Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kyle Mangano"'
Autor:
Irina Laczkovich, Kyle Mangano, Xinhao Shao, Adam J. Hockenberry, Yu Gao, Alexander Mankin, Nora Vázquez-Laslop, Michael J. Federle
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Streptococcus pneumoniae, an opportunistic human pathogen, is the leading cause of community-acquired pneumonia and an agent of otitis media, septicemia, and meningitis. Although genomic and transcriptomic studies of S. pneumoniae have provi
Externí odkaz:
https://doaj.org/article/f4394a0dfc874f73a61901fee1d4e8a3
Autor:
Kyle Mangano, Tanja Florin, Xinhao Shao, Dorota Klepacki, Irina Chelysheva, Zoya Ignatova, Yu Gao, Alexander S Mankin, Nora Vázquez-Laslop
Publikováno v:
eLife, Vol 9 (2020)
Biochemical studies suggested that the antimicrobial peptide apidaecin (Api) inhibits protein synthesis by binding in the nascent peptide exit tunnel and trapping the release factor associated with a terminating ribosome. The mode of Api action in ba
Externí odkaz:
https://doaj.org/article/9e38722b3a344e0cacd910a2f28a93ea
Autor:
Tejabhiram Yadavalli, Alex Agelidis, Dinesh Jaishankar, Kyle Mangano, Neel Thakkar, Kumar Penmetcha, Deepak Shukla
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 365-378 (2017)
Herpes simplex virus type 1 (HSV-1) is an important factor for vision loss in developed countries. A challenging aspect of the ocular infection by HSV-1 is that common treatments, such as acyclovir, fail to provide effective topical remedies. Further
Externí odkaz:
https://doaj.org/article/089153b261db4d7991b3706f4878e1f3
Autor:
Kyle Mangano, Dorota Klepacki, Irueosa Ohanmu, Chetana Baliga, Weiping Huang, Alexandra Brakel, Andor Krizsan, Yury S. Polikanov, Ralf Hoffmann, Nora Vázquez-Laslop, Alexander S. Mankin
Publikováno v:
Nature Chemical Biology.
Autor:
Kyle Mangano, Dorota Klepacki, Irueosa Ohanmu, Chetana Baliga, Weiping Huang, Alexandra Brakel, Andor Krizsan, Yury S. Polikanov, Ralf Hoffmann, Nora Vázquez-Laslop, Alexander S. Mankin
A 19-amino acid longproline-richantimicrobialpeptide (PrAMP) Drosocin (Dro) is encoded in the fruit fly genome. Native Dro is glycosylated at a specific threonine residue, but the non-glycosylated peptide retains antibacterial activity. Dro shows seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23e1826b5db325540da9da3fd6046f5
https://doi.org/10.1101/2022.12.11.519952
https://doi.org/10.1101/2022.12.11.519952
Autor:
Kyle Mangano, James Marks, Dorota Klepacki, Chayan Kumar Saha, Gemma C. Atkinson, Nora Vázquez-Laslop, Alexander S. Mankin
Publikováno v:
Nature chemical biology. 18(11)
Orthosomycin antibiotics inhibit protein synthesis by binding to the large ribosomal subunit in the tRNA accommodation corridor, which is traversed by incoming aminoacyl-tRNAs. Structural and biochemical studies suggested that orthosomycins block acc
Publikováno v:
J Bacteriol
Small proteins of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e07848b5007bad44262938f4c1cced
https://europepmc.org/articles/PMC8765432/
https://europepmc.org/articles/PMC8765432/
Small proteins of Escherichia coli cells treated with antibiotics that stall ribosomes at either start or stop codons. Thus, we identify ribosome-occupied start and stop codons for ~400 novel putative ORFs with high sensitivity. The newly discovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7b7f57d6e0066935d1e662781d74598
https://doi.org/10.1101/2021.07.02.450978
https://doi.org/10.1101/2021.07.02.450978
Autor:
Yu Gao, Alexander S. Mankin, Dorota Klepacki, Kyle Mangano, Nora Vázquez-Laslop, Irina Chelysheva, Zoya Ignatova, Tanja Florin, Xinhao Shao
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Biochemical studies suggested that the antimicrobial peptide apidaecin (Api) inhibits protein synthesis by binding in the nascent peptide exit tunnel and trapping the release factor associated with a terminating ribosome. The mode of Api action in ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f763f700e6b9e6f65f35f4ad0c58ff4
Autor:
Zoya Ignatova, Yu Gao, Irina Chelysheva, Nora Vázquez-Laslop, Dorota Klepacki, Alexander S. Mankin, Tanja Florin, Xinhao Shao, Kyle Mangano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7608ad9b8d9e90ee156c360e91f5019e
https://doi.org/10.7554/elife.62655.sa2
https://doi.org/10.7554/elife.62655.sa2