Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kyle R Legate"'
Autor:
Julia Novotny, Sue Chandraratne, Tobias Weinberger, Vanessa Philippi, Konstantin Stark, Andreas Ehrlich, Joachim Pircher, Ildiko Konrad, Paul Oberdieck, Anna Titova, Qendresa Hoti, Irene Schubert, Kyle R Legate, Nicole Urtz, Michael Lorenz, Jaroslav Pelisek, Steffen Massberg, Marie-Luise von Brühl, Christian Schulz
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190728 (2018)
Medical treatment of arterial thrombosis is mainly directed against platelets and coagulation factors, and can lead to bleeding complications. Novel antithrombotic therapies targeting immune cells and neutrophil extracellular traps (NETs) are current
Externí odkaz:
https://doaj.org/article/ac169229bb36440e998c5c36e0cc1e4f
Publikováno v:
Molecular Microbiology
Staphylococcus aureus, a gram-positive pathogen, invades cells mainly in an integrin-dependent manner. As the activity or conformation of several integrin-associated proteins can be regulated by phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2 ), we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f31385428c42daac373b448f33ffad8
https://doi.org/10.1111/mmi.14807
https://doi.org/10.1111/mmi.14807
Autor:
Thomas Baumruker, David Ledieu, Lingli Zhang, Nicole Urtz, Irene Schubert, Josef Pfeilschifter, Verena Barocke, Johannes Beil, Faridun Rahimi, Marie-Luise von Bruehl, Andrea Huwiler, Michael Lorenz, Steffen Massberg, Mathias Orban, Andreas Billich, Florian Gaertner, Kyle R. Legate, Elke Persohn, Michael Mederos y Schnitzler, Christian Beerli, Sue Chandraratne
Publikováno v:
Circulation Research. 117:376-387
Rationale: Platelets are known to play a crucial role in hemostasis. Sphingosine kinases (Sphk) 1 and 2 catalyze the conversion of sphingosine to the bioactive metabolite sphingosine 1-phosphate (S1P). Although platelets are able to secrete S1P on ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4170149ce4a8c2a98856dd064aab18
https://doi.org/10.1161/circresaha.115.306901
https://doi.org/10.1161/circresaha.115.306901
Autor:
Alexandra Mazharian, Steffen Massberg, Michael Lorenz, Stephen P. Watson, Tobias Petzold, Florian Gaertner, Nicole Urtz, Lin Zhang, Kyle R. Legate
Publikováno v:
Blood
Human megakaryocytes (MKs) release trillions of platelets each day into the circulation to maintain normal homeostatic platelet levels. We have previously shown that extracellular sphingosine 1-phosphate (S1P) plays a key role in thrombopoiesis via i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593a1a657219fdd11416acf01d5c0251
Autor:
Elisabeth Angermeier, Lin Zhang, Steffen Massberg, Florian Gaertner, Robert Lukowski, Kyle R. Legate, Michael Lorenz, Franz Hofmann, Katrin Domes
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Objective— The purpose of this study was to investigate the influence of cGMP-dependent kinase I (cGKI) on platelet production. Approach and Results— We used hematology analyser to measure platelet counts in conventional cGKI-null mutants (cGKI L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134fe0f544fb9c962bd299ce65fd6a9b
Publikováno v:
Journal of Cell Science. 125:5636-5646
Summary Localized production of polyphosphoinositides is critical for their signaling function. To examine the biological relevance of specific pools of phosphatidylinositol 4,5-bisphosphate we compared the consequences of genetically ablating all is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a285566de2da4d572d070f111e9def97
https://doi.org/10.1242/jcs.102145
https://doi.org/10.1242/jcs.102145
Autor:
Barbara Walzog, Konstantin Stark, Kyle R. Legate, Ingrid Hepper, Selgai Haidari, Marie-Luise von Brühl, Florian Gärtner, Steffen Massberg, Alexander G. Khandoga, Robert Pless, Kirsten Lauber, Anca Tirniceriu, Michael Lorenz, Annekathrin Eckart
Publikováno v:
Nature Immunology
Coordinated navigation within tissues is essential for cells of the innate immune system to reach the sites of inflammatory processes, but the signals involved are incompletely understood. Here we demonstrate that NG2(+) pericytes controlled the patt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0db9020f011370dd88af6a6811b243
https://doi.org/10.1038/ni.2477
https://doi.org/10.1038/ni.2477
Autor:
Carsten Grashoff, Reinhard Fässler, Sara Zanivan, Matthias Mann, S. B. Azimifar, Ralph T. Böttcher, Marcus Krüger, Kyle R. Legate
Publikováno v:
Journal of Cell Science. 125:435-448
Integrin and receptor tyrosine kinase signalling networks cooperate to regulate various biological functions. The molecular details underlying the integration of both signalling networks remain largely uncharacterized. Here we identify a signalling m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97e57ee37eb89e7f816e53fa954c91c
https://doi.org/10.1242/jcs.091652
https://doi.org/10.1242/jcs.091652
Autor:
Ben Fabry, Navid Bonakdar, Reinhard Fässler, Roy Zent, Kyle R. Legate, David Boettiger, Seiichiro Takahashi
Publikováno v:
The EMBO Journal. 30:4539-4553
The 90-kDa isoform of the lipid kinase PIP kinase Type I γ (PIPKIγ) localizes to focal adhesions (FAs), where it provides a local source of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Although PtdIns(4,5)P2 regulates the function of seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa69d9948b8ab72726839a870ab041b1
https://doi.org/10.1038/emboj.2011.332
https://doi.org/10.1038/emboj.2011.332
PIPKIγ90 Negatively Regulates LFA-1–Mediated Adhesion and Activation in Antigen-Induced CD4+ T Cells
Publikováno v:
The Journal of Immunology. 185:4714-4723
T cell activation requires the formation and maintenance of stable interactions between T cells and APCs. The formation of stable T cell–APC contacts depends on the activation of the integrin LFA-1 (CD11aCD18). Several positive regulators of LFA-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56650c2564c96e6a5e050fe50e720476
https://doi.org/10.4049/jimmunol.1001445
https://doi.org/10.4049/jimmunol.1001445