Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kyle R Upton"'
Autor:
Katina D Hulme, Anjana C Karawita, Cassandra Pegg, Myrna JM Bunte, Helle Bielefeldt-Ohmann, Conor J Bloxham, Silvie Van den Hoecke, Yin Xiang Setoh, Bram Vrancken, Monique Spronken, Lauren E Steele, Nathalie AJ Verzele, Kyle R Upton, Alexander A Khromykh, Keng Yih Chew, Maria Sukkar, Simon Phipps, Kirsty R Short
Publikováno v:
eLife, Vol 10 (2021)
Influenza virus has a high mutation rate, such that within one host different viral variants can emerge. Evidence suggests that influenza virus variants are more prevalent in pregnant and/or obese individuals due to their impaired interferon response
Externí odkaz:
https://doaj.org/article/bf6df5e1336e47158a87381401c4414d
Autor:
Katina D Hulme, Limin Yan, Rebecca J Marshall, Conor J Bloxham, Kyle R Upton, Sumaira Z Hasnain, Helle Bielefeldt-Ohmann, Zhixuan Loh, Katharina Ronacher, Keng Yih Chew, Linda A Gallo, Kirsty R Short
Publikováno v:
eLife, Vol 9 (2020)
Diabetes mellitus is a known susceptibility factor for severe influenza virus infections. However, the mechanisms that underlie this susceptibility remain incompletely understood. Here, the effects of high glucose levels on influenza severity were in
Externí odkaz:
https://doaj.org/article/c77fdcadf032456989548c4375914ffe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract While transposons are generally silenced in somatic tissues, many transposons escape epigenetic repression in epithelial cancers, become transcriptionally active and contribute to the regulation of human gene expression. We have developed a
Externí odkaz:
https://doaj.org/article/b7fc12492b4b4d2bb4b821a58664062c
Autor:
Jiayue-Clara Jiang, Kyle R. Upton
Publikováno v:
Mobile DNA, Vol 10, Iss 1, Pp 1-14 (2019)
Abstract Background Transposable elements (TE) are commonly regarded as “junk DNA” with no apparent regulatory roles in the human genome. However, a growing body of evidence demonstrates that some TEs exhibit regulatory activities in a range of b
Externí odkaz:
https://doaj.org/article/47c33764e6e24268a9895f766cbffcb5
Autor:
Thu H.M. Nguyen, Patricia E. Carreira, Francisco J. Sanchez-Luque, Stephanie N. Schauer, Allister C. Fagg, Sandra R. Richardson, Claire M. Davies, J. Samuel Jesuadian, Marie-Jeanne H.C. Kempen, Robin-Lee Troskie, Cini James, Elizabeth A. Beaven, Tristan P. Wallis, Jermaine I.G. Coward, Naven P. Chetty, Alexander J. Crandon, Deon J. Venter, Jane E. Armes, Lewis C. Perrin, John D. Hooper, Adam D. Ewing, Kyle R. Upton, Geoffrey J. Faulkner
Publikováno v:
Cell Reports, Vol 23, Iss 13, Pp 3730-3740 (2018)
Summary: LINE-1 (L1) retrotransposons are a source of insertional mutagenesis in tumor cells. However, the clinical significance of L1 mobilization during tumorigenesis remains unclear. Here, we applied retrotransposon capture sequencing (RC-seq) to
Externí odkaz:
https://doaj.org/article/02b2c6ba831b4bec8988f6149861dbe1
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5625 (2021)
L1 transposons occupy 17% of the human genome and are widely exapted for the regulation of human genes, particularly in breast cancer, where we have previously shown abundant cancer-specific transcription factor (TF) binding sites within the L1PA2 su
Externí odkaz:
https://doaj.org/article/b00ae18f2ec54ab39744cd81bb49bbfc
Autor:
Sabine Klawitter, Nina V. Fuchs, Kyle R. Upton, Martin Muñoz-Lopez, Ruchi Shukla, Jichang Wang, Marta Garcia-Cañadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Sylvia Merkert, Patricia Gerdes, J. Andres Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Balázs Sarkadi, Johannes Löwer, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, Jose L. Garcia-Perez, Geoffrey J. Faulkner, Gerald G. Schumann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Genetic and epigenetic abnormalities have been found to result from reprogramming of differentiated cells into human induced pluripotent stem cells (hiPSCs). Here, Klawitter et al.identify endogenous L1, Alu and SVA mobilization during reprogramming,
Externí odkaz:
https://doaj.org/article/c3ef18eb5c21445d985ad18b9ff23d87
Autor:
Monique I. J. Spronken, Anjana C. Karawita, Alexander A. Khromykh, Keng Yih Chew, Cassandra L. Pegg, Lauren E. Steele, Kirsty R. Short, Myrna J. M. Bunte, Simon Phipps, Yin Xiang Setoh, Nathalie A. J. Verzele, Katina D. Hulme, Kyle R. Upton, Helle Bielefeldt-Ohmann, Conor J. Bloxham, Silvie Van den Hoecke, Bram Vrancken, Maria B. Sukkar
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife, 10:e61803, 1-21. eLife Sciences Publications
eLife
eLife, 10:e61803, 1-21. eLife Sciences Publications
Influenza virus has a high mutation rate, such that within one host different viral variants can emerge. Evidence suggests that influenza virus variants are more prevalent in pregnant and/or obese individuals due to their impaired interferon response
Autor:
Sabine Klawitter, Nina V. Fuchs, Kyle R. Upton, Martin Muñoz-Lopez, Ruchi Shukla, Jichang Wang, Marta Garcia-Cañadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Sylvia Merkert, Patricia Gerdes, J. Andres Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Balázs Sarkadi, Johannes Löwer, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, Jose L. Garcia-Perez, Geoffrey J. Faulkner, Gerald G. Schumann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
This Article contains an error in the author affiliations. The correct affiliation for author Ruchi Shukla is ‘MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK’, an
Externí odkaz:
https://doaj.org/article/73f8a71f8e3443d1af99aa1de2e348c3
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5625, p 5625 (2021)
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5625, p 5625 (2021)
L1 transposons occupy 17% of the human genome and are widely exapted for the regulation of human genes, particularly in breast cancer, where we have previously shown abundant cancer-specific transcription factor (TF) binding sites within the L1PA2 su