Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kyle R. Spinler"'
Autor:
Nikki K. Lytle, Hyog Young Kwon, Michael Hamilton, Jeevisha Bajaj, Ferdous Anower-E-Khuda, Tannishtha Reya, Mark H. Ginsberg, Jeffrey D. Esko, Bryan Zimdahl, Armin Ahmadi, Kyle R. Spinler, Joi Weeks, Jan Karlseder, Claire S. Koechlein, Marcie Kritzik, Hao Sun, Pyong Woo Park, Allen Blevins, Takahiro Ito
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Intratumoral heterogeneity is a common feature of many myeloid leukemias and a significant reason for treatment failure and relapse. Thus, identifying the cells responsible for residual disease and leukemia re-growth is critical to better understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d060c5584d0922de3b8568c04b179d6
https://escholarship.org/uc/item/7vk3p3vd
https://escholarship.org/uc/item/7vk3p3vd
Publikováno v:
Blood. 125:525-533
Megakaryocyte ploidy and the generation of pre/proplatelets are both increased in culture by pharmacologic inhibition of myosin-II, but nonmuscle myosin-IIA (MIIA) mutations paradoxically cause MYH9-related diseases (MYH9-RD) that adversely affect pl
Autor:
Manu Tewari, Sangkyun Cho, Yuntao Xia, Cory Alvey, Brandon H. Hayes, Kyle R. Spinler, Dennis E. Discher, Lucas R. Smith, Jerome Irianto, Jake Hsu, Charlotte R. Pfeifer, P.C.P. Dave Dingal
Publikováno v:
Current biology : CB, vol 27, iss 14
Marrow-derived macrophages are highly phagocytic, but whether they can also traffic into solid tumors and engulf cancer cells is questionable, given the well-known limitations of tumor-associated macrophages (TAMs). Here, SIRPα on macrophages from m
Publikováno v:
Molecular Biology of the Cell
Ivanovska, I L, Swift, J, Spinler, K, Dingal, D, Cho, S & Discher, D E 2017, ' Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation ', Molecular Biology of the Cell, vol. 28, no. 12 . https://doi.org/10.1091/mbc.E17-01-0010
Ivanovska, I L, Swift, J, Spinler, K, Dingal, D, Cho, S & Discher, D E 2017, ' Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation ', Molecular Biology of the Cell, vol. 28, no. 12 . https://doi.org/10.1091/mbc.E17-01-0010
A nanofilm of cross-linked collagen-I is equivalent to a relatively stiff matrix, which stiffens the nucleus, correlating broadly with lamin-A (including mutant progerin), retinoic acid transcription factor level and activity, and osteoinduction. In
Autor:
Dennis E. Discher, Kyle R. Spinler, Amnon Buxboim, Avathamsa Athirasala, Yun Ruei C Kao, Jae-Won Shin, Jerome Irianto, P.C. Dave P. Dingal, Sangkyun Cho, Takamasa Harada, Joe Swift
Publikováno v:
Current Biology. 24(16):1909-1917
SummaryTissue microenvironments are characterized not only in terms of chemical composition but also by collective properties such as stiffness, which influences the contractility of a cell, its adherent morphology, and even differentiation [1–8].
Autor:
Christopher A. Hunter, Amnon Buxboim, Joel Anne Chasis, Christian Gachet, Joe Swift, David A. Christian, P.C. Dave P. Dingal, Kyle R. Spinler, Dennis E. Discher, Irena L. Ivanovska, Florian Rehfeldt, Catherine Léon, Jae-Won Shin
Publikováno v:
Cell Stem Cell. 14:81-93
SummarySelf-renewal and differentiation of stem cells depend on asymmetric division and polarized motility processes that in other cell types are modulated by nonmuscle myosin-II (MII) forces and matrix mechanics. Here, mass spectrometry-calibrated i
Publikováno v:
Blood. 132:1727-1727
Poorly differentiated aggressive myeloid diseases such as Acute Myelogenous Leukemia (AML) and blast crisis Chronic Myelogenous Leukemia (bcCML) are often resistant to standard therapy and associated with significantly poor survival in both children
Autor:
Joe Swift, Kyle R. Spinler, Amnon Buxboim, Irena L. Ivanovska, Dennis E. Discher, Jae-Won Shin
Publikováno v:
Differentiation. 86:77-86
Adult stem cells and progenitors are of great interest for their clinical application as well as their potential to reveal deep sensitivities to microenvironmental factors. The bone marrow is a niche for at least two types of stem cells, and the prot
Autor:
Mohammad Reza Vakili, S A Karthick, Dennis E. Discher, Praful R. Nair, Kyle R. Spinler, Afsaneh Lavasanifar
Publikováno v:
Nanomedicine (London, England). 11(12)
Aim: In order to improve the delivery of aromatic drugs by micellar assemblies, and particularly by long and flexible filomicelles, aromatic groups were integrated into the hydrophobic block of a degradable diblock copolymer. Materials & methods: Aro
Publikováno v:
Biophysical Journal. 110(3)
Filoviruses such as Ebola are microns long but biophysical advantages for such encapsulating/enveloped viruses have remained obscure. Flexible ‘filomicelles’ have been made from amphiphilic block copolymers and demonstrate effective delivery of t