Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kyle R. Simonetta"'
Autor:
Kyle R. Simonetta, Joshua Taygerly, Kathleen Boyle, Stephen E. Basham, Chris Padovani, Yan Lou, Thomas J. Cummins, Stephanie L. Yung, Szerenke Kiss von Soly, Frank Kayser, John Kuriyan, Michael Rape, Mario Cardozo, Mark A. Gallop, Neil F. Bence, Paul A. Barsanti, Anjanabha Saha
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Directed protein degradation to target hard-to-drug proteins is a promising therapeutic approach. Here, the authors report the prospective discovery of small molecule “molecular glue” that inserts into a naturally occurring E3 ligase-substrate in
Externí odkaz:
https://doaj.org/article/1987a6eabdf140cbaf14746bd1ee3135
Autor:
Paul A. Barsanti, Joshua Taygerly, Kathleen Boyle, Kyle R. Simonetta, Stephanie L. Yung, Szerenke Kiss von Soly, Chris Padovani, Frank Kayser, Neil Bence, Anjanabha Saha, Stephen E. Basham, John Kuriyan, Mark Gallop, Thomas Cummins, Yan Lou, Michael Rape, Mario G. Cardozo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Simonetta, Kyle R; Taygerly, Joshua; Boyle, Kathleen; Basham, Stephen E; Padovani, Chris; Lou, Yan; et al.(2019). Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.. Nature communications, 10(1), 1402. doi: 10.1038/s41467-019-09358-9. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/26s7m3b9
Nature Communications
Nature communications, vol 10, iss 1
Simonetta, Kyle R; Taygerly, Joshua; Boyle, Kathleen; Basham, Stephen E; Padovani, Chris; Lou, Yan; et al.(2019). Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.. Nature communications, 10(1), 1402. doi: 10.1038/s41467-019-09358-9. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/26s7m3b9
Protein–protein interactions (PPIs) governing the recognition of substrates by E3 ubiquitin ligases are critical to cellular function. There is significant therapeutic potential in the development of small molecules that modulate these interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d19fdea334a0af8bb97cc6bfba60718
https://doaj.org/article/1987a6eabdf140cbaf14746bd1ee3135
https://doaj.org/article/1987a6eabdf140cbaf14746bd1ee3135
Autor:
Eric R. Goedken, Mike O'Donnell, Kyle R. Simonetta, Steven N. Seyedin, John Kuriyan, Debora L. Makino, Brian A. Kelch, Aaron J. Cantor, Randall McNally, Steven L. Kazmirski
Publikováno v:
Cell. 137:659-671
SummaryClamp loaders load sliding clamps onto primer-template DNA. The structure of the E. coli clamp loader bound to DNA reveals the formation of an ATP-dependent spiral of ATPase domains that tracks only the template strand, allowing recognition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc8432dc4e910c11b76df9ba221f162
https://doi.org/10.1016/j.cell.2009.03.044
https://doi.org/10.1016/j.cell.2009.03.044
Recombinant globular tail fragment of myosin-V blocks vesicle transport in squid nerve cell extracts
Autor:
Phillip Stafford, Leslie A. Sandberg, Jeremiah R. Brown, Kyle R. Simonetta, George M. Langford
Publikováno v:
The Biological bulletin. 201(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181188ed901cfdd60761d2cb76024dc2
https://pubmed.ncbi.nlm.nih.gov/11687400
https://pubmed.ncbi.nlm.nih.gov/11687400