate Golub, Emily Herman, Kyle Stearns, Alexander L. Greninger, Matteo Porotto, Anne Moscona
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Paramyxoviruses including measles, Nipah, and parainfluenza viruses are public health threats with pandemic potential. Human parainfluenza virus type 3 (HPIV3) is a leading cause of illness in pediatric, older, and immunocompromised populati
Externí odkaz:
https://doaj.org/article/d6338bf3d6fc4f57af5e347e7d359d1a
Autor:
Kyle Stearns, George Lampe, Rachel Hanan, Tara Marcink, Stefan Niewiesk, Samuel H. Sternberg, Alexander L. Greninger, Matteo Porotto, Anne Moscona
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT Human parainfluenza virus 3 (HPIV3) infection is driven by the coordinated action of viral surface glycoproteins hemagglutinin-neuraminidase (HN) and fusion protein (F). Receptor-engaged HN activates F to insert into the target cell membrane
Externí odkaz:
https://doaj.org/article/1b9b1509766f4952b1c50d056dda649c
Autor:
Monica P. Goldklang, Yared Tekabe, Tina Zelonina, Jordis Trischler, Rui Xiao, Kyle Stearns, Krissy Rodriguez, Alexander Shields, Alexander Romanov, Jeanine M. D’Armiento, Lynne L. Johnson
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Expression of the Receptor for Advanced Glycation Endproducts (RAGE) initiates pro-inflammatory pathways resulting in lung destruction. We hypothesized that RAGE directed imaging demonstrates increased lung uptake in smoke-exposur
Externí odkaz:
https://doaj.org/article/5a7b49e7264a4b3eacbc050b1c545fa7
Autor:
Kyle Stearns, Monica Goldklang, Rui Xiao, Tina Zelonina, Keith Blomenkamp, Jeffery Teckman, Jeanine M D'Armiento
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246040 (2021)
Alpha-1 Antitrypsin (AAT) is a serum protease inhibitor that regulates increased lung protease production induced by cigarette smoking. Mutations in the Serpina1 gene cause AAT to form hepatoxic polymers, which can lead to reduced availability for th
Externí odkaz:
https://doaj.org/article/6dbc32e4636a4cb18f57da17ebf73c8b
Autor:
David Ng, Ana Pinharanda, Merly C Vogt, Ashok Litwin-Kumar, Kyle Stearns, Urvashi Thopte, Enrico Cannavo, Armen Enikolopov, Felix Fiederling, Stylianos Kosmidis, Barbara Noro, Ines Rodrigues-Vaz, Hani Shayya, Peter Andolfatto, Darcy S Peterka, Tanya Tabachnik, Jeanine D'Armiento, Monica Goldklang, Andres Bendesky
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257464 (2021)
Despite the development of effective vaccines against SARS-CoV-2, epidemiological control of the virus is still challenging due to slow vaccine rollouts, incomplete vaccine protection to current and emerging variants, and unwillingness to get vaccina
Externí odkaz:
https://doaj.org/article/40755ad4580445b78521b0b9e5301357
Autor:
Tara C. Marcink, Gillian Zipursky, Wenjing Cheng, Kyle Stearns, Shari Stenglein, Kate Golub, Frances Cohen, Francesca Bovier, Daniel Pfalmer, Alexander L. Greninger, Matteo Porotto, Amedee des Georges, Anne Moscona
Publikováno v:
Science Advances. 9
Paramyxoviruses—including important pathogens like parainfluenza, measles, and Nipah viruses—use a receptor binding protein [hemagglutinin-neuraminidase (HN) for parainfluenza] and a fusion protein (F), acting in a complex, to enter cells. We use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::505d1332c138a791a34b82c396aa7528
https://doi.org/10.1126/sciadv.ade2727
https://doi.org/10.1126/sciadv.ade2727
Autor:
Rory D. de Vries, Sander Herfst, Barry Rockx, Camilla Predella, Rik L. de Swart, Kyle Stearns, Jonathan Khao, Samuel H. Gellman, Anne Moscona, Danny Noack, Gaël McGill, Bart L. Haagmans, N. Valerio Dorrello, Matteo Porotto, Francesca T. Bovier, Christopher A. Alabi, Sudipta Biswas, Jennifer Drew-Bear, Katharina S. Schmitz
Publikováno v:
Science, 371(6536), 1379-1382. American Association for the Advancement of Science
Science (New York, N.y.)
Science (New York, N.y.)
Halting transmission The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein binds to host cells and initiates membrane fusion and cell infection. This stage in the virus life history is currently a target for drug inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3ce9eda821bff8423c3e97ae255580
https://doi.org/10.1126/science.abf4896
https://doi.org/10.1126/science.abf4896
Autor:
Adam Gerber, Monica P. Goldklang, Jeanine D'Armiento, Tina Zelonina, Xinran Ma, Rui Xiao, Kyle Stearns
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Acute respiratory distress syndrome (ARDS) is characterized by pulmonary edema and poor gas exchange resulting from severe inflammatory lung injury. Neutrophilic infiltration and increased pulmonary vascular permeability are hallmarks of early ARDS a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695e675addaaca0bae665753ebc85e22
https://doi.org/10.1152/ajplung.00420.2019
https://doi.org/10.1152/ajplung.00420.2019
Autor:
Tina Zelonina, Monica P. Goldklang, Lynne L. Johnson, Kyle Stearns, Jeanine D'Armiento, Rui Xiao, Yared Tekabe, Jordis Trischler, Alexander Shields, Krissy Rodriguez, Alexander Romanov
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-9 (2019)
Respiratory Research
Respiratory Research
Background Expression of the Receptor for Advanced Glycation Endproducts (RAGE) initiates pro-inflammatory pathways resulting in lung destruction. We hypothesized that RAGE directed imaging demonstrates increased lung uptake in smoke-exposure. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d198ed172ab81f5617b9b5e7079547
http://link.springer.com/article/10.1186/s12931-019-1064-4
http://link.springer.com/article/10.1186/s12931-019-1064-4
Autor:
Keith Blomenkamp, Kyle Stearns, Tina Zelonina, Jeffery H. Teckman, Rui Xiao, Monica P. Goldklang, Jeanine D'Armiento
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246040 (2021)
PLoS ONE
PLoS ONE
Alpha-1 Antitrypsin (AAT) is a serum protease inhibitor that regulates increased lung protease production induced by cigarette smoking. Mutations in the Serpina1 gene cause AAT to form hepatoxic polymers, which can lead to reduced availability for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd56e8cc67e6584edae99af05c2117a
https://doaj.org/article/6dbc32e4636a4cb18f57da17ebf73c8b
https://doaj.org/article/6dbc32e4636a4cb18f57da17ebf73c8b