Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Kyle M. Loh"'
Autor:
Sivakamasundari Vijayakumar, Roberta Sala, Gugene Kang, Angela Chen, Michelle Ann Pablo, Abidemi Ismail Adebayo, Andrea Cipriano, Jonas L. Fowler, Danielle L. Gomes, Lay Teng Ang, Kyle M. Loh, Vittorio Sebastiano
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Generating primordial germ cell-like cells (PGCLCs) from human pluripotent stem cells (hPSCs) advances studies of human reproduction and development of infertility treatments, but often entails complex 3D aggregates. Here we develop a simpli
Externí odkaz:
https://doaj.org/article/8e8d0192fda64084872f8d3b27e40339
Autor:
Parisha P. Shah, Kathleen C. Keough, Ketrin Gjoni, Garrett T. Santini, Richard J. Abdill, Nadeera M. Wickramasinghe, Carolyn E. Dundes, Ashley Karnay, Angela Chen, Rachel E. A. Salomon, Patrick J. Walsh, Son C. Nguyen, Sean Whalen, Eric F. Joyce, Kyle M. Loh, Nicole Dubois, Katherine S. Pollard, Rajan Jain
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-35 (2023)
Abstract Background Association of chromatin with lamin proteins at the nuclear periphery has emerged as a potential mechanism to coordinate cell type-specific gene expression and maintain cellular identity via gene silencing. Unlike many histone mod
Externí odkaz:
https://doaj.org/article/3460c0bf62da40d5bb6ad6b6c60d65c4
Autor:
Naomi R. Genuth, Zhen Shi, Koshi Kunimoto, Victoria Hung, Adele F. Xu, Craig H. Kerr, Gerald C. Tiu, Juan A. Oses-Prieto, Rachel E. A. Salomon-Shulman, Jeffrey D. Axelrod, Alma L. Burlingame, Kyle M. Loh, Maria Barna
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How ribosomes differ in composition and function to regulate gene expression is poorly understood. Here, the authors show that ribosome composition changes during stem cell differentiation and identify a ribosomal protein that regulates production of
Externí odkaz:
https://doaj.org/article/a6cf4298de7147c5aaf405ad37df4aa1
Autor:
Renata M. Martin, Jonas L. Fowler, M. Kyle Cromer, Benjamin J. Lesch, Ezequiel Ponce, Nobuko Uchida, Toshinobu Nishimura, Matthew H. Porteus, Kyle M. Loh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Human pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types.
Externí odkaz:
https://doaj.org/article/1bf355be0de745bc987455ce3536745a
Autor:
Lay Teng Ang, Antson Kiat Yee Tan, Matias I. Autio, Su Hua Goh, Siew Hua Choo, Kian Leong Lee, Jianmin Tan, Bangfen Pan, Jane Jia Hui Lee, Jen Jen Lum, Christina Ying Yan Lim, Isabelle Kai Xin Yeo, Chloe Jin Yee Wong, Min Liu, Jueween Ling Li Oh, Cheryl Pei Lynn Chia, Chet Hong Loh, Angela Chen, Qingfeng Chen, Irving L. Weissman, Kyle M. Loh, Bing Lim
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 2190-2205 (2018)
Summary: How are closely related lineages, including liver, pancreas, and intestines, diversified from a common endodermal origin? Here, we apply principles learned from developmental biology to rapidly reconstitute liver progenitors from human pluri
Externí odkaz:
https://doaj.org/article/18dfda95bb854672b8638aaa6e3a3810
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 301-307 (2017)
Summary: How do stem cells respond to signals to initiate differentiation? Here, we show that, despite uniform exposure to differentiation-inducing extracellular signals, individual human embryonic stem cells (hESCs) respond heterogeneously. To track
Externí odkaz:
https://doaj.org/article/c34057cb35c64d488fc914cb62c0a773
Autor:
Hui Cheng, Heather Yin-Kuan Ang, Chadi A. EL Farran, Pin Li, Hai Tong Fang, Tong Ming Liu, Say Li Kong, Michael Lingzi Chin, Wei Yin Ling, Edwin Kok Hao Lim, Hu Li, Tara Huber, Kyle M. Loh, Yuin-Han Loh, Bing Lim
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Direct reprogramming of closely-related lineages can generate hematopoietic stem cells. Here, the authors show hematopoietic transcription factors Scl, Lmo2, Runx1 and Bmi1 can reprogram fibroblasts into induced hematopoietic progenitors (iHPs), whic
Externí odkaz:
https://doaj.org/article/7d2ce78d316b47009ea53ac3b86aacc1
Autor:
David Gonzalez-Perez, Satyajit Das, Daniel Antfolk, Hadia S. Ahsan, Elliot Medina, Carolyn E. Dundes, Rayyan T. Jokhai, Emily D. Egan, Stephen C. Blacklow, Kyle M. Loh, Paulo C. Rodriguez, Vincent C. Luca
Publikováno v:
Nature Chemical Biology. 19:9-17
Autor:
Parisha P. Shah, Kathleen C. Keough, Ketrin Gjoni, Garrett T. Santini, Richard J. Abdill, Nadeera M. Wickramasinghe, Carolyn E. Dundes, Ashley Karnay, Angela Chen, Rachel E. A. Salomon, Patrick J. Walsh, Son C. Nguyen, Sean Whalen, Eric F. Joyce, Kyle M. Loh, Nicole Dubois, Katherine S. Pollard, Rajan Jain
Background Association of chromatin with lamin proteins at the nuclear periphery has emerged as a potential mechanism to coordinate cell type-specific gene expression and maintain cellular identity via gene silencing. Unlike many histone modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6d030dec7f1dbac43e8a790e0a54b9
Autor:
Alana Nguyen, Karen M. Gonzalez, Yue Zhang, Kristy Red-Horse, Brian C. Raftrey, Robert Roth, Andrew H. Chang, Mingming Zhao, Xiaochen Fan, Ian M. Williams, Lay Teng Ang, Pamela E. Rios Coronado, Kyle M. Loh, Ragini Phansalkar, Timothy Chai, Gaetano D'Amato, Emily Trimm, Daniel Bernstein, Raquel Racelis
Publikováno v:
Circulation research. 129(7)
Rationale: Coronary artery disease is the leading cause of death worldwide, but there are currently no methods to stimulate artery growth or regeneration in diseased hearts. Studying how arteries are built during development could illuminate strategi