Výsledky vyhledávání - "Kyle P. Heim"

Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion

Autor: Yuhang Liu, Ye Che, Philip R. Dormitzer, Xinzhen Yang, Seungil Han, Kyle P. Heim, Xiaoyuan Chi, Xiayang Qiu

Publikováno v: Science Advances

Prefusion human cytomegalovirus glycoprotein B structure reveals the structural basis for membrane fusion.
Human cytomegalovirus (HCMV) causes congenital disease with long-term morbidity. HCMV glycoprotein B (gB) transitions irreversibly from a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5798c05f687fac7dcf40269a017b7405
http://europepmc.org/articles/PMC7935361

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An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1

Autor: Paula J. Crowley, Shweta Kailasan, L. Jeannine Brady, Joanna R. Long, Kyle P. Heim, Robert McKenna

Publikováno v: Proceedings of the National Academy of Sciences. 111:15746-15751

The cariogenic bacterium Streptococcus mutans uses adhesin P1 to adhere to tooth surfaces, extracellular matrix components, and other bacteria. A composite model of P1 based on partial crystal structures revealed an unusual complex architecture in wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193be6cb9dd7b97972c20ac770a3ce7d
https://doi.org/10.1073/pnas.1413018111

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Streptococcus mutans Extracellular DNA Is Upregulated during Growth in Biofilms, Actively Released via Membrane Vesicles, and Influenced by Components of the Protein Secretion Machinery

Autor: Zezhang T. Wen, Yuwei Fan, L. Jeannine Brady, Kyle P. Heim, San-Joon Ahn, Robert A. Burne, Jacob P. Bitoun, Sumei Liao, Marlise I. Klein, Hyun Koo

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2018-12-11T16:56:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-01-01 National Institutes of Health Streptococcus mutans, a major etiological agent of human dental caries, lives primarily on the tooth surface in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b916079ecb9efb792aff5c2e2eef244
https://doi.org/10.1128/jb.01493-14

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An Intramolecular Interaction Involving the N Terminus of a Streptococcal Adhesin Affects Its Conformation and Adhesive Function

Autor: Paula J. Crowley, Kyle P. Heim, L. Jeannine Brady

Publikováno v: Journal of Biological Chemistry. 288:13762-13774

P1 is an adhesin on the surface of Streptococcus mutans.Destroying the high affinity interaction between the N and C termini of S. mutans P1 creates a non-adherent phenotype.The N terminus facilitates proper folding, function, and stability within re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08904b5deb34782d21892f74fa6ac871
https://doi.org/10.1074/jbc.m113.459974

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Identification of a Supramolecular Functional Architecture of Streptococcus mutans Adhesin P1 on the Bacterial Cell Surface*

Autor: Paula J. Crowley, Audrey Beaussart, Yves F. Dufrêne, Richard N. Besingi, Wenxing Tang, Sofiane El-Kirat-Chatel, Ruby May A. Sullan, Kyle P. Heim, L. Jeannine Brady

P1 (antigen I/II) is a sucrose-independent adhesin of Streptococcus mutans whose functional architecture on the cell surface is not fully understood. S. mutans cells subjected to mechanical extraction were significantly diminished in adherence to imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2974cc40a191d4743a31f8870ec6a00
https://europepmc.org/articles/PMC4423689/

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Alterations in immunodominance of Streptococcus mutans AgI/II: lessons learned from immunomodulatory antibodies

Autor: Monika W. Oli, William P. McArthur, Paula J. Crowley, Kyle P. Heim, L. Jeannine Brady, Rebekah A. Robinette

Publikováno v: Vaccine. 32(3)

Streptococcus mutans antigen I/II (AgI/II) has been widely studied as a candidate vaccine antigen against human dental caries. In this report we follow up on prior studies that indicated that anti-AgI/II immunomodulatory monoclonal antibodies (MAbs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b98e6b335dca943b75a57c857d5a62
https://pubmed.ncbi.nlm.nih.gov/24252705

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Functional amyloid formation by Streptococcus mutans

Autor: H. N. Otoo, Kyle P. Heim, Paula J. Crowley, Monika W. Oli, Caleen B. Ramsook, Peter N. Lipke, L. J. Brady, Marcelle M. Nascimento

Publikováno v: Microbiology (Reading, England). 158(Pt 12)

Dental caries is a common infectious disease associated with acidogenic and aciduric bacteria, including Streptococcus mutans. Organisms that cause cavities form recalcitrant biofilms, generate acids from dietary sugars and tolerate acid end products

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62bb71ed3144b12c1ef33cd63ebac1b
https://pubmed.ncbi.nlm.nih.gov/23082034

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Straw blood cell count, growth, inhibition and comparison to apoptotic bodies

Autor: Yonnie Wu, David C Henry, Kyle P. Heim, Cheng-Yi Kuan, Jeffrey P. Tomkins

Publikováno v: BMC Cell Biology
BMC Cell Biology, Vol 9, Iss 1, p 26 (2008)

Background Mammalian cells transform into individual tubular straw cells naturally in tissues and in response to desiccation related stress in vitro. The transformation event is characterized by a dramatic cellular deformation process which includes:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf41af1d693b08ffa6e758ca3f4b5af
http://europepmc.org/articles/PMC2397387

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