Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kyle P. Eagen"'
Autor:
Celestia Fang, Zhenjia Wang, Cuijuan Han, Stephanie L. Safgren, Kathryn A. Helmin, Emmalee R. Adelman, Valentina Serafin, Giuseppe Basso, Kyle P. Eagen, Alexandre Gaspar-Maia, Maria E. Figueroa, Benjamin D. Singer, Aakrosh Ratan, Panagiotis Ntziachristos, Chongzhi Zang
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-30 (2020)
Abstract Background The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding
Externí odkaz:
https://doaj.org/article/201a149ebc41420fb2d70ed374836a5e
Autor:
Kyle P, Eagen
Publikováno v:
Nature genetics. 54(4)
Autor:
Alexander S. Lee, Ali Shilatifard, Daniel R. Foltz, Kyle P. Eagen, Justin Bodner, Alexander B. Willis, Celeste Rosencrance, Matthew N Gaynes, Ann K. Hogan, Shashank Srivastava, Aaron O. Bailey, Marc A. Morgan, Kizhakke M Sathyan, Jiehuan Huang, Sakshi Khurana, Ewelina Zasadzinska, Kelvin A. Wong
Publikováno v:
EMBO J
Histone chaperones modulate the stability of histones beginning from histone synthesis, through incorporation into DNA, and during recycling during transcription and replication. Following histone removal from DNA, chaperones regulate histone storage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e9d40f5b40ef33fee5c10f98b83950
https://europepmc.org/articles/PMC8672181/
https://europepmc.org/articles/PMC8672181/
Autor:
Christopher A. French, Kyle P. Eagen
Publikováno v:
Oncogene
NUT carcinoma (NC) is an extremely aggressive squamous cancer with no effective therapy. NC is driven, most commonly, by the BRD4-NUT fusion oncoprotein. BRD4-NUT combines the chromatin-binding bromo- and extraterminal domain-containing (BET) protein
Autor:
Alexandre Gaspar-Maia, Emmalee R. Adelman, Kyle P. Eagen, Benjamin D. Singer, Cuijuan Han, Valentina Serafin, Kathryn A. Helmin, Chongzhi Zang, Stephanie L. Safgren, Celestia Fang, Aakrosh Ratan, Zhenjia Wang, Maria E. Figueroa, Panagiotis Ntziachristos, Giuseppe Basso
Publikováno v:
Genome Biology
GENOME BIOLOGY
Genome Biology, Vol 21, Iss 1, Pp 1-30 (2020)
GENOME BIOLOGY
Genome Biology, Vol 21, Iss 1, Pp 1-30 (2020)
Background The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding protein w
Autor:
Stephanie L. Safgren, Emmalee R. Adelman, Alexandre Gaspar-Maia, Aakrosh Ratan, Cuijuan Han, Zhenjia Wang, Maria E. Figueroa, Chongzhi Zang, Benjamin D. Singer, Kyle P. Eagen, Kathryn A. Helmin, Panagiotis Ntziachristos, Celestia Fang
BackgroundThe three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding protein wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565d9c1b4db535eb59bbaf74f25d2b7b
Publikováno v:
Trends Biochem Sci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b43d1ae5d93edf54f31035a7865f34e
https://europepmc.org/articles/PMC7105279/
https://europepmc.org/articles/PMC7105279/
Publikováno v:
Cell. 163(4):934-946
SummaryChemical cross-linking and DNA sequencing have revealed regions of intra-chromosomal interaction, referred to as topologically associating domains (TADs), interspersed with regions of little or no interaction, in interphase nuclei. We find tha
Autor:
Emily J. Rendleman, Celeste Rosencrance, Haneen N. Ammouri, Tiffany Ge, Kyle P. Eagen, Stacy A. Marshall, Qi Yu
Publikováno v:
Mol Cell
Delineating how chromosomes fold at length scales beyond one megabase remains obscure relative to smaller-scale folding into TADs, loops, and nucleosomes. We find that rather than simply unfolding chromatin, histone hyperacetylation results in intera
Autor:
Kyle P. Eagen
Publikováno v:
Trends in biochemical sciences. 43(6)
Chromosomes are folded and compacted within interphase nuclei, but the molecular basis of this folding is poorly understood. Chromosome conformation capture methods, such as Hi-C, combine chemical cross-linking of chromatin followed by fragmentation,