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Rigidified Scaffolds for 3 Angstrom Resolution Cryo-EM of Small Therapeutic Protein Targets

Autor: Roger Castells-Graells, Kyle Meador, Mark A. Arbing, Michael R. Sawaya, Morgan Gee, Duilio Cascio, Emma Gleave, Judit É. Debreczeni, Jason Breed, Chris Phillips, Todd O. Yeates

Numerous technical advances have made cryo-EM an attractive method for atomic structure determination. Cryo-EM is ideally suited for large macromolecular structures, while problems of low signal-to-noise prevent routine structure determination of pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66a660e313b807d2de9725cea7726274
https://doi.org/10.1101/2022.09.18.508009

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Novel designed rigidified imaging scaffolds for high-resolution structure determination of small proteins with cryo-EM

Autor: Roger Castells Graells, Kyle Meador, Morgan Gee, Todd Yeates, Kevin Cannon

Publikováno v: Acta Crystallographica Section A Foundations and Advances. 78:a43-a43

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e5eff9027749bbc20cce12e3ca9c91f
https://doi.org/10.1107/s2053273322099569

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A fragment-based protein interface design algorithm for symmetric assemblies

Autor: Kyle Meador, Joshua Laniado, Todd O. Yeates

Publikováno v: Protein Eng Des Sel

Theoretical and experimental advances in protein engineering have led to the creation of precisely defined, novel protein assemblies of great size and complexity, with diverse applications. One powerful approach involves designing a new attachment or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa8d91fc4b26f17f1c8ac63c7708711
https://doi.org/10.1093/protein/gzab008

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Achieving tight control of a photoactivatable Cre recombinase gene switch: new design strategies and functional characterization in mammalian cells and rodent

Autor: Aaron J. Norris, Michael R. Bruchas, Christina L. Wysoczynski, Jason Aoto, Chandra L. Tucker, Kyle Meador

Publikováno v: Nucleic Acids Research

A common mechanism for inducibly controlling protein function relies on reconstitution of split protein fragments using chemical or light-induced dimerization domains. A protein is split into fragments that are inactive on their own, but can be recon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd000e38b256250396b713875c0e718
https://pubmed.ncbi.nlm.nih.gov/31287871

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