Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Kyle R. Covington"'
Autor:
Sarah T. Arron, Ashley Wysong, Mary A. Hall, Christine N. Bailey, Kyle R. Covington, Sarah J. Kurley, Matthew S. Goldberg, Julia M. Kasprzak, Ally‐Khan Somani, Sherrif F. Ibrahim, David G. Brodland, Nathan J. Cleaver, Ian A. Maher, Yang Xia, Shlomo A. Koyfman, Jason G. Newman
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 7, Iss 1, Pp 135-144 (2022)
Abstract Objective Over 50% of newly diagnosed cutaneous squamous cell carcinoma (cSCC) lesions occur in the head and neck (cSCC‐HN), and metastasis to nodal basins in this region further complicates surgical and adjuvant treatment. The current stu
Externí odkaz:
https://doaj.org/article/d6cb5b0c60914e73b12b558eb7bd2bdd
Autor:
Sherri Borman, Jeff Wilkinson, Lauren Meldi-Sholl, Clare Johnson, Kelsey Carter, Kyle R. Covington, Alison L. Fitzgerald, Sarah J. Kurley, Aaron S. Farberg, Matthew S. Goldberg, Federico A. Monzon, Kristen Oelschlager, Robert W. Cook
Publikováno v:
Diagnostic Pathology, Vol 17, Iss 1, Pp 1-9 (2022)
Abstract Background To improve identification of patients with cutaneous squamous cell carcinoma (SCC) at high risk for metastatic disease, the DecisionDx-SCC assay, a prognostic 40-gene expression profile (40-GEP) test, was developed and validated.
Externí odkaz:
https://doaj.org/article/5dc0fd7c5db947d38a48484f283f51a2
Autor:
Jonathan S. Zager, Brian R. Gastman, Sancy Leachman, Rene C. Gonzalez, Martin D. Fleming, Laura K. Ferris, Jonhan Ho, Alexander R. Miller, Robert W. Cook, Kyle R. Covington, Kristen Meldi-Plasseraud, Brooke Middlebrook, Lewis H. Kaminester, Anthony Greisinger, Sarah I. Estrada, David M. Pariser, Lee D. Cranmer, Jane L. Messina, John T. Vetto, Jeffrey D. Wayne, Keith A. Delman, David H. Lawson, Pedram Gerami
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background The heterogeneous behavior of patients with melanoma makes prognostication challenging. To address this, a gene expression profile (GEP) test to predict metastatic risk was previously developed. This study evaluates the GEP’s pr
Externí odkaz:
https://doaj.org/article/51ad8d737b2d423ab145b5125b6bb24a
Autor:
Robert W. Cook, Brooke Middlebrook, Jeff Wilkinson, Kyle R. Covington, Kristen Oelschlager, Federico A. Monzon, John F. Stone
Publikováno v:
Diagnostic Pathology, Vol 13, Iss 1, Pp 1-8 (2018)
Abstract Background The DecisionDx-Melanoma test provides prognostic information for patients with cutaneous melanoma (CM). Using formalin-fixed paraffin-embedded primary tumor tissue, the RT-PCR-based test classifies patients into a low- (Class 1) o
Externí odkaz:
https://doaj.org/article/30b48c55ec324058a0a1e42655dcca7e
Autor:
Eddy C. Hsueh, James R. DeBloom, Jonathan Lee, Jeffrey J. Sussman, Kyle R. Covington, Brooke Middlebrook, Clare Johnson, Robert W. Cook, Craig L. Slingluff, Kelly M. McMasters
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-8 (2017)
Abstract Background A 31-gene expression profile (GEP) test that provides risk classification of cutaneous melanoma (CM) patients has been validated in several retrospective studies. The objective of the reported study was a prospective evaluation of
Externí odkaz:
https://doaj.org/article/73636748782a40a5b60fd2f667dbd546
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
Autor:
Farshad Farshidfar, Siyuan Zheng, Marie-Claude Gingras, Yulia Newton, Juliann Shih, A. Gordon Robertson, Toshinori Hinoue, Katherine A. Hoadley, Ewan A. Gibb, Jason Roszik, Kyle R. Covington, Chia-Chin Wu, Eve Shinbrot, Nicolas Stransky, Apurva Hegde, Ju Dong Yang, Ed Reznik, Sara Sadeghi, Chandra Sekhar Pedamallu, Akinyemi I. Ojesina, Julian M. Hess, J. Todd Auman, Suhn K. Rhie, Reanne Bowlby, Mitesh J. Borad, Andrew X. Zhu, Josh M. Stuart, Chris Sander, Rehan Akbani, Andrew D. Cherniack, Vikram Deshpande, Taofic Mounajjed, Wai Chin Foo, Michael S. Torbenson, David E. Kleiner, Peter W. Laird, David A. Wheeler, Autumn J. McRee, Oliver F. Bathe, Jesper B. Andersen, Nabeel Bardeesy, Lewis R. Roberts, Lawrence N. Kwong
Publikováno v:
Cell Reports, Vol 18, Iss 11, Pp 2780-2794 (2017)
Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer
Externí odkaz:
https://doaj.org/article/1d6e88c5fa4e40259f49eebb46d2032d
Autor:
Vida Chitsazzadeh, Cristian Coarfa, Jennifer A. Drummond, Tri Nguyen, Aaron Joseph, Suneel Chilukuri, Elizabeth Charpiot, Charles H. Adelmann, Grace Ching, Tran N. Nguyen, Courtney Nicholas, Valencia D. Thomas, Michael Migden, Deborah MacFarlane, Erika Thompson, Jianjun Shen, Yoko Takata, Kayla McNiece, Maxim A. Polansky, Hussein A. Abbas, Kimal Rajapakshe, Adam Gower, Avrum Spira, Kyle R. Covington, Weimin Xiao, Preethi Gunaratne, Curtis Pickering, Mitchell Frederick, Jeffrey N. Myers, Li Shen, Hui Yao, Xiaoping Su, Ronald P. Rapini, David A. Wheeler, Ernest T. Hawk, Elsa R. Flores, Kenneth Y. Tsai
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Cutaneous squamous cell of the skin is a common neoplasm that frequently arises from precancerous actinic keratoses. Here, the authors carry out genomic analysis on matched sets of human lesions and compare with those in ultraviolet treated mice and
Externí odkaz:
https://doaj.org/article/2337471e297249159e9e90238c07490c
Autor:
Fengju Chen, Yiqun Zhang, Yasin Şenbabaoğlu, Giovanni Ciriello, Lixing Yang, Ed Reznik, Brian Shuch, Goran Micevic, Guillermo De Velasco, Eve Shinbrot, Michael S. Noble, Yiling Lu, Kyle R. Covington, Liu Xi, Jennifer A. Drummond, Donna Muzny, Hyojin Kang, Junehawk Lee, Pheroze Tamboli, Victor Reuter, Carl Simon Shelley, Benny A. Kaipparettu, Donald P. Bottaro, Andrew K. Godwin, Richard A. Gibbs, Gad Getz, Raju Kucherlapati, Peter J. Park, Chris Sander, Elizabeth P. Henske, Jane H. Zhou, David J. Kwiatkowski, Thai H. Ho, Toni K. Choueiri, James J. Hsieh, Rehan Akbani, Gordon B. Mills, A. Ari Hakimi, David A. Wheeler, Chad J. Creighton
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2476-2489 (2016)
On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genom
Externí odkaz:
https://doaj.org/article/4a90ea0a0d7349be93c5dc15ad373d6c
Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation
Autor:
Marie-Claude Gingras, Kyle R. Covington, David K. Chang, Lawrence A. Donehower, Anthony J. Gill, Michael M. Ittmann, Chad J. Creighton, Amber L. Johns, Eve Shinbrot, Ninad Dewal, William E. Fisher, Christian Pilarsky, Robert Grützmann, Michael J. Overman, Nigel B. Jamieson, George Van Buren II, Jennifer Drummond, Kimberly Walker, Oliver A. Hampton, Liu Xi, Donna M. Muzny, Harsha Doddapaneni, Sandra L. Lee, Michelle Bellair, Jianhong Hu, Yi Han, Huyen H. Dinh, Mike Dahdouli, Jaswinder S. Samra, Peter Bailey, Nicola Waddell, John V. Pearson, Ivon Harliwong, Huamin Wang, Daniela Aust, Karin A. Oien, Ralph H. Hruban, Sally E. Hodges, Amy McElhany, Charupong Saengboonmee, Fraser R. Duthie, Sean M. Grimmond, Andrew V. Biankin, David A. Wheeler, Richard A. Gibbs
Publikováno v:
Cell Reports, Vol 14, Iss 4, Pp 907-919 (2016)
The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form a group of histopathologically heterogenous tumors. To evaluate the molecular features of these tumors, 98 ampullary adenocarcinomas were evaluated and co
Externí odkaz:
https://doaj.org/article/ed03ea58619548d2aee7acfa83a8cd5c
Autor:
Eddy C. Hsueh, James R. DeBloom, Jonathan Lee, Jeffrey J. Sussman, Kyle R. Covington, Brooke Middlebrook, Clare Johnson, Robert W. Cook, Craig L. Slingluff, Kelly M. McMasters
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-2 (2017)
Externí odkaz:
https://doaj.org/article/409b317759fe4ea6aaa18a6c88d637a2