Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Kyle Malone"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-13 (2024)
Abstract Smac mimetic compounds (SMCs) are small molecule drugs that sensitize cancer cells to TNF-α-induced cell death and have multiple immunostimulatory effects through alterations in NF-κB signaling. The combination of SMCs with immunotherapies
Externí odkaz:
https://doaj.org/article/e7dfa93325ff4ad39a2ad7f101b6277c
Autor:
Huy-Dung Hoang, Aida Said, Nasana Vaidya, Victoria H Gilchrist, Kyle Malone, Usha Kabilan, Serena Topshee, Xiao Xiang, An-Dao Yang, David Olagnier, Karen Mossman, Shawn T Beug, Seyed Mehdi Jafarnejad, Samuel T Workenhe, Tyson E Graber, Tommy Alain
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background Transgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection, com
Externí odkaz:
https://doaj.org/article/a6f957f1406d4b8b8ac61e2d28561a27
Publikováno v:
Cells, Vol 12, Iss 20, p 2508 (2023)
Adult stem cells (ASCs) can be cultured with difficulty from most tissues, often requiring chemical or transgenic modification to achieve adequate quantities. We show here that mouse primary fibroblasts, grown in suspension, change from the elongated
Externí odkaz:
https://doaj.org/article/f604cad77eec4beabedfb4f84dcd0566
Autor:
Kyle Malone, Jennifer A. Shearer, John M. Williams, Anne C. Moore, Tom Moore, Christian Waeber
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 25, Iss , Pp 100497- (2022)
Background: The well-characterised role of the immune system in acute ischaemic stroke has prompted the search for immunomodulatory therapies. Pregnancy-specific glycoproteins (PSGs) are a group of proteins synthesised by placental trophoblasts which
Externí odkaz:
https://doaj.org/article/3cbd3c0371184b83ab73e99729480390
Autor:
Sylvie Amu, Kyle Malone
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 8, Pp 1748-1750 (2022)
Externí odkaz:
https://doaj.org/article/3d7ff375dd2842eabcaf2842f4c578e3
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Preclinical data indicate that fingolimod improves outcome post-ischaemia. This study used a rigorous study design in normal male C57BL/6JOlaHsd mice and in mice with common stroke comorbidities to further evaluate the translational potential of fing
Externí odkaz:
https://doaj.org/article/0d1d805d8434447cbd500d93505cc85a
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background The role of the immune system in stroke is well-recognised. Fingolimod, an immunomodulatory agent licensed for the management of relapsing-remitting multiple sclerosis, has been shown to provide benefit in rodent models of stroke.
Externí odkaz:
https://doaj.org/article/c3d6e76d3dd84ba7955ad30aeeca0ca9
Publikováno v:
Data in Brief, Vol 36, Iss , Pp 107146- (2021)
In this work, the sphingosine-1-phosphate receptor modulator fingolimod was assessed as a preclinical candidate for the treatment of acute ischaemic stroke according to the Stroke Therapy Academic Industry Roundtable (STAIR) preclinical recommendatio
Externí odkaz:
https://doaj.org/article/e5f9291e44d74355923e1a6f482c28c4
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Intracerebral haemorrhage (ICH) has no specific treatment, but accounts for up to 15% of all strokes and has the highest mortality. Fingolimod (FTY720) is an immunomodulator approved for the management of multiple sclerosis, with abundant evidence of
Externí odkaz:
https://doaj.org/article/279c416a16a24ba7a79ffbfce60ab8c5
Publikováno v:
Cells, Vol 10, Iss 10, p 2672 (2021)
Autophagy is a fundamental catabolic process essential for the maintenance of cellular and tissue homeostasis, as well as directly contributing to the control of invading pathogens. Unsurprisingly, this process becomes critical in supporting cellular
Externí odkaz:
https://doaj.org/article/999b098f42c74916b8d776825eba77e9