Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Kyle R, Covington"'
Autor:
Sarah T. Arron, Ashley Wysong, Mary A. Hall, Christine N. Bailey, Kyle R. Covington, Sarah J. Kurley, Matthew S. Goldberg, Julia M. Kasprzak, Ally‐Khan Somani, Sherrif F. Ibrahim, David G. Brodland, Nathan J. Cleaver, Ian A. Maher, Yang Xia, Shlomo A. Koyfman, Jason G. Newman
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 7, Iss 1, Pp 135-144 (2022)
Abstract Objective Over 50% of newly diagnosed cutaneous squamous cell carcinoma (cSCC) lesions occur in the head and neck (cSCC‐HN), and metastasis to nodal basins in this region further complicates surgical and adjuvant treatment. The current stu
Externí odkaz:
https://doaj.org/article/d6cb5b0c60914e73b12b558eb7bd2bdd
Autor:
Sherri Borman, Jeff Wilkinson, Lauren Meldi-Sholl, Clare Johnson, Kelsey Carter, Kyle R. Covington, Alison L. Fitzgerald, Sarah J. Kurley, Aaron S. Farberg, Matthew S. Goldberg, Federico A. Monzon, Kristen Oelschlager, Robert W. Cook
Publikováno v:
Diagnostic Pathology, Vol 17, Iss 1, Pp 1-9 (2022)
Abstract Background To improve identification of patients with cutaneous squamous cell carcinoma (SCC) at high risk for metastatic disease, the DecisionDx-SCC assay, a prognostic 40-gene expression profile (40-GEP) test, was developed and validated.
Externí odkaz:
https://doaj.org/article/5dc0fd7c5db947d38a48484f283f51a2
Autor:
Jonathan S. Zager, Brian R. Gastman, Sancy Leachman, Rene C. Gonzalez, Martin D. Fleming, Laura K. Ferris, Jonhan Ho, Alexander R. Miller, Robert W. Cook, Kyle R. Covington, Kristen Meldi-Plasseraud, Brooke Middlebrook, Lewis H. Kaminester, Anthony Greisinger, Sarah I. Estrada, David M. Pariser, Lee D. Cranmer, Jane L. Messina, John T. Vetto, Jeffrey D. Wayne, Keith A. Delman, David H. Lawson, Pedram Gerami
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background The heterogeneous behavior of patients with melanoma makes prognostication challenging. To address this, a gene expression profile (GEP) test to predict metastatic risk was previously developed. This study evaluates the GEP’s pr
Externí odkaz:
https://doaj.org/article/51ad8d737b2d423ab145b5125b6bb24a
Autor:
Robert W. Cook, Brooke Middlebrook, Jeff Wilkinson, Kyle R. Covington, Kristen Oelschlager, Federico A. Monzon, John F. Stone
Publikováno v:
Diagnostic Pathology, Vol 13, Iss 1, Pp 1-8 (2018)
Abstract Background The DecisionDx-Melanoma test provides prognostic information for patients with cutaneous melanoma (CM). Using formalin-fixed paraffin-embedded primary tumor tissue, the RT-PCR-based test classifies patients into a low- (Class 1) o
Externí odkaz:
https://doaj.org/article/30b48c55ec324058a0a1e42655dcca7e
Autor:
Eddy C. Hsueh, James R. DeBloom, Jonathan Lee, Jeffrey J. Sussman, Kyle R. Covington, Brooke Middlebrook, Clare Johnson, Robert W. Cook, Craig L. Slingluff, Kelly M. McMasters
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-8 (2017)
Abstract Background A 31-gene expression profile (GEP) test that provides risk classification of cutaneous melanoma (CM) patients has been validated in several retrospective studies. The objective of the reported study was a prospective evaluation of
Externí odkaz:
https://doaj.org/article/73636748782a40a5b60fd2f667dbd546
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
Autor:
Farshad Farshidfar, Siyuan Zheng, Marie-Claude Gingras, Yulia Newton, Juliann Shih, A. Gordon Robertson, Toshinori Hinoue, Katherine A. Hoadley, Ewan A. Gibb, Jason Roszik, Kyle R. Covington, Chia-Chin Wu, Eve Shinbrot, Nicolas Stransky, Apurva Hegde, Ju Dong Yang, Ed Reznik, Sara Sadeghi, Chandra Sekhar Pedamallu, Akinyemi I. Ojesina, Julian M. Hess, J. Todd Auman, Suhn K. Rhie, Reanne Bowlby, Mitesh J. Borad, Andrew X. Zhu, Josh M. Stuart, Chris Sander, Rehan Akbani, Andrew D. Cherniack, Vikram Deshpande, Taofic Mounajjed, Wai Chin Foo, Michael S. Torbenson, David E. Kleiner, Peter W. Laird, David A. Wheeler, Autumn J. McRee, Oliver F. Bathe, Jesper B. Andersen, Nabeel Bardeesy, Lewis R. Roberts, Lawrence N. Kwong
Publikováno v:
Cell Reports, Vol 18, Iss 11, Pp 2780-2794 (2017)
Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer
Externí odkaz:
https://doaj.org/article/1d6e88c5fa4e40259f49eebb46d2032d
Autor:
Hiroyuki Aburatani, Tadatoshi Takayama, Genta Nagae, Tatsuhiro Shibata, David A. Wheeler, Masahiko Sugitani, Chad J. Creighton, Kyle R. Covington, Shumpei Ishikawa, Hiroto Katoh, Takanori Fujita, Shiro Fukuda, Hiroki Ueda, Akimasa Hayashi, Shingo Tsuji, Claire Renard-Guillet, Kenji Tatsuno, Shogo Yamamoto, Yutaka Midorikawa
Table S1 shows Clinical features. Table S2 shows Patient/sample information and NGS statistics. Table S3 shows Methylation status of CpG sites of WNT targets with CTNNB1 mutation. Table S4 shows Chromosomal aberrations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdff4215192e5d93d37f56f1e9bc81e
https://doi.org/10.1158/0008-5472.22426225
https://doi.org/10.1158/0008-5472.22426225
Autor:
Powel H. Brown, Ching C. Lau, Gordon B. Mills, Jenny C. Chang, Susan G. Hilsenbeck, C. Kent Osborne, Michelle I Savage, Suzanne A.W. Fuqua, Alejandro Contreras, Kyle R. Covington, Graham M. Poage, Anna Tsimelzon, Matthew D. Burstein
Table S11. 80 Gene Signature for NMF Cluster 1 (LAR). Table S12. 80 Gene Signature for NMF Cluster 2 (MES). Table S13. 80 Gene Signature for NMF Cluster 3 (BLIS). Table S14. 80 Gene Signature for NMF Cluster 4 (BLIA). Table S15. Assignment of Discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffafa23da4c3e339f1606983ec09878
https://doi.org/10.1158/1078-0432.22460255
https://doi.org/10.1158/1078-0432.22460255
Autor:
Hiroyuki Aburatani, Tadatoshi Takayama, Genta Nagae, Tatsuhiro Shibata, David A. Wheeler, Masahiko Sugitani, Chad J. Creighton, Kyle R. Covington, Shumpei Ishikawa, Hiroto Katoh, Takanori Fujita, Shiro Fukuda, Hiroki Ueda, Akimasa Hayashi, Shingo Tsuji, Claire Renard-Guillet, Kenji Tatsuno, Shogo Yamamoto, Yutaka Midorikawa
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c20ca7a67d916e8e01d34e3005fa2c
https://doi.org/10.1158/0008-5472.22426234
https://doi.org/10.1158/0008-5472.22426234
Autor:
Mitchell J. Frederick, David A. Wheeler, Jeffrey N. Myers, Randal S. Weber, Richard A. Gibbs, Adel K. El-Naggar, Gary L. Clayman, Carlos Caulin, Sahil Seth, Jianhua Zhang, Kyle R. Covington, Eve Shinbrot, Harshavardhan Doddapaneni, Donna M. Muzny, Jun Yu, Stephen Y. Lai, Michael T. Tetzlaff, Jonathan L. Curry, Kenneth Y. Tsai, Rami E. Saade, S. Andrew Peng, Jennifer A. Drummond, J. Jack Lee, Jane H. Zhou, Curtis R. Pickering
Purpose: Aggressive cutaneous squamous cell carcinoma (cSCC) is often a disfiguring and lethal disease. Very little is currently known about the mutations that drive aggressive cSCC.Experimental Design: Whole-exome sequencing was performed on 39 case
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d039a885b2a0a81d92958f14eed82e8
https://doi.org/10.1158/1078-0432.c.6523832.v1
https://doi.org/10.1158/1078-0432.c.6523832.v1