Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kyle P. Lillis"'
Autor:
Beth A. Costine-Bartell, Luis Martinez-Ramirez, Kieran Normoyle, Tawny Stinson, Kevin J. Staley, Kyle P. Lillis
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract A common point of failure in translation of preclinical neurological research to successful clinical trials comes in the giant leap from rodent models to humans. Non-human primates are phylogenetically close to humans, but cost and ethical c
Externí odkaz:
https://doaj.org/article/64c3f6ac5c2c440dbc03ef5e8ea7a0d5
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 77 (2024)
GABA, the primary inhibitory neurotransmitter, stimulates GABAA receptors (GABAARs) to increase the chloride conductance of the cytosolic membrane. The driving forces for membrane chloride currents are determined by the local differences between intr
Externí odkaz:
https://doaj.org/article/a68879ae5f58441d972bfa05f88743dc
Publikováno v:
Neurobiology of Disease, Vol 47, Iss 3, Pp 358-366 (2012)
Seizures are thought to originate from a failure of inhibition to quell hyperactive neural circuits, but the nature of this failure remains unknown. Here we combine high-speed two-photon imaging with electrophysiological recordings to directly evalua
Externí odkaz:
https://doaj.org/article/564afde97e5a46489068e01660403af7
Autor:
Lauren A. Lau, Kyle P. Lillis
Publikováno v:
Epilepsy Currents. 23:127-129
[Box: see text]
Autor:
Kyle P. Lillis
Publikováno v:
Epilepsy currents. 22(3)
Autor:
Kyle P. Lillis
Publikováno v:
Epilepsy currents. 22(6)
[Box: see text]
Publikováno v:
Brain
Seizure initiation is the least understood and most disabling element of epilepsy. Studies of ictogenesis require high speed recordings at cellular resolution in the area of seizure onset. However, in vivo seizure onset areas cannot be determined at
Autor:
Kyle P. Lillis
Publikováno v:
Cerebral Cortex (New York, NY)
Neocortical heterotopia consist of ectopic neuronal clusters that are frequently found in individuals with cognitive disability and epilepsy. However, their pathogenesis remains poorly understood due in part to a lack of tractable animal models. We h
The amplitude of ictal activity is a defining feature of epileptic seizures, but the determinants of this amplitude have not been studied. Pathological synchronization of neuronal activity is assumed to be the main driver of increased ictal amplitude
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b54b8957134bb9d8fe2709f0099ed04e
https://doi.org/10.1101/2022.07.08.499193
https://doi.org/10.1101/2022.07.08.499193
Autor:
Kyle P. Lillis
Publikováno v:
Epilepsy Currents