Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Kyle R. Brimacombe"'
Autor:
Richard T. Eastman, Jacob S. Roth, Kyle R. Brimacombe, Anton Simeonov, Min Shen, Samarjit Patnaik, Matthew D. Hall
Publikováno v:
ACS Central Science, Vol 6, Iss 5, Pp 672-683 (2020)
Externí odkaz:
https://doaj.org/article/a4ba45595490437cbd845967f2031af1
Autor:
Sara E. Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Noah Z. Burns, Jin K. Cha, Emily E. Mevers, Jon Clardy, Jason A. Clement, Peter A. Crooks, Gregory D. Cuny, Jake Ganor, Jesus Moreno, Lucas A. Morrill, Elias Picazo, Robert B. Susick, Neil K. Garg, Brian C. Goess, Robert B. Grossman, Chambers C. Hughes, Jeffrey N. Johnston, Madeleine M. Joullie, A. Douglas Kinghorn, David G.I. Kingston, Michael J. Krische, Ohyun Kwon, Thomas J. Maimone, Susruta Majumdar, Katherine N. Maloney, Enas Mohamed, Brian T. Murphy, Pavel Nagorny, David E. Olson, Larry E. Overman, Lauren E. Brown, John K. Snyder, John A. Porco, Fatima Rivas, Samir A. Ross, Richmond Sarpong, Indrajeet Sharma, Jared T. Shaw, Zhengren Xu, Ben Shen, Wei Shi, Corey R.J. Stephenson, Alyssa L. Verano, Derek S. Tan, Yi Tang, Richard E. Taylor, Regan J. Thomson, David A. Vosburg, Jimmy Wu, William M. Wuest, Armen Zakarian, Yufeng Zhang, Tianjing Ren, Zhong Zuo, James Inglese, Sam Michael, Anton Simeonov, Wei Zheng, Paul Shinn, Ajit Jadhav, Matthew B. Boxer, Matthew D. Hall, Menghang Xia, Rajarshi Guha, Jason M. Rohde
Publikováno v:
ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)
Externí odkaz:
https://doaj.org/article/9f2975f36dd648f0b92b6e0f2b27c087
Autor:
Richard T. Eastman, Jacob S. Roth, Kyle R. Brimacombe, Anton Simeonov, Min Shen, Samarjit Patnaik, Matthew D. Hall
Publikováno v:
ACS Central Science, Vol 6, Iss 6, Pp 1009-1009 (2020)
Externí odkaz:
https://doaj.org/article/a4537cabe3d448828484fbcfb9641603
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Figure S4 shows the activity of non-lead compounds in secondary biological assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa4da14d7c7e052f7a053a7c7a1cad7
https://doi.org/10.1158/1535-7163.22506267.v1
https://doi.org/10.1158/1535-7163.22506267.v1
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Table S1 shows the gene and pathway analysis of genes regulated by NCGC00117362 in Kuramochi ovarian cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a687cc6a0b21cdc3190fc004856e02
https://doi.org/10.1158/1535-7163.22506243
https://doi.org/10.1158/1535-7163.22506243
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
The tumor microenvironment (TME) is a key determinant of metastatic efficiency. We performed a quantitative high-throughput screen (qHTS) of diverse medicinal chemistry tractable scaffolds (44,420 compounds) and pharmacologically active small molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e72eab370c62166cd7e7a4b4c63489d
https://doi.org/10.1158/1535-7163.c.6538335
https://doi.org/10.1158/1535-7163.c.6538335
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Methods describes the Proteomics and Gene Expression Analysis Methods and References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784ddf962fccbfa132187f45dfcd6358
https://doi.org/10.1158/1535-7163.22506246.v1
https://doi.org/10.1158/1535-7163.22506246.v1
Autor:
Sarine, Markossian, Kyle R, Brimacombe, G Sitta, Sittampalam, Abigail, Grossman, Nathan P, Coussens, James, Inglese, Douglas S, Auld, William, Chin, Christopher P, Austin, Matthew D, Hall
Publikováno v:
Nature reviews. Drug discovery. 21(12)
Autor:
Hongchao Zheng, Andrew L. McIver, Surendra Karavadhi, Adam Yasgar, William J. Moore, Li Liu, Zhuyin Li, Carleen Klumpp-Thomas, Ajit Jadhav, Natalia J. Martinez, Kyle R. Brimacombe, Mindy I. Davis, Wei Zhao, Daniel J. Urban, Stephen V. Frye, Anton Simeonov, Xiaodong Wang, Samarjit Patnaik, Rajan Pragani, Mark J. Henderson, Weihe Zhang, Melinda G. Hollingshead, Min Shen, Qingyang Liu, Gordon M. Stott, Tobie D. Lee, Sam Michael, Matthew B. Boxer, Jason M. Rohde, Matthew D. Hall, Yuhong Fang, Joseph M. Covey, Dorian M. Cheff
Publikováno v:
J Med Chem
Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are oncogenic for a number of malignancies, primarily low-grade gliomas and acute myeloid leukemia (AML). We report a medicinal chemistry campaign around a 7,7-dimethyl-7,8-dihydro-2H-1λ(2)-q
Autor:
Rajarshi Guha, Anton Simeonov, Jesus Moreno, Min Shen, Yi Tang, James Inglese, Jared T. Shaw, Jimmy Ming-Tai Wu, Samir A. Ross, Tobie D. Lee, Surendra Karavadhi, Dorian M. Cheff, Susruta Majumdar, Adam Yasgar, Richard E. Taylor, Sam Michael, Zhengren Xu, Wei Sun, Lucas A. Morrill, David A. Vosburg, Wei Zheng, Corey R. J. Stephenson, Noah Z. Burns, Michael J. Iannotti, Carleen Klumpp-Thomas, Richard T. Eastman, Ohyun Kwon, Armen Zakarian, Yufeng Zhang, Matthew D. Hall, Sara E. Kearney, Ya Qin Zhang, Tongan Zhao, Ken Cheng, Indrajeet Sharma, Nathan P. Coussens, Ruili Huang, Derek S. Tan, Paul Shinn, Michael J. Krische, Caitlin Lynch, Jon Clardy, Larry E. Overman, Kanny K. Wan, Chambers C. Hughes, Madeleine M. Joullié, Thomas J. Maimone, Matthew B. Boxer, Jason A. Clement, A. Douglas Kinghorn, Peter A. Crooks, Brian C. Goess, Robert B. Susick, Gergely Zahoránszky-Kőhalmi, Alyssa L. Verano, Danielle Bougie, Jacob S. Roth, Ben Shen, Dorjbal Dorjsuren, Elias Picazo, Jinghua Zhao, John K. Snyder, Rodrigo B. Andrade, Wei Shi, Jin K. Cha, Brian T. Murphy, Fatima Rivas, William M. Wuest, Jake Ganor, Robert B. Grossman, Pavel Nagorny, Emily Mevers, Enas I. Mohamed, David E. Olson, John A. Porco, Neil K. Garg, Srilatha Sakamuru, Jason M. Rohde, M. Kevin Brown, Menghang Xia, Tianjing Ren, Steve Titus, Christopher Dillon, Mark J. Henderson, Zhong Zuo, Regan J. Thomson, David G. I. Kingston, Lauren E. Brown, Jeffrey N. Johnston, Katherine N. Maloney, Richmond Sarpong, Zina Itkin, Gregory D. Cuny, Ajit Jadhav, Kyle R. Brimacombe
Publikováno v:
ACS Central Science
ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)
ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)
Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or com