Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kyle S Buchholz"'
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 11, p e1005854 (2017)
Mechanical strain is a potent stimulus for growth and remodeling in cells. Although many pathways have been implicated in stretch-induced remodeling, the control structures by which signals from distinct mechano-sensors are integrated to modulate hyp
Externí odkaz:
https://doaj.org/article/857c1594eb024056bab3e833cab31e86
Autor:
Indroneal Banerjee, Jianlin Zhang, Thomas Moore-Morris, Emily Pfeiffer, Kyle S Buchholz, Ao Liu, Kunfu Ouyang, Matthew J Stroud, Larry Gerace, Sylvia M Evans, Andrew McCulloch, Ju Chen
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004114 (2014)
Recent interest has focused on the importance of the nucleus and associated nucleoskeleton in regulating changes in cardiac gene expression in response to biomechanical load. Mutations in genes encoding proteins of the inner nuclear membrane and nucl
Externí odkaz:
https://doaj.org/article/0ffa33f0b87146718f10ed4b4565896e
Publikováno v:
Nat Rev Cardiol
The intact heart undergoes complex and multiscale remodelling processes in response to altered mechanical cues. Remodelling of the myocardium is regulated by a combination of myocyte and non-myocyte responses to mechanosensitive pathways, which can a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fd1f3c7febd9d9c3c4e02dd9a31fa9
https://doi.org/10.1038/s41569-019-0155-8
https://doi.org/10.1038/s41569-019-0155-8
Autor:
Shulin Cao, Philip M. Tan, Jeffrey J. Saucerman, Andrew D. McCulloch, Yasser Aboelkassem, Kyle S. Buchholz, Jeffrey H. Omens
Publikováno v:
Molecular & Cellular Biomechanics. 16:1-3
In this article, we summarize our systems model of cardiomyocyte mechano-signaling published in PLoS Computational Biology and discuss new approaches to extending these models to predict cardiac myocyte gene expression in response to stretch.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a9f1422db752200c776a78e5d83af2
https://doi.org/10.32604/mcb.2019.05693
https://doi.org/10.32604/mcb.2019.05693
Autor:
Zhenxing Fu, Andrew D. McCulloch, Karen Ocorr, Zhuohui Gan, Rolf Bodmer, Alexander C. Zambon, Gabriel G. Haddad, Kyle S. Buchholz, Frank L. Powell, Jennifer Stowe, Esteban A. Moya
Publikováno v:
The Journal of Physiology. 595:5797-5813
KEY POINTS Changes in gene expression that occur within hours of exposure to hypoxia in in vivo skeletal muscles remain unexplored. Two hours of hypoxia caused significant down-regulation of extracellular matrix genes followed by a shift at 6 h to al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99bcb3f5955f3b60c1f39fc62cc588c0
https://doi.org/10.1113/jp274556
https://doi.org/10.1113/jp274556
Publikováno v:
The FASEB Journal. 28
Static, mechanical stretch of neonatal cardiomyocytes induces changes in gene expression and can be used as a model to study cardiac hypertrophy. It has been hypothesized that the location of mechanosensors in relation to the cytoskeletal alignment m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4f1069e3de23adee9a9381cebaecfca
https://doi.org/10.1096/fasebj.28.1_supplement.699.3
https://doi.org/10.1096/fasebj.28.1_supplement.699.3
Publikováno v:
Molecular pharmaceutics. 7(5)
Cytokine-neutralizing antibodies are used in treating a broad range of inflammatory conditions. We demonstrate that monoclonal antibodies against interleukin-1β and tumor necrosis factor-α were still active when conjugated to high molecular weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6b11380821b502b596515e323fad05
https://pubmed.ncbi.nlm.nih.gov/20726535
https://pubmed.ncbi.nlm.nih.gov/20726535