Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis[S]

Autor: Ani Manichaikul, Xin-Qun Wang, Wei Zhao, Mary K. Wojczynski, Kyle Siebenthall, John A. Stamatoyannopoulos, Danish Saleheen, Ingrid B. Borecki, Muredach P. Reilly, Stephen S. Rich, Karin E. Bornfeldt

Publikováno v: Journal of Lipid Research, Vol 57, Iss 3, Pp 433-442 (2016)

Long-chain acyl-CoA synthetase 1 (ACSL1) converts free fatty acids into acyl-CoAs. Mouse studies have revealed that ACSL1 channels acyl-CoAs to β-oxidation, thereby reducing glucose utilization, and is required for diabetes-accelerated atheroscleros

Externí odkaz: https://doaj.org/article/3609d1fa6ebb437dbf6eb9c2c883845a

Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis[S]

Autor: Wei Zhao, Danish Saleheen, Ingrid B. Borecki, Xin-Qun Wang, Stephen S. Rich, Ani Manichaikul, John A. Stamatoyannopoulos, Muredach P. Reilly, Kyle Siebenthall, Karin E. Bornfeldt, Mary K. Wojczynski

Publikováno v: Journal of Lipid Research, Vol 57, Iss 3, Pp 433-442 (2016)

Long-chain acyl-CoA synthetase 1 (ACSL1) converts free fatty acids into acyl-CoAs. Mouse studies have revealed that ACSL1 channels acyl-CoAs to β-oxidation, thereby reducing glucose utilization, and is required for diabetes-accelerated atheroscleros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7fac6d86833bae88d101b1cd29ad27
http://www.sciencedirect.com/science/article/pii/S0022227520354420

Integrated Functional Genomic Analysis Enables Annotation of Kidney Genome-Wide Association Study Loci

Autor: Daniel Bates, Karsten B. Sieber, J. K. Nelson, Michelle McNulty, Richard Sandstrom, Aakash Sur, Douglass Dunn, Shawn Sullivan, Dawn Waterworth, Shreeram Akilesh, Anna Batorsky, Rajinder Kaul, Jeff Vierstra, Charles E. Alpers, Michael Buckley, Kelly L. Hudkins, Matthew G. Sampson, Alex Reynolds, Jonathan Himmelfarb, Kyle Siebenthall, Morgan Diegel

Publikováno v: Journal of the American Society of Nephrology : JASN.

Background Linking genetic risk loci identified by genome-wide association studies (GWAS) to their causal genes remains a major challenge. Disease-associated genetic variants are concentrated in regions containing regulatory DNA elements, such as pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d425ec13b8b30d3dbb42cc7335b423d6
https://pubmed.ncbi.nlm.nih.gov/30760496

Integrative analysis of 111 reference human epigenomes

Autor: Daofeng Li, Tim R. Mercer, Wei Li, Lisa Helbling Chadwick, Jesse R. Dixon, Pouya Kheradpour, Joseph F. Costello, Pradipta R. Ray, John W. Whitaker, Peggy J. Farnham, Angela Tam, Vitor Onuchic, Robert A. Waterland, Misha Bilenky, James A. Thomson, Zhizhuo Zhang, Yaping Liu, Gerald Quon, Andrew J. Mungall, Steven J.M. Jones, Bradley E. Bernstein, Alexander Meissner, Melina Claussnitzer, Charles B. Epstein, Andreas R. Pfenning, Li-Huei Tsai, Laurie A. Boyer, Angela Yen, Ting Wang, Rajinder Kaul, Alireza Heravi-Moussavi, Danny Leung, Noam Shoresh, Michael T. McManus, Michael Stevens, John A. Stamatoyannopoulos, Mukul S. Bansal, Thea D. Tlsty, Susan J. Fisher, Manolis Kellis, Michael Q. Zhang, Aleksandar Milosavljevic, Viren Amin, Martin Hirst, Matthew D. Schultz, Joseph R. Ecker, Xinchen Wang, Jie Wu, Marco A. Marra, Kyle Siebenthall, Wei Wang, Ashwinikumar Kulkarni, Peter J. Sabo, R. Scott Hansen, Jianrong Wang, Michael J. Ziller, Richard A. Moore, Shane Neph, Richard C Sallari, Robert E. Thurman, Paz Polak, Wei Xie, Eric Chuah, Jason Ernst, Bing Ren, Nisha Rajagopal, Anshul Kundaje, Xin Zhou, Yi-Chieh Wu, Shamil R. Sunyaev, Ginell Elliott, Philippe Gascard, Soheil Feizi, Chibo Hong, R. Alan Harris, Ah Ram Kim, Philip L. De Jager, Rosa Karlic, R. David Hawkins, Matthew L. Eaton, Ryan Lister, Rebecca F. Lowdon, Annaick Carles, Elizabeta Gjoneska, David Haussler, Abhishek Sarkar, Nicholas A Sinnott-Armstrong, Wouter Meuleman, Lucas D. Ward, Kai How Farh, Richard Sandstrom, Arthur E. Beaudet, Theresa K. Canfield, Cristian Coarfa, Bo Zhang

Publikováno v: PMC
Nature

The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af3667ce2b614a8ae84b101ff001d0c
https://orcid.org/0000-0003-2450-736X

Genome variation and evolution of the malaria parasite Plasmodium falciparum

Autor: Daniel C. Jeffares, James Stalker, Emmanouil T. Dermitzakis, Michael A. Quail, Chris I. Newbold, Andrew Berry, Sue Kyes, Anne-Catrin Uhlemann, Anthony V Cox, Alan W. Thomas, Catherine E. Ingle, Sanjeev Krishna, Matthew Berriman, Kyle Siebenthall, Arnab Pain

Publikováno v: Nature genetics. 39(1)

Infections with the malaria parasite Plasmodium falciparum result in more than 1 million deaths each year worldwide. Deciphering the evolutionary history and genetic variation of P. falciparum is critical for understanding the evolution of drug resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd29c4b2547897a4398ab43c66eb1e2
https://pubmed.ncbi.nlm.nih.gov/17192778