Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Kyle M. Kovary"'
1
Akademický článek
Molecular Competition in G1 Controls When Cells Simultaneously Commit to Terminally Differentiate and Exit the Cell Cycle
Autor: Michael L. Zhao, Atefeh Rabiee, Kyle M. Kovary, Zahra Bahrami-Nejad, Brooks Taylor, Mary N. Teruel
Publikováno v: Cell Reports, Vol 31, Iss 11, Pp 107769- (2020)
Summary: Terminal differentiation is essential for the development and maintenance of tissues in all multi-cellular organisms and is associated with permanent exit from the cell cycle. Failure to permanently exit the cell cycle can result in cancer a
Externí odkaz: https://doaj.org/article/59fb54205e6c48ada864e56e7e113c29
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2
Akademický článek
Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice
Autor: Asuka Ota, Kyle M. Kovary, Olivia H. Wu, Robert Ahrends, Wen-Jun Shen, Maria J. Costa, Brian J. Feldman, Fredric B. Kraemer, Mary N. Teruel
Publikováno v: Journal of Lipid Research, Vol 56, Iss 5, Pp 1068-1078 (2015)
Insulin resistance (IR) underlies metabolic disease. Visceral, but not subcutaneous, white adipose tissue (WAT) has been linked to the development of IR, potentially due to differences in regulatory protein abundance. Here we investigate how protein
Externí odkaz: https://doaj.org/article/203c56a49c8a4714a6027c0f4222f5d6
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3
Akademický článek
Expression variation and covariation impair analog and enable binary signaling control
Autor: Kyle M Kovary, Brooks Taylor, Michael L Zhao, Mary N Teruel
Publikováno v: Molecular Systems Biology, Vol 14, Iss 5, Pp 1-21 (2018)
Abstract Due to noise in the synthesis and degradation of proteins, the concentrations of individual vertebrate signaling proteins were estimated to vary with a coefficient of variation (CV) of approximately 25% between cells. Such high variation is
Externí odkaz: https://doaj.org/article/f83ec445d2ac46a4a02ee95684c0b9d9
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5
Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy
Autor: Stefan Tholen, Roma Patel, Agnieszka Agas, Kyle M. Kovary, Atefeh Rabiee, Hayley T. Nicholls, Ewa Bielczyk-Maczyńska, Wenting Yang, Fredric B. Kraemer, Mary N. Teruel
Publikováno v: Cell Rep
Disruption of circadian glucocorticoid oscillations in Cushing's disease and chronic stress results in obesity and adipocyte hypertrophy, which is believed to be a main source of the harmful effects of obesity. Here, we recapitulate stress due to jet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a88b6525970d5b522c3835511e80f9
https://doi.org/10.1016/j.celrep.2022.111018
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7
Flattening of diurnal glucocorticoid oscillations causes Cd36 and insulin-mediated obesity
Autor: Stefan Tholen, Kyle M. Kovary, Atefeh Rabiee, Ewa Bielczyk-Maczyńska, Wenting Yang, Fredric B. Kraemer, Mary N. Teruel
Chronic stressors flatten diurnal glucocorticoid oscillations, resulting in obesity, insulin resistance, and diabetes. How such flattened diurnal glucocorticoid oscillations increase fat storage is unknown. Here we investigated the consequences in mi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2db2e7fdc77e45fda257825f85a2e9ef
https://doi.org/10.1101/2020.01.02.893081
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8
Molecular Competition in G1 Controls When Cells Simultaneously Commit to Terminally Differentiate and Exit the Cell Cycle
Autor: Michael L Zhao, Kyle M. Kovary, Atefeh Rabiee, Mary N. Teruel, Zahra Bahrami-Nejad, Brooks Taylor
Publikováno v: Cell reports
Cell Reports, Vol 31, Iss 11, Pp 107769-(2020)
SUMMARY Terminal differentiation is essential for the development and maintenance of tissues in all multi-cellular organisms and is associated with permanent exit from the cell cycle. Failure to permanently exit the cell cycle can result in cancer an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5399af3df451ccb56de2aa3d30aed73
https://pubmed.ncbi.nlm.nih.gov/32553172
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9
Molecular competition in G1 controls when cells simultaneously commit to terminally differentiate and exit the cell-cycle
Autor: Mary N. Teruel, Brooks Taylor, Zahra Bahrami-Nejad, Kyle M. Kovary, Atefeh Rabiee, Michael L Zhao
SUMMARYTerminal differentiation is essential for the development and maintenance of tissues in all multi-cellular organisms and is associated with a permanent exit from the cell cycle. Failure to permanently exit the cell cycle can result in cancer a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5128955a220f753ac033fde8bae483de
https://doi.org/10.1101/632570
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10
Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice[S]
Autor: Wen-Jun Shen, Robert Ahrends, Fredric B. Kraemer, Olivia Wu, Kyle M. Kovary, Brian J. Feldman, Mary N. Teruel, Asuka Ota, Marco Costa
Publikováno v: Journal of Lipid Research
Journal of Lipid Research, Vol 56, Iss 5, Pp 1068-1078 (2015)
Journal of lipid research, vol 56, iss 5
Insulin resistance (IR) underlies metabolic disease. Visceral, but not subcutaneous, white adipose tissue (WAT) has been linked to the development of IR, potentially due to differences in regulatory protein abundance. Here we investigate how protein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3db7dfad24138db736ad5245a1ff433
http://europepmc.org/articles/PMC4409283
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