Výsledky vyhledávání - "Kyle Siefers"

High trans but not saturated fat beverage causes an acute reduction in postprandial vascular endothelial function but not arterial stiffness in humans

Autor: Kaitlyn Dubishar, Jordan R Witmer, Lauren J Points, Janie Myers, Lyndsey E. DuBose, Gary L. Pierce, Kyle Siefers, Catherine A. Chenard, Abbi D. Lane-Cordova

Publikováno v: Vascular Medicine. 21:429-436

A diet high in trans-fatty acids (TFAs) is associated with a higher risk of cardiovascular disease (CVD) than a diet high in saturated fatty acids (SFAs), but the mechanisms remain unclear. We hypothesized that a beverage high in TFAs would cause a l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8a4ba72b4e6074125a42472c5c5d8d
https://doi.org/10.1177/1358863x16656063

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Micropore closure kinetics are delayed following microneedle insertion in elderly subjects

Autor: Megan N. Kelchen, Grant O. Holdren, Kyle Siefers, Matthew J. Farley, Courtney C. Converse, Nicole K. Brogden

Publikováno v: Journal of Controlled Release. 225:294-300

Transdermal delivery is an advantageous method of drug administration, particularly for an elderly population. Microneedles (MNs) allow transdermal delivery of otherwise skin-impermeable drugs by creating transient micropores that bypass the barrier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9109a7bd1324aa3e4d84a1f963560ab6
https://doi.org/10.1016/j.jconrel.2016.01.051

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Sodium salicylate prevents TNF alpha‐induced reductions in insulin‐stimulated eNOS ser1177 phosphorylation but not Akt in human aortic endothelial cells

Autor: Ramsan Younatham, Gary L. Pierce, Lauren Wegman-Points, Kyle Siefers

Publikováno v: The FASEB Journal. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb89e4efa0699fbce4221b45b20ab766
https://doi.org/10.1096/fasebj.29.1_supplement.802.5

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Sodium salicylate rescues inflammation‐associated decrease in phosphorylated‐eNOSser1177 in human aortic endothelial cells through an AMPK dependent mechanism (LB706)

Autor: Kyle Siefers, Lauren Wegman‐Points, Jordan Witmer, Gary Pierce

Publikováno v: The FASEB Journal. 28

Obesity is associated with impaired nitric oxide (NO)-mediated vascular endothelial function (VEF). Pro-inflammatory cytokines, such as TNF, may contribute to reduced VEF in part through a direct r...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::605a1b3e4b9507f144d8c8b361f2e7dd
https://doi.org/10.1096/fasebj.28.1_supplement.lb706

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Lower soluble RAGE and higher aortic stiffness in African American adolescents: possible protective effect of higher sRAGE in white youth (867.10)

Autor: Mohana Pajaniappan, Kyle Siefers, Lauren Wegman-Points, Ericka Tank, Mark A. Guinter, Katherine Darracott, Gary L. Pierce

Publikováno v: The FASEB Journal. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::118aa2098ed8d2727e41d8d636e657ac
https://doi.org/10.1096/fasebj.28.1_supplement.867.10

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Comment on Goldfine et al. Targeting Inflammation Using Salsalate in Patients With Type 2 Diabetes: Effects on Flow-Mediated Dilation (TINSAL-FMD). Diabetes Care 2013;36:4132–4139

Autor: Kyle Siefers, Gary L. Pierce, Lauren Wegman-Points

Publikováno v: Diabetes Care

We read with interest the study by Goldfine et al. (1) in the recent issue of Diabetes Care that reported that 3 and 6 months of oral salsalate treatment, as part of the multicenter Targeting Inflammation Using Salsalate in Type 2 Diabetes (TINSAL-T2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d0d69e8f634930b5189d798d1b5c58
http://europepmc.org/articles/PMC4876757

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