Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kyle N. Klein"'
Autor:
Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N. Klein, Mariia Nazarova, Ursula E. Schoeberl, David M. Gilbert, Sara C. B. Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. He
Externí odkaz:
https://doaj.org/article/7e8a67d729464111a78e5ef9b1dc0236
Autor:
Stefano Gnan, Ilya M. Flyamer, Kyle N. Klein, Eleonora Castelli, Alexander Rapp, Andreas Maiser, Naiming Chen, Patrick Weber, Elin Enervald, M. Cristina Cardoso, Wendy A. Bickmore, David M. Gilbert, Sara C. B. Buonomo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
How nuclear architecture overall affects the replication-timing programme is not yet clear. Here the authors reveal RIF1’s dual role as a chromatin-interaction scaffold and regulator of replication timing that allows the coordination of these two a
Externí odkaz:
https://doaj.org/article/051ec9ea54774968bffcfc289db433ad
Autor:
Marion Cremer, Katharina Brandstetter, Andreas Maiser, Suhas S. P. Rao, Volker J. Schmid, Miguel Guirao-Ortiz, Namita Mitra, Stefania Mamberti, Kyle N. Klein, David M. Gilbert, Heinrich Leonhardt, M. Cristina Cardoso, Erez Lieberman Aiden, Hartmann Harz, Thomas Cremer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The role of cohesin in organizing a functional nuclear architecture remains poorly understood. Here the authors show that cohesin depleted cells pass through endomitosis forming a multilobulated nucleus able to proceed through S-phase with typical fe
Externí odkaz:
https://doaj.org/article/f0e404681d714c6f838a9676235998d2
Autor:
Juan Carlos Rivera-Mulia, Takayo Sasaki, Claudia Trevilla-Garcia, Naoto Nakamichi, David J. H.F. Knapp, Colin A. Hammond, Bill H. Chang, Jeffrey W. Tyner, Meenakshi Devidas, Jared Zimmerman, Kyle N. Klein, Vivek Somasundaram, Brian J. Druker, Tanja A. Gruber, Amnon Koren, Connie J. Eaves, David M. Gilbert
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3201-3213 (2019)
Abstract: Human B-cell precursor acute lymphoid leukemias (BCP-ALLs) comprise a group of genetically and clinically distinct disease entities with features of differentiation arrest at known stages of normal B-lineage differentiation. We previously s
Externí odkaz:
https://doaj.org/article/813e5445336443a09e50cbf90d7c35a2
Autor:
Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N. Klein, Mariia Nazarova, Ursula E. Schoeberl, David M. Gilbert, Sara C. B. Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri
The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ca2f9f2410fc9104796be93eee4e079
https://doi.org/10.1101/2023.03.31.535086
https://doi.org/10.1101/2023.03.31.535086
Autor:
David M. Gilbert, Shin-ichiro Hiraga, Toyoaki Natsume, Danny Leung, Ipek Tasan, Xuemeng Zhou, Anne D. Donaldson, Meng Zhang, Daniel A. Bartlett, Xiaowen Lyu, Takayo Sasaki, Timour Baslan, Amar M. Singh, Victor G. Corces, Masato T. Kanemaki, Lotte P. Watts, Kyle N. Klein, Stephen Dalton, Huimin Zhao, Peiyao A. Zhao
Publikováno v:
Science
Replication timing organizes epigenome The temporal order of DNA replication is conserved from yeast to humans, but its biological significance remains unclear. Klein et al. eliminated the protein RIF1, a master regulator of replication timing, in se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b4e2880380bab43282277f04c7f32f
https://doi.org/10.1126/science.aba5545
https://doi.org/10.1126/science.aba5545
Publikováno v:
Proc IEEE Int Symp Biomed Imaging
ISBI
ISBI
This paper develops statistical tools for testing differences in shapes of chromosomes resulting from certain gene knockouts (KO), specifically RIF1 gene KO (RKO) and the cohesin subunit RAD21 gene KO (CKO). It utilizes a two-sample test for comparin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e74ed681348fc360baf56c0499eb574
https://pubmed.ncbi.nlm.nih.gov/35165532
https://pubmed.ncbi.nlm.nih.gov/35165532
Autor:
Alexander Rapp, Wendy A. Bickmore, David M. Gilbert, Ilya M. Flyamer, Patrick Weber, M. Cristina Cardoso, Naiming Chen, Eleonora Castelli, Stefano Gnan, Elin Enervald, Sara C. B. Buonomo, Andreas Maiser, Kyle N. Klein
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2910. ⟨10.1038/s41467-021-22899-2⟩
bioRxiv
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Gnan, S, Flyamer, I M, Klein, K N, Castelli, E, Rapp, A, Maiser, A, Chen, N, Weber, P, Enervald, E, Cardoso, C, Bickmore, W A, Gilbert, D M & Buonomo, S B C 2021, ' Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction ', Nature Communications . https://doi.org/10.1038/s41467-021-22899-2
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2910. ⟨10.1038/s41467-021-22899-2⟩
bioRxiv
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Gnan, S, Flyamer, I M, Klein, K N, Castelli, E, Rapp, A, Maiser, A, Chen, N, Weber, P, Enervald, E, Cardoso, C, Bickmore, W A, Gilbert, D M & Buonomo, S B C 2021, ' Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction ', Nature Communications . https://doi.org/10.1038/s41467-021-22899-2
Three-dimensional genome organisation and replication timing are known to be correlated, however, it remains unknown whether nuclear architecture overall plays an instructive role in the replication-timing programme and, if so, how. Here we demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43cedcd7184b8613c7bfc8e3f2e1f34
https://doi.org/10.1038/s41467-021-22899-2
https://doi.org/10.1038/s41467-021-22899-2
Autor:
Job Dekker, Jennifer E. Phillips-Cremins, Takayo Sasaki, David M. Gilbert, Johan H. Gibcus, Daniel J. Emerson, Sergey V Venvev, Liyan Yang, Linda Zhou, Kyle N. Klein, Peiyao A. Zhao, Chunmin Ge
DNA replication occurs through an intricately regulated series of molecular events and is fundamental for genome stability across dividing cells in metazoans. It is currently unknown how the location of replication origins and the timing of their act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f402fe03f24009d4f163c8e2f44fa58c
https://doi.org/10.1101/2021.01.05.425437
https://doi.org/10.1101/2021.01.05.425437
Autor:
Daniel J. Emerson, Peiyao A. Zhao, Ashley L. Cook, R. Jordan Barnett, Kyle N. Klein, Dalila Saulebekova, Chunmin Ge, Linda Zhou, Zoltan Simandi, Miriam K. Minsk, Katelyn R. Titus, Weitao Wang, Wanfeng Gong, Di Zhang, Liyan Yang, Sergey V. Venev, Johan H. Gibcus, Hongbo Yang, Takayo Sasaki, Masato T. Kanemaki, Feng Yue, Job Dekker, Chun-Long Chen, David M. Gilbert, Jennifer E. Phillips-Cremins
Publikováno v:
Nature. 606(7915)
DNA replication occurs through an intricately regulated series of molecular events and is fundamental for genome stability1,2. At present, it is unknown how the locations of replication origins are determined in the human genome. Here we dissect the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd24f7ab9499fb37e47d80273457909
https://pubmed.ncbi.nlm.nih.gov/35676475
https://pubmed.ncbi.nlm.nih.gov/35676475