Výsledky vyhledávání - "Kyle S Cavagnini"

Requirement of hepatic pyruvate carboxylase during fasting, high fat, and ketogenic diet

Autor: Ebru S. Selen, Susana Rodriguez, Kyle S. Cavagnini, Han-Byeol Kim, Chan Hyun Na, Michael J. Wolfgang

Publikováno v: The Journal of biological chemistry. 298(12)

Pyruvate has two major fates upon entry into mitochondria, the oxidative decarboxylation to acetyl-CoA via the pyruvate decarboxylase complex or the biotin-dependent carboxylation to oxaloacetate via pyruvate carboxylase (Pcx). Here, we have generate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16191059c0ea1408e5316554ffe665f1
https://pubmed.ncbi.nlm.nih.gov/36441025

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Pparα and fatty acid oxidation coordinate hepatic transcriptional architecture

Autor: Michael J. Wolfgang, Kyle S. Cavagnini

Fasting requires tight coordination between the metabolism and transcriptional output of hepatocytes to maintain systemic glucose and lipid homeostasis. Deficits in hepatic fatty acid oxidation result in dramatic fasting-induced hepatocyte lipid accu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94ef6ab5bb82ec27c4e49c825ab580a1
https://doi.org/10.1101/2021.07.12.451949

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Maternal Lipid Metabolism Directs Fetal Liver Programming following Nutrient Stress

Autor: Susanna Scafidi, Danielle M. Smith, Ebru S. Selen Alpergin, Kyle S. Cavagnini, Michael J. Wolfgang, Caitlyn E. Bowman

Publikováno v: Cell Reports, Vol 29, Iss 5, Pp 1299-1310.e3 (2019)
Cell reports

SUMMARY The extreme metabolic demands of pregnancy require coordinated metabolic adaptations between mother and fetus to balance fetal growth and maternal health with nutrient availability. To determine maternal and fetal contributions to metabolic f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc8192c8db5c7d7ca1a4611754973ba
https://doi.org/10.1016/j.celrep.2019.09.053

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A Gα12-specific Binding Domain in AKAP-Lbc and p114RhoGEF

Autor: Joseph W. Martin, William C. Smolski, Autumn L. Towne, Douglas N. Brawley, Jonathan Sims, Carrie Y. Berkley, Thomas E. Meigs, Kyle S Cavagnini, Ricardo D. Garcia

Publikováno v: Journal of Molecular Signaling; Vol 11 (2016); 3
Journal of Molecular Signaling

AKAP-Lbc is a Rho-activating guanine nucleotide exchange factor (RhoGEF) important in heart development and pro-fibrotic signaling in cardiomyocytes. Heterotrimeric G proteins of the G12/13 subfamily, comprising Gα12 and Gα13, are well characterize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00403ef4d2bd5d652284d4193fe2bc29
http://www.jmolecularsignaling.com/jms/article/view/1750-2187-11-3

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