Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kyle S Cole"'
Autor:
Olga Gorelenkova Miller, Kyle S Cole, Corey C Emerson, Dharmaraja Allimuthu, Marcin Golczak, Phoebe L Stewart, Eranthie Weerapana, Drew J Adams, John J Mieyal
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187991 (2017)
Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates. Grx1 is known to be a key regulator of pro-inflammatory signaling, and Grx1 silencing inhibits infl
Externí odkaz:
https://doaj.org/article/1946c27c3e7a4148add6193db46da8d3
Autor:
Andrew R. Henderson, Corinna S. Schindler, Eranthie Weerapana, Kyle S. Cole, Aaron J. Maurais, James R. Annand, Yejun Liu, Angela N. Koehler, Jorge Becerra, Anna K. Mapp
Publikováno v:
ACS Med Chem Lett
[Image: see text] The small molecule gibberellin JRA-003 was identified as an inhibitor of the NF-kB (nuclear kappa-light-chain-enhancer of activated B cells) pathway. Here we find that JRA-003 binds to and significantly inhibits the nuclear transloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a3be26f506b3f8b727bc5dd63cce38
https://doi.org/10.1021/acsmedchemlett.9b00613
https://doi.org/10.1021/acsmedchemlett.9b00613
Autor:
Yanke Liang, Mathew E. Sowa, Katrina L. Jackson, Jeffrey R. Simard, Bridget Kreger, Ping Li, Laura Poling, Joelle Baddour, Andrew Good, Hongwei Huang, Scott Eron, Christopher G. Nasveschuk, Robert Yu, Mark Fitzgerald, Victoria Garza, Morgan W. O’Shea, Gesine Veits, Jeremy Y. Yap, Moses Moustakim, Ashley Hart, Roman V. Agafonov, Grace Sarkissian, Joe S. Patel, Richard Deibler, Kyle S. Cole, David Cocozziello, Fazlur Rahman, Andrew J. Phillips, Elizabeth Norton, Adam S. Crystal, Roy M. Pollock, Stewart L. Fisher
Publikováno v:
Cancer Research. 83:3425-3425
The BRAF kinase plays a critical role in the MAPK signaling pathway and is mutated in ~8% of all human cancers including melanoma (~60%), thyroid (~60%), and lung adenocarcinoma (~10%). The most common mutation in BRAF is V600E (Class I), which is fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eb2b150c4dde824e5ce0d7e8249985a
https://doi.org/10.1158/1538-7445.am2023-3425
https://doi.org/10.1158/1538-7445.am2023-3425
Autor:
Mathew E. Sowa, Bridget Kreger, Joelle Baddour, Yanke Liang, Jeffrey R. Simard, Laura Poling, Ping Li, Robert Yu, Ashley Hart, Roman V. Agafonov, Grace Sarkissian, Joe Sahil Patel, Richard Deibler, Kyle S. Cole, Scott Eron, David Cocozziello, Fazlur Rahman, Moses Moustakim, Christopher G. Nasveschuk, Katrina L. Jackson, Mark Fitzgerald, Victoria Garza, Morgan O’Shea, Gesine Veits, Jeremy L. Yap, Andrew J. Phillips, Elizabeth Norton, Adam S. Crystal, Stewart L. Fisher, Roy M. Pollock
Publikováno v:
Cancer Research. 82:2158-2158
The BRAF kinase is a critical node in the MAPK signaling pathway and is mutated in approximately 8% of human cancers including melanoma (~60%), thyroid (~60%), and lung adenocarcinoma (~10%). The most common mutation in BRAF is V600E (Class I), occur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f785dda79bcc9822c5d07c44e6bcdb69
https://doi.org/10.1158/1538-7445.am2022-2158
https://doi.org/10.1158/1538-7445.am2022-2158
Autor:
Shabaz Mohammed, Eranthie Weerapana, Kazuko Yamaguchi-Shinozaki, Kyle S. Cole, Markus Kaiser, Jiorgos Kourelis, Daniel Krahn, Renier A. L. van der Hoorn, Dan Brown, Farnusch Kaschani, Collin H. Witt, Jonathan W. Burton, Kyoko Morimoto, Monika Stegmann
Publikováno v:
Plant Physiol
Though they are rare in nature, anthropogenic 1,3,5-triazines have been used in herbicides as chemically stable scaffolds. Here, we show that small 1,3,5-triazines selectively target ascorbate peroxidases (APXs) in Arabidopsis (Arabidopsis thaliana),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53f520ee0231e16173efe73cd1bae11
https://europepmc.org/articles/PMC6670103/
https://europepmc.org/articles/PMC6670103/
Autor:
Kenny Chen, Julia M. D. Grandjean, Eranthie Weerapana, Kyle S. Cole, R. Luke Wiseman, Collin H. Witt, Johanna J. O’Day, Matthew D. Shoulders
Publikováno v:
Biochemistry. 57(13)
Protein disulfide isomerase A1 (PDIA1) is an endoplasmic reticulum (ER)-localized thiol-disulfide oxidoreductase that is an important folding catalyst for secretory pathway proteins. PDIA1 contains two active-site domains (a and a′), each containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecd03bdf01af4212bec298ab0cf0483
https://pubmed.ncbi.nlm.nih.gov/29521097
https://pubmed.ncbi.nlm.nih.gov/29521097
Autor:
Kayla M. Bassett, Challa V. Kumar, Jessamyn R. Ward, Omkar V. Zore, Caterina Riccardi, Kyle S. Cole, Kyle R. Benson, Bobbi S. Stromer, Rajeswari M. Kasi, Yiren Zhang
Publikováno v:
Bioconjugate Chemistry. 25:1501-1510
Several key properties of catalase such as thermal stability, resistance to protease degradation, and resistance to ascorbate inhibition were improved, while retaining its structure and activity, by conjugation to poly(acrylic acid) (PAA, Mw 8000) vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330325eb279fec02908097221b8c1d3a
https://doi.org/10.1021/bc500233u
https://doi.org/10.1021/bc500233u
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a130dd32b3f40accf881f54c83cfd913
https://doi.org/10.1096/fasebj.29.1_supplement.721.21
https://doi.org/10.1096/fasebj.29.1_supplement.721.21
Autor:
Marcin Golczak, Eranthie Weerapana, Dharmaraja Allimuthu, John J. Mieyal, Olga Gorelenkova Miller, Corey C. Emerson, Phoebe L. Stewart, Kyle S. Cole, Drew J. Adams
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0187991 (2017)
PLoS ONE, Vol 12, Iss 11, p e0187991 (2017)
Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates. Grx1 is known to be a key regulator of pro-inflammatory signaling, and Grx1 silencing inhibits infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77404589ba30740781fafe7b2fcade64
https://doi.org/10.1371/journal.pone.0187991
https://doi.org/10.1371/journal.pone.0187991
Autor:
Yuxiang Zhou, Vamsi K. Mudhivarthi, Inoka K. Deshapriya, Kyle S. Cole, Marc J. Novak, Westley Kipphut, Challa V. Kumar, Rajeswari M. Kasi
Publikováno v:
Journal of Materials Chemistry. 22:20423
Stabilization of proteins against thermal deactivation is a major challenge, and a simple, facile, novel chemical approach is described here to overcome this hurdle. We report here, for the first time, the successful synthesis of ultrastable protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20764519d0fd5d7fa82203acc79d933d
https://doi.org/10.1039/c2jm34434c
https://doi.org/10.1039/c2jm34434c