Výsledky vyhledávání - "Kyle St. Louis"

Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models

Autor: Andreas Hermann, Arun Pal, Heather D. Durham, Kyle St. Louis, Sandra Minotti, Mario Fernandez, Rachel Kuta, Josephine Nalbantoglu, Michael Tibshirani, Nancy Larochelle, Benoit J. Gentil

Publikováno v: Cell Stress & Chaperones
Cell stress & chaperones 25(1), 173-191 (2020). doi:10.1007/s12192-019-01064-1

Upregulation of heat shock proteins (HSPs) is an approach to treatment of neurodegenerative disorders with impaired proteostasis. Many neurons, including motor neurons affected in amyotrophic lateral sclerosis (ALS), are relatively resistant to stres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b788104ea63c53e126e0be78e5ed78d4
https://pubmed.ncbi.nlm.nih.gov/31900865

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Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle

Autor: Kyle St. Louis, Sarah E. Gartside, Benoit J. Gentil, Kathryn White, Douglas C. Wallace, Martin Picard, Meagan J. McManus, Douglass M. Turnbull

Publikováno v: Journal of Applied Physiology

A unique property of mitochondria in mammalian cells is their ability to physically interact and undergo dynamic events of fusion/fission that remodel their morphology and possibly their function. In cultured cells, metabolic perturbations similar to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce4d2624f4c8066b52816eb4d70cd4f
https://pubmed.ncbi.nlm.nih.gov/23970537

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